Transport of Human Immunoglobulin G and Fc-Fusion Proteins to Chicken Egg Yolk(BIOCHEMICAL ENGINEERING)

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概要

• 論文の詳細を見る

• We examined the transport of human immunoglobulin G (IgG) subclasses and fusion proteins with the Fc region of human IgG to the egg yolk, after the proteins were injected into a vein of hens. Human IgGs were efficiently transported and accumulated into the yolk, whereas the proteins were not detected in the egg white. Among human IgG subclasses, IgG2 was transported most efficiently. Fc-fusion proteins injected were also transported into the yolk. A fusion protein with the Fc region derived from human IgG2 was more efficiently transported into the yolk than the counterpart fusion with the Fc region from human IgG1. This study shows that the recovery of recombinant antibodies and Fc-fusion proteins from the yolk is an effective method in transgenie chicken bioreactors.

• 社団法人日本生物工学会の論文
• 2006-12-25

著者

• Kawabe Yoshinori

  Department of Chemical Engineering, Faculty of Engineering, Kyushu University

• Kamihira M

  Department Of Biotechnology School Of Engineering Nagoya University

• Kamihira Masamichi

  Nagoya University:(present Office)kyushu University

• Kamihira Masamichi

  名古屋大学 工学研究科生物機能工学

• Kamihira Masamichi

  Department Of Biotechnology Graduate School Of Engineering Nagoya University

• Kawabe Yoshinori

  Department Of Chemical Engineering Faculty Of Engineering Kyushu University

• Kawabe Yoshinori

  Nagoya University:(present Office)kyushu University

• Kawabe Yoshinori

  九州大学 工学研究院化学工学

• Kawabe Yoshinori

  名古屋大学 工学研究科生物機能工学

• Kamihira Masamichi

  Department Of Chemical Engineering Faculty Of Engineering Nagoya University

• Matsumoto Hiroyuki

  Tokyo Institute Of Technology

• Matsumoto Hiroyuki

  Department of Electrical Engineering, Toyo University

• IIJIMA SHINJI

  Department of Chemical Engineering, Faculty of Engineering, Nagoya University

• Iijima S

  Department Of Biotechnology Graduate School Of Engineering Nagoya University

• Iijima Shinji

  Department Of Biotechnology School Of Engineering Naogya University

• Iijima Shinji

  Department Of Biotechnology Faculty Of Engineering Nagoya University

• Iijima S

  Department Of Biotechnology Faculty Of Engineering Nagoya University

• Iijima Shinji

  Department Of Chemical Engineering Nagoya University

• Ando-noumi Naoko

  Department Of Biotechnology Graduate School Of Engineering Nagoya University

• Nishijima Ken-ichi

  Department of Biotechnology, Graduate School of Engineering, Nagoya University

• Ono Ken-ichiro

  Department Of Biotechnology Graduate School Of Engineering Nagoya University

• Nishijima Ken-ichi

  Nagoya University

• Naka Tsutomu

  Department of Biotechnology, Graduate School of Engineering, Nagoya University

• Naka Tsutomu

  Department Of Biotechnology Graduate School Of Engineering Nagoya University

• Kuga Yuko

  Department Of Biotechnology Graduate School Of Engineering Nagoya University

• Matsumoto H

  Tokyo Institute Of Technology Department Of Mechanical Engineering And Science

• Yoshida Kazuhiro

  Department Of Biotechnology Graduate School Of Engineering Nagoya University

• Nishijima Ken-ichi

  Department Of Biotechnology Graduate School Of Engineering Nagoya University

• Nishijima Ken-ichi

  Department Of Applied Biological Chemistry The University Of Tokyo:(present Address)department Of Bl

• Matsumoto Hiroyuki

  Department Of Biochemistry And Molecular Biology University Of Oklahoma Health Sciences Center

• Kawabe Yoshinori

  Department Of Biotechnology Graduate School Of Engineering Nagoya University

• Matsumoto Hiroyuki

  Department Of Biochemistry And Molecular Biology The University Of Oklahoma Health Sciences Center

• Iijima Shinji

  Department of Biotechnology, Graduate School of Engineering, Nagoya University

• Nishijima Kenichi

  Department of Biotechnology, Graduate School of Engineering, Nagoya University

• IIJIMA Shinji

  Department of Agricultural Chemistry, The University of Tokyo

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