Pediococcus pentosaceus NB-17 for Probiotic Use(MICROBIAL PHYSIOLOGY AND BIOTECHNOLOGY)
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概要
- 論文の詳細を見る
The plant-derived Pediococcus pentosaceus NB-17 was isolated from Japanese traditional vegetable pickles. The production of cytokines from mouse spleen cells co-cultivated with heat-killed bacteria was investigated in vitro. The bacteria significantly induced secretion levels of interferon (IFN)-γ and interleukin (IL)-12 p70, and suppressed IL-4 productions in ovalbumin (OVA) sensitized mouse spleen cells. Therefore, the bacteria could effectively stimulate immune activities and showed allergic inhibitory effects. Further study on acid tolerance was performed under simulated gastric conditions and NB-17 showed resistance to simulated gastric acidity at pH 3.0 and pH 2.5. Moreover, after oral administration of the intact cells to rats, bacterial colonies derived from feces were analyzed by random amplification polymorphic DNA (RAPD). It was confirmed that the administered strain NB-17 remained alive in feces. These results suggest the possibility to use the P. pentosaceus NB-17 as functional foods.
- 社団法人日本生物工学会の論文
- 2008-07-25
著者
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Yasokawa Daisuke
Hokkaido Food Processing Research Center, Department of Food Biotechnology
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Yasokawa Daisuke
Hokkaido Food Processing Res. Center
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Yasokawa Daisuke
Hokkaido Food Processing Research Center
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ASANO Kozo
Division of Applied Bioscience, Graduate School of Agriculture, Hokkaido University
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Minamida Kimiko
Division of Applied Bioscience, Graduate School of Agriculture, Hokkaido University
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Hara Hiroshi
Division of Applied Bioscience, Graduate School of Agriculture, Hokkaido University
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Wang Qi
日生バイオ
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Asano Kozo
Lab. Of Applied Microbiology Graduate School Of Agriculture Hokkaido Univ. Kita-9 Nishi-9 Sapporo 06
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Asano K
Foods And Liquors Research Laboratories Kyowa Hakko Kogyo Co. Ltd.
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Asano Kozo
北海道大学農学部応用生命科学専攻
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Asano Kozo
Division Of Applied Bioscience Graduate School Of Agriculture Hokkaido University
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Sugi Masahito
Nisseibio Co. Ltd
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Hara H
Lab. Of Nutritional Biochemistry Div. Of Applied Bioscience Graduate School Of Agriculture Hokkaido
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Jonganurakkun Benjamas
Nisseibio Co., Ltd
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Wang Qi
Nisseibio Co., Ltd
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Xu Shan
Nisseibio Co., Ltd
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Tada Yuya
Nisseibio Co., Ltd
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Minamida Kimiko
Division Of Applied Bioscience Graduate School Of Agriculture Hokkaido University
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Jonganurakkun Benjamas
Nisseibio Co. Ltd
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Xu Shan
Nisseibio Co. Ltd
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Tada Yuya
Nisseibio Co. Ltd
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Hara Hiroshi
Toxicology Laboratory Chugai Pharmaceutical Co. Ltd.
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Wang Qi
Nisseibio Co. Ltd
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Hara Hiroshi
Division Of Applied Bioscience Graduate School Of Agriculture Hokkaido University
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