Medical Application of Functionalized Magnetic Nanoparticles(<Special Issue>Advances in Biomedical Science and Engineering)

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概要

• 論文の詳細を見る

• Since magnetic particles have unique features, the development of a variety of medical applications has been possible. The most unique feature of magnetic particles is their reaction to a magnetic force, and this feature has been utilized in applications such as drug targeting and bioseparation including cell sorting. Recently, magnetic nanoparticles have attracted attention because of their potential as contrast agents for magnetic resonance imaging (MRI) and heating mediators for cancer therapy (hyperthermia). Magnetite cationic liposomes (MCLs), one of the groups of cationic magnetic particles, can be used as carriers to introduce magnetite nanoparticles into target cells since their positively charged surface interacts with the negatively charged cell surface; furthermore, they find applications to hyperthermic treatments. Magnetite nanoparticles conjugated with antibodies (antibody-conjugated magnetoliposomes, AMLs) are also applied to hyperthermia and have enabled tumor-specific contrast enhancement in MRI via systemic administration. Since magnetic nanoparticles are attracted to a high magnetic flux density, it is possible to manipulate cells labeled with magnetic nanoparticles using magnets; this feature has been applied in tissue engineering. Magnetic force and MCLs were used to construct multilayered cell structures and a heterotypic layered 3D coculture system. Thus, the applications of these functionalized magnetic nanoparticles with their unique features will further improve medical techniques.

• 社団法人日本生物工学会の論文
• 2005-07-25

著者

• ITO Akira

  Department of Physics, The Cancer Institute, Japanese Foundation for Cancer Research

• Honda Hiroyuki

  Department of Biotechnology, School of Engineering, Nagoya University

• 本多 裕之

  名大院・工・生物機能

• 本多 裕之

  名大院工・生物機能

• Kobayashi T

  School Of Bioscience And Biotechnology Chubu University

• Kobayasi T

  School Of Bioscience And Biotechnology Chubu University

• SHINKAI Masashige

  Department of Biotechnology, Graduate School of Engineering, Nagoya university

• Ito A

  The Department Of Computer Science And Systems Engineering Faculty Of Engineering Yamaguchi Universi

• Ito Akira

  Dep. Of Chemical Engineering Fac. Of Engineering Kyushu Univ. 744 Motooka Nishi-ku Fukuoka 819-0395

• Honda Hiroyuki

  Department Of Bioengineering Tokyo Institute Of Technology

• Honda Hiroyuki

  Department Of Biotechnology Graduate School Of Engineering Nagoya University

• Kobayashi Takeshi

  School of Bioscience and Biotechnology, Chubu University

• Kobayashi T

  Graduate School Of Marine Science And Technology Tokyo University Of Marine Science And Technology

• Ito Akira

  Dep. Of Biochemistry And Molecular Biology Tokyo Univ. Of Pharmacy And Life Sciences School Of Pharm

• Ito Akira

  Department Of Chemical Engineering Faculty Of Engineering Kyushu University

• Ito A

  Kyorin Pharmaceutical Co. Ltd.

• Ito Akira

  Department Of Biochemistry And Molecular Biology School Of Pharmacy Tokyo University Of Pharmacy And

• Ito Akira

  Graduate School Of Engineering Kyushu University

• Ito Akira

  1st Laboratory Of Soil And Fertilizer Environment Division Chugoku National Agricultural Experiment

• Kobayashi T

  Dep. Of Biological Mechanisms And Functions Graduate School Of Bioagricultural Sciences Nagoya Univ.

• Kobayashi T

  Graduate School Of Engineering Science Osaka University

• Shinkai Masashige

  Dep. Of Chemistry And Biotechnology School Of Engineering Univ. Of Tokyo Tokyo 113-8656 Jpn

• Honda Hiroyuki

  Department Of Anesthesia Niigata City General Hospital

• Ito Akira

  Department Of Chemical Engineering Faculty Of Engineering Kyusyu University

• Kobayashi Takeshi

  School Of Bioscience And Biotechnology Chubu University

• Ito Akira

  Department of Chemical Engineering, Faculty of Engineering, Kyusyu University

• Shinkai Masashige

  Department of Biotechnology, Faculty of Engineering, Nagoya University

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