Putative Regulatory Gene for Polysaccharide Synthesis of Streptococcus agalactiae Type Ia

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概要

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• The DNA sequence of downstream and upstream regions of capsular polysaccharide biosynthesis (cps) gene cluster of Streptococcus agalactiae type Ia was determined. The overall structure of this region is very similar to a portion of the genome of S. pyogenes, although S. pyogenes does not contain cps genes. In the upstream region, a putative regulatory gene was identified and designated as cpsIaR. From the similarity of the amino acid sequences, the gene product seems to belong to an LysR family of transcriptional regulatory proteins. cpsIaR seems to be transcribed in the direction opposite to cps genes from two different but closely positioned promoters. GST-fused CpsIaR protein binds to the cpsIaA promoter region, suggesting that the protein controls the expression of cpsIa gene cluster

• 社団法人日本生物工学会の論文
• 2002-01-25

著者

• 三宅 克英

  名大院・工・生物機能

• YAMAMOTO Shin

  Department of Thermonuclear Fusion Research, Japan Atomic Energy Research Institute

• WATANABE Masaki

  Department of Biopharmaceutics, Graduate School of Pharmaceutical Sciences, Osaka University

• IIJIMA SHINJI

  Department of Chemical Engineering, Faculty of Engineering, Nagoya University

• Watanabe M

  Foods And Liquors Research Laboratories Kyowa Hakko Kogyo Co. Ltd.

• Iijima Shinji

  Department Of Biotechnology School Of Engineering Naogya University

• Iijima Shinji

  Department Of Biotechnology Faculty Of Engineering Nagoya University

• Sugimoto Yukihiro

  Arid Land Research Center, Tottori Univ.

• MIYAKE Katsuhide

  Research Center for Advanced Waste and Emission Management, Nagoya University

• Yamamoto Shinjiro

  Department Of Bioengineering Tokyo Institute Of Technology:(present Address)department Of Applied Li

• Yamamoto S

  Department Of Biotechnology Graduate School Of Engineering Nagoya University

• Watanabe M

  Graduate School Of Engineering Hiroshima Kokusai Gakuin University

• Koike Y

  Nagoya Univ. Nagoya Jpn

• KATAOKA YOHEI

  Department of Biotechnology Graduate School of Engineering, Nagoya University

• KOIKE YOICHI

  Department of Biotechnology, Graduate School of Engineering, Nagoya University

• Koike Yoichi

  Department Of Biotechnology Graduate School Of Engineering Nagoya University

• Yamamoto S

  Department Of Bioengineering Tokyo Institute Of Technology

• Miyake K

  Nagoya University

• Watanabe Masaki

  Department Of Applied Chemistry Graduate School Of Science And Engineering Ehime University

• Yamamoto Shin

  Department Of Cardiothoracic Surgery Juntendo University School Of Medicine

• IIJIMA Shinji

  Department of Agricultural Chemistry, The University of Tokyo

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