Effects of difructose anhydride III (DFA III) administration on rat intestinal microbiota.

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概要

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• The effects of difructose anhydride III (di-D-fructofuranose-1,2′:2,3′-dianhydride; DFA III) administration (3% DFA III for 4 weeks) on rat intestinal microbiota were examined using denaturing gradient gel electrophoresis (DGGE). According to DGGE profiles, the number of bacteria related to Bacteroides acidofaciens and uncultured bacteria within the Clostridium lituseburense group decreased, while that of bacteria related to Bacteroides vulgatus, Bacteroides uniformis and Ruminococcus productus increased in DFA III-fed rat cecum. In the cecal contents of DFA III-fed rats, a lowering of pH and an increase in short chain fatty acids (SCFAs), especially acetic acid, were observed. The DFA III-assimilating bacterium, Ruminococcus sp. M-1, was isolated from the cecal contents of DFA III-fed rats. The strain had 98% similarity with R. productus ATCC 27340T (L76595), and mainly produced acetic acid. These results confirmed that the bacteria harmful to host health were not increased by DFA III administration. Moreover, DFA III stimulated the growth of Ruminococcus sp. M-1 producing acetic acid, which may alter the intestinal microbiota towards a healthier composition. It is expected that DFA III would be a new candidate as a prebiotic.

• 社団法人日本生物工学会の論文
• 2005-03-25

著者

• Yokota Atsushi

  Laboratory of Microbial Physiology, Research Faculty of Agriculture, Hokkaido University

• Sone Teruo

  Laboratory of Applied Microbiology, Graduate School of Agriculture, Hokkaido University

• Asano Kozo

  Laboratory of Applied Microbiology, Graduate School of Agriculture, Hokkaido University

• Sone Teruo

  Laboratory Of Applied Microbiology Graduate School Of Agriculture Hokkaido University

• Sone Teruo

  Laboratory Of Applied Microbiology Research Group Of Molecular Bioscience Division Of Applied Biosci

• Minamida Kimiko

  Division of Applied Bioscience, Graduate School of Agriculture, Hokkaido University

• Minamida Kimiko

  Northern Advancement Center for Science and Technology

• Sujaya I

  Northern Advancement Center for Science and Technology

• SHIGA KAZUKI

  Northern Advancement Center for Science and Technology

• HARA HIROSHI

  Laboratory of Nutritional Biochemistry, Graduate School of Agriculture, Hokkaido University

• TOMITA FUSAO

  Laboratory of Applied Microbiology, Graduate School of Agriculture, Hokkaido University

• 冨田 房男

  北海道大学農学部

• 冨田 房男

  Hokkaido Study Center The University Of Air

• 横田 篤

  Laboratory Of Microbial Physiology Research Faculty Of Agriculture Hokkaido University

• Sujaya Inengah

  Northern Advancement Center For Science And Technology

• Sone T

  Laboratory Of Applied Microbiology Graduate School Of Agriculture Hokkaido University

• Sone Teruo

  Laboratory Of Applied Microbiology Department Of Bioscience And Chemistry Faculty Of Agriculture Hok

• Yokota Atsushi

  Lab. Of Microbial Physiology Res. Fac. Of Agriculture Hokkaido Univ. Kita 9 Nishi 9 Kita-ku Sapporo

• 横田 篤

  北大 大学院農学研究院

• Sujaya I-nengah

  Department Of Bioscience And Chemistry Graduate School Of Agriculture Hokkaido University

• Yokota Atsushi

  Laboratory Of Bioorganic Chemistry

• Yokota A

  Laboratory Of Applied Microbiology Department Of Bioscience And Chemistry Faculty Of Agriculture Hok

• Yokota Atsushi

  Laboratory Of Microbial Physiology Research Faculty Of Agriculture Hokkaido University

• Yokota Atsushi

  Hokkaido Univ. Sapporo Jpn

• Yokota Atsushi

  Laboratory Of Applied Microbiology Department Of Bioscience And Chemistry Faculty Of Agriculture Hok

• Asano Kozo

  Laboratory Of Applied Microbiology Graduate School Of Agriculture Hokkaido University

• Asano Kozo

  北海道大学農学部応用生命科学専攻

• Tomita Fusao

  Hokkaido University:hokkaido Study Center University Of The Air

• Tomita Fusao

  Laboratory Of Applied Microbiology

• Tomita Fusao

  Department Of Agricultural Chemistry Faculty Of Agriculture Hokkaido University

• Tomita Fusao

  Department Of Agricultural Biochemistry Faculty Of Agriculture Hokkaido University

• Tomita Fusao

  Laboratory Of Applied Microbiology Department Of Bioscience And Chemistry Faculty Of Agriculture Hok

• Shiomi Takuya

  Fancl Res. Inst. Fancl Corp.

• Hara H

  Lab. Of Nutritional Biochemistry Div. Of Applied Bioscience Graduate School Of Agriculture Hokkaido

• Minamida Kimiko

  Division Of Applied Bioscience Graduate School Of Agriculture Hokkaido University

• Yokota Atsushi

  Lab. Microb. Physiol. Grad. Sch. Agric. Hokkaido Univ.

• Hara Hiroshi

  Toxicology Laboratory Chugai Pharmaceutical Co. Ltd.

• Hara Hiroshi

  Laboratory Of Nutritional Biochemistry Division Of Applied Bioscience Graduate School Of Agriculture

• Asano Kozo

  Laboratory Of Applied Microbiology Graduate Faculty Of Agriculture Hokkaido University

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