A Preprocessing Method for Inferring Genetic Interaction from Gene Expression Data Using Boolean Algorithm(BIOINFORMATICS)
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概要
- 論文の詳細を見る
Unknown genetic regulation mechanisms are expected to be discovered by information technology using large amount of biological data especially for gene expression data. In this study, we propose a novel inferring method for genetic interactions that combines our original preprocessing method and the Boolean algorithm. First, the performance of our method was evaluated using artificial data. The results showed that our method was able to infer genetic interactions with high specificity (specificity=0.629). Then, using our method, the genetic interaction was inferred from the experimental time course data collected using microarray on 69 genes of cell cycle for Saccharomyces cerevisiae. Our method estimated about 80% of all genetic interactions in Kyoto Encyclopedia Genes and Genomes (KEGG) for these genes. Furthermore, our method was able to infer several other genetic interactions that are not included in KEGG but whose existence is supported by other biological reports.
- 社団法人日本生物工学会の論文
- 2004-12-25
著者
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Honda Hiroyuki
Department of Biotechnology, School of Engineering, Nagoya University
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本多 裕之
名大院工・生物機能
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Kobayashi T
School Of Bioscience And Biotechnology Chubu University
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花井 泰三
Department Of Biotechnology School Of Engineering Nagoya University
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KOBAYASHI Takeshi
Department of Electrical Engineering, Faculty of Engineering Science, Osaka University
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Kobayasi T
School Of Bioscience And Biotechnology Chubu University
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Honda Hiroyuki
Department Of Bioengineering Tokyo Institute Of Technology
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HAKAMADA KAZUMI
Department of Biotechnology, School of Engineering, Nagoya University
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Hakamada Kazumi
Department Of Bioengineering School Of Engineering The University Of Tokyo:research Institute For Ce
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Hakamada Kazumi
Department Of Biotechnology School Of Engineering Nagoya University:(present Address)laboratory For
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Kobayashi T
Graduate School Of Marine Science And Technology Tokyo University Of Marine Science And Technology
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Hanai Taizo
Laboratory For Bioinformatics Graduate School Of Systems Life Sciences Kyushu University
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Hanai Taizo
Laboratory For Bioinformatics Graduate School Of System Life Sciences Kyushu University
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Kobayashi Takeshi
Department Of Biological Chemistry College Of Bioscience And Biotechnology Chubu University
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Kobayashi T
Dep. Of Biological Mechanisms And Functions Graduate School Of Bioagricultural Sciences Nagoya Univ.
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Kobayashi T
Graduate School Of Engineering Science Osaka University
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Honda Hiroyuki
Department Of Anesthesia Niigata City General Hospital
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