Toxicogenomics using yeast DNA microarrays
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概要
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Development of genomics and bioinformatics enable us to analyze the global gene expression profiles of cells by DNA microarray. Changes in gene expression patterns indicate changes in its physiological conditions. Following the exposure of an organism or cell to toxic chemicals or other environmental stresses, the global genetic responses can be expeditiously and easily analyzed. Baker's yeast, Saccharomyces cerevisiae, is one of the most studied and useful model eukaryotes. The biggest advantage of yeast genomics is the available functional information for each gene and a considerable number of data are accumulating in the field of toxicity assessment using yeast DNA microarray. In this review, we discuss the toxicogenomics of metal ions, alcohols and aldehydes, and other chemicals.
著者
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Yasokawa Daisuke
Hokkaido Food Processing Research Center, Department of Food Biotechnology
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Iwahashi Hitoshi
Health Technology Research Center (HTRC), National Institute of Advanced Industrial Science and Tech
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Yasokawa Daisuke
Hokkaido Food Processing Res. Center
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Yasokawa Daisuke
Hokkaido Food Processing Research Center Department Of Food Development
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Iwahashi Hitoshi
Health Technology Research Center (htrc) National Institute Of Advanced Industrial Science And Techn
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Iwahashi Hitoshi
Health Research Institute National Institute Of Advanced Industrial Science And Technology
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