Altered Regulation of Aromatic Amino Acid Biosynthesis in β-Phenylethyl-alcohol-overproducing Mutants of Sake Yeast Saccharomyces cerevisiae(Microbiology & Fermentation Industry)

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概要

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• Mutants resistant to the phenylalanine analogues o-fluoro-DL-phenylalanine (OFF) or p-fluoro-DL-phenylalanine (PFP) were isolated from a sake yeast, Saccharomyces cerevisiae Kyokai No. 9. They produced large amounts of β-phenylethyl alcohol and its acetate ester, which are rose-like flavor components. The tyrosine-dependent isozyme of 3-deoxy-D-arabino-heptulosonate-7-phosphate synthase (DAHP synthase; EC 4.1.2.15), in one of the OFP-resistant mutants was released from feedback inhibition by tyrosine. This mutant overproduced tyrosine in addition to β-phenylethyl alcohol and phenylalanine in minimal medium. In the PFP-resistant mutants, the activity of prephenate dehydrogenase (EC 1.3.1.12) was decreased to 5% of that in the wild type strain, while its DAHP synthase was increased four-fold. The tyrosine-dependent isozyme of this mutant was still sensitive to tyrosine. This mutant also overproduced tryptophan and phenylalanine in addition to β-phenylethyl alcohol in minimal medium.

著者

• Asano Kozo

  北海道大学農学部応用生命科学専攻

• Asano Kozo

  Foods And Liquors Research Laboratories Kyowa Hakko Kogyo Co. Ltd.

• Watanabe M

  Foods And Liquors Research Laboratories Kyowa Hakko Kogyo Co. Ltd.

• Watanabe M

  Graduate School Of Engineering Hiroshima Kokusai Gakuin University

• FUKUDA KAZURO

  Foods and Liquors Research Laboratories, Kyowa Hakko Kogyo Co. Ltd.,

• WATANABE MAKOTO

  Foods and Liquors Research Laboratories, Kyowa Hakko Kogyo Co. Ltd.,

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