DNA microarray analysis suggests that zinc pyrithione causes iron starvation to the yeast Saccharomyces cerevisiae(ENVIRONMENTAL BIOTECHNOLOGY)
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概要
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Zinc pyrithione has been used in anti-dandruff shampoos and in anti-fouling paint on ships. However, little is known of its mode of action. We characterized the effects of sub-lethal concentrations of zinc pyrithione (Zpt) on Saccharomyces cerevisiae using DNA microarrays. The majority of the strongly upregulated genes are related to iron transport, and many of the strongly downregulated genes are related to the biosynthesis of cytochrome (heme). These data suggest that Zpt induces severe iron starvation. To confirm the DNA microarray data, we supplemented cultures containing Zpt with iron, and the growth of the yeast was restored significantly. From these results, we propose that the principal toxicity of zinc pyrithione arises from iron starvation.
著者
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Iwahashi Yumiko
National Food Research Institute (nfri)
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Iwahashi Yumiko
National Food Research Institute (nfri) National Food Research Institute National Agriculture And Fo
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Yasokawa Daisuke
Hokkaido Food Processing Research Center, Department of Food Biotechnology
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Murata Satomi
Health Technology Research Center (HTRC), National Institute of Advanced Industrial Science and Tech
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Kitagawa Emiko
Health Technology Research Center (HTRC), National Institute of Advanced Industrial Science and Tech
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Kishi Katsuyuki
Japan Pulp and Paper Research Institute, Inc.
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Okumura Yukihiro
Hokkaido Food Processing Research Center, Department of Food Biotechnology
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Iwahashi Hitoshi
Health Technology Research Center (HTRC), National Institute of Advanced Industrial Science and Tech
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Yasokawa Daisuke
Hokkaido Food Processing Res. Center
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Yasokawa Daisuke
Hokkaido Food Processing Research Center Department Of Food Biotechnology
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Murata Satomi
Health Technology Research Center (htrc) National Institute Of Advanced Industrial Science And Techn
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Kitagawa Emiko
Health Technology Research Center (htrc) National Institute Of Advanced Industrial Science And Techn
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Kitagawa Emiko
Health Technol. Res. Center (htrc) National Inst. Of Advanced Industrial Sci. And Technol. (aist) Ts
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Kishi Katsuyuki
Japan Pulp And Paper Research Institute Inc.
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Okumura Yukihiro
Hokkaido Food Processing Research Center Department Of Food Biotechnology
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Iwahashi Hitoshi
Health Technology Research Center (htrc) National Institute Of Advanced Industrial Science And Techn
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Iwahashi Hitoshi
Health Research Institute National Institute Of Advanced Industrial Science And Technology
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Iwahashi Hitoshi
Health Technology Research Center (htrc) National Institute Of Advanced Industrial Science And Technology (aist)
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OKUMURA Yukihiro
Hokkaido Food Processing Research Center
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