Adaptive On-Line Optimizing Control for Lactic Acid Fermentation

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概要

• 論文の詳細を見る

• The adaptive on-line optimization strategy was applied for continous lactic acid fermentation. The control objective was to maximize the lactate production rate while keeping the lactate concentration at a specified value. The control task was divided into two. The task of the upper layer in the hierarchical control scheme was to search for the optimal operating poing for cell concentration, while the task of the lower layer was to make the cell and lactate concentration follow the respective set points which were either specified or given from the upper layer. The cell and lactate concentrations were either measured on-line or estimated every 2 min. The bioreactor was equipped with a hollow-fiber module, and control was implemented by manipulating the draw-off rate through the filter and the bleed stream flow rate in an on-off manner. It was experimentally shown that productivity as high as 20kg/m^3・h could be attained and maintained for about 40-50h when the lactate concentration was kept at either 20kg/m^3 or 30kg/m^3.

• 社団法人日本生物工学会の論文
• 1990-12-25

著者

• KOBAYASHI Takeshi

  Department of Electrical Engineering, Faculty of Engineering Science, Osaka University

• 清水 和幸

  Bes Kyushu Inst. Technol.

• Shimizu Kazuyuki

  Department Of Biochemical Engineering & Science Kyushu Institute Of Technology

• Shimizu K

  Department Of Biotechnology Faculty Of Engineering Nagoya University

• IIJIMA SHINJI

  Department of Chemical Engineering, Faculty of Engineering, Nagoya University

• Iijima Shinji

  Department Of Biotechnology School Of Engineering Naogya University

• Iijima Shinji

  Department Of Biotechnology Faculty Of Engineering Nagoya University

• Iijima S

  Department Of Biotechnology Faculty Of Engineering Nagoya University

• SHI ZHONGPING

  Department of Biotechnology, Faculty of Engineering, Nagoya University

• MORISUE TOSHIYA

  Department of Chemical Engineering, Nagoya University

• Kobayashi Takeshi

  Department Of Biological Chemistry College Of Bioscience And Biotechnology Chubu University

• Kobayashi T

  Dep. Of Biological Mechanisms And Functions Graduate School Of Bioagricultural Sciences Nagoya Univ.

• Shi Zhongping

  Department Of Biotechnology Faculty Of Engineering Nagoya University

• Shi Zhongping

  Department Of Biochemical Engineering And Science Kyushu Institute Of Technology

• Kobayashi T

  Univ. Tsukuba Ibaraki Jpn

• Shimizu Kazuyuki

  Department Of Biochem.engineering And Science Kyushu Institute Of Technology

• Morisue T

  Nagoya Univ. Nagoya Jpn

• Morisue Toshiya

  Department Of Chemical Engineering Nagoya University

• Kobayashi Takeshi

  Department Of Biotechnology Graduate School Of Engineering Nagoya University

• KOBAYASHI TAKESHI

  Department of Biotechnology, Faculty of Engineering, Nagoya University

• IIJIMA Shinji

  Department of Agricultural Chemistry, The University of Tokyo

• Shimizu Kazuyuki

  Department of Applied Chemistry for Resources, Tokyo University of Agriculture and Technology

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