Simple Assay Method for Endocrine Disrupters by in Vitro Quail Embryo Culture : Nonylphenol Acts as a Weak Estrogen in Quail Embryos(BIOCHEMICAL ENGINEERING)

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概要

• 論文の詳細を見る

• Many chemicals that are not structurally related to estrogen have estrogen-like activity. In this study, we tried to apply a quail embryo culture system for assessing the in vivo effects of such chemicals on the development of quail embryos. β-Estradiol induced feminization of the gonads of genetically male embryos, which was confirmed by the increase in the size of the left gonad and female-specific aromatase expression, while male-specific SOX9 expression was not affected. Nonylphenol, which has a weak estrogenic activity, reduced the viability and body weight of embryos. Simultaneously, several genetically male embryos were feminized in terms of gonadal size and aromatase expression. These results indicate that the avian embryo culture system was useful for evaluating endocrine disrupters.

• 社団法人日本生物工学会の論文
• 2003-06-25

著者

• Kamihira M

  Department Of Biotechnology School Of Engineering Nagoya University

• Kamihira Masamichi

  Nagoya University:(present Office)kyushu University

• Kamihira Masamichi

  名古屋大学 工学研究科生物機能工学

• Kamihira Masamichi

  Department Of Biotechnology Graduate School Of Engineering Nagoya University

• Kamihira Masamichi

  Department Of Chemical Engineering Faculty Of Engineering Nagoya University

• IIJIMA SHINJI

  Department of Chemical Engineering, Faculty of Engineering, Nagoya University

• Iijima S

  Department Of Biotechnology Graduate School Of Engineering Nagoya University

• Iijima Shinji

  Department Of Biotechnology School Of Engineering Naogya University

• Iijima Shinji

  Department Of Biotechnology Faculty Of Engineering Nagoya University

• Iijima S

  Department Of Biotechnology Faculty Of Engineering Nagoya University

• Iijima Shinji

  Department Of Chemical Engineering Nagoya University

• Nishijima Ken-ichi

  Department of Biotechnology, Graduate School of Engineering, Nagoya University

• Ono Ken-ichiro

  Department Of Biotechnology Graduate School Of Engineering Nagoya University

• Nishijima Ken-ichi

  Nagoya University

• MIYAKE Katsuhide

  Research Center for Advanced Waste and Emission Management, Nagoya University

• ESAKA KAZUHISA

  Department of Biotechnology, Graduate School of Engineering, Nagoya University

• IBUKI HISAYO

  Department of Biotechnology, Graduate School of Engineering, Nagoya University

• Ibuki Hisayo

  Department Of Biotechnology Graduate School Of Engineering Nagoya University

• Esaka Kazuhisa

  Department Of Biotechnology Graduate School Of Engineering Nagoya University

• MIYAKE Katsuhide

  Ecotopia Science Institute, Nagoya University

• Nishijima Ken-ichi

  Department Of Biotechnology Graduate School Of Engineering Nagoya University

• Miyake K

  Nagoya University

• Nishijima Ken-ichi

  Department Of Applied Biological Chemistry The University Of Tokyo:(present Address)department Of Bl

• Miyake Katsuhide

  Ecotopia Science Institute Nagoya University

• Nishijima Kenichi

  Department Of Molecular Imaging Graduate School Of Medicine Hokkaido University

• Nishijima Kenichi

  Department of Biotechnology, Graduate School of Engineering, Nagoya University

• IIJIMA Shinji

  Department of Agricultural Chemistry, The University of Tokyo

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