Potential of Selected Strains of Lactic Acid Bacteria to Induce a Th1 Immune Profile

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概要

• 論文の詳細を見る

• Lactic acid bacteria (LAB) might switch the Th2 biased immune response in allergic patients towards a balanced Th1/Th2 immune profile, leading to amelioration of allergy. To select strains of LAB that could be of potential application for foods in controlling allergy, 35 bacterial strains were screened in vitro using murine splenocytes and peritoneal exudate cells (PECs). Streptococcus thermophilus AHU1838 (FERM AP-21009), and Lactobacillus paracasei subsp. casei AHU1839 (FERM AP-21010) enhanced the secretion of Th1 cytokines such as interferon-γ (IFN-γ) and interleukin-12 (IL-12). The two strains of LAB also up-regulated the expression of CD40, and CD86 in dendritic cells (DCs), and activated cytotoxic T lymphocytes (CTL). These two strains could therefore be used in producing fermented food products that can enhance the Th1 immune profile which is important in ameliorating allergy.

• 社団法人 日本農芸化学会の論文
• 2008-11-23

著者

• NISHIMURA Takashi

  Division of Immunoregulation, Institute for Genetic Medicine, Hokkaido University

• Sone Teruo

  Laboratory of Applied Microbiology, Graduate School of Agriculture, Hokkaido University

• Tanaka Michiko

  Laboratory of Applied Microbiology, Graduate School of Agriculture, Hokkaido University

• Asano Kozo

  Laboratory of Applied Microbiology, Graduate School of Agriculture, Hokkaido University

• Sone Teruo

  Laboratory Of Applied Microbiology Graduate School Of Agriculture Hokkaido University

• Sone Teruo

  北海道大学 農学研究院応用生命科学部門

• Sone Teruo

  Laboratory Of Applied Microbiology Research Group Of Molecular Bioscience Division Of Applied Biosci

• Tanaka Michiko

  Laboratory Of Applied Microbiology Graduate School Of Agriculture Hokkaido University

• Nishimura T

  Division Of Immunoregulation Department Of Radiology Hokkaido University

• 池田 宏信

  鹿児島大学工学部

• Ikeda Hiroaki

  Department Of Medical Oncology Kkr Sapporo Medical Center

• Sone Teruo

  Laboratory Of Applied Microbiology Department Of Bioscience And Chemistry Faculty Of Agriculture Hok

• Ikeda H

  Department Of Science Kyoto University

• 池田 宏信

  高エネルギー研

• Asano Kozo

  Lab. Of Applied Microbiology Graduate School Of Agriculture Hokkaido Univ. Kita-9 Nishi-9 Sapporo 06

• Asano K

  Foods And Liquors Research Laboratories Kyowa Hakko Kogyo Co. Ltd.

• Asano Kozo

  Laboratory Of Applied Microbiology Graduate School Of Agriculture Hokkaido University

• Asano Kozo

  北海道大学農学部応用生命科学専攻

• Asano Kozo

  Division Of Applied Bioscience Graduate School Of Agriculture Hokkaido University

• Tanaka M

  Laboratory Of Applied Microbiology Graduate School Of Agriculture Hokkaido University

• Iguchi Takeshi

  Division Of Immunoregulation Section Of Disease Control Institute For Genetic Medicine Hokkaido Univ

• Ikeda Hironobu

  Fukuoka Agricultural Research Center

• Ikeda Hironobu

  Neutron Science Laboratory Institute Of Materials Structure Science High Energy Accelerator Research

• Nishimura Takashi

  Division Of Immunoregulation Section Of Disease Control Institute For Genetic Medicine And Hokkaido

• Shiomi Takuya

  Fancl Res. Inst. Fancl Corp.

• Ikeda Hiroaki

  Fac. Of Medicine Mie Univ.

• Takebayashi M

  Laboratory Of Applied Microbiology Graduate School Of Agriculture Hokkaido University

• Ongol Martin

  Laboratory of Applied Microbiology, Graduate School of Agriculture, Hokkaido University

• Iguchi Takeshi

  Fujiya Co., Ltd., Fundamental Research Laboratory

• IKEDA Hiroaki

  Faculty of Medicine, Mie University

• Akio Maeda

  Faculty Of Engineering Kagoshima University

• Iguchi Takeshi

  Fujiya Co. Ltd.

• Ikeda Hiroaki

  Faculty Of Medicine Mie University

• Nishimura Takashi

  Division Of Arrhythmia And Electrophysiology Department Of Cardiovascular Medicine National Cerebral

• Ikeda Hiroaki

  Faculty Of Engineering Dept. Of Electric And Electronics Engineering Chiba University

• Nishimura Takashi

  Division Of Immunoregulation Institute For Genetic Medicine Hokkaido University

• Tanaka Michiko

  Division Of Applied Bioscience Graduate School Of Agriculture Hokkaido University

• Tanaka Michiko

  Laboratory Of Applied Microbiology Graduate Faculty Of Agriculture Hokkaido University

• Asano Kozo

  Laboratory Of Applied Microbiology Graduate Faculty Of Agriculture Hokkaido University

• Sone Teruo

  Laboratory of Applied Microbiology, Graduate Faculty of Agriculture, Hokkaido University

• Tanaka Michiko

  Laboratory of Applied Microbiology, Graduate Faculty of Agriculture, Hokkaido University

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