An Antiprogesterone, Onapristone, Enhances the Gene Expression of Promatrix Metatloproteinase 3/Prostromelysin-1 in the Uterine Cervix of Pregnant Rabbit

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概要

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• Using a progesterone receptor antagonist, onapristone/ZK 98.299, we examined the in-vivo effects of progesterone on the function of uterine cervix during pregnancy. Onapristone was intravenously administered to pregnant rabbits on day 20 post coitum. After 24 h, the antiprogesterone increased the wet weight of the uterine cervix and decreased the DNA concentration in the cervix. In-situ hybridization also indicated that antiprogesterone augmented the expression of matrix metalloproteinase (MMP)-3/stromelysin-1 mRNA in the uterine cervix. These changes are very similar to those observed and reported thus far in ripened and dilated uterine cervix. These results suggest that during pregnancy, progesterone closely participates in the maintenance of the function of uterine cervix by preventing the production of MMPs and thereby destruction of extracellular matrix, and thus add support to the theory that antiprogesterone has the potential to accelerate for the uterine cervical ripening and dilatation.

• 社団法人日本薬学会の論文
• 2002-09-01

著者

• ITO Akira

  Department of Physics, The Cancer Institute, Japanese Foundation for Cancer Research

• SATO Takashi

  Department of Neurosurgery, University of Yamanashi, Faculty of Medicine

• HASHIZUME Kazuyoshi

  Laboratory of Reproductive Endocrinology, National Institute Animal Industry

• Sato Takashi

  Dep. Of Biochemistry And Molecular Biology Tokyo Univ. Of Pharmacy And Life Sciences School Of Pharm

• 橋爪 一善

  農林水産省畜産試験場

• 橋爪 一善

  農業生物資源研究所 発生分化研究グループ 生殖再生研究チーム

• Ito A

  The Department Of Computer Science And Systems Engineering Faculty Of Engineering Yamaguchi Universi

• Ito Akira

  Dep. Of Chemical Engineering Fac. Of Engineering Kyushu Univ. 744 Motooka Nishi-ku Fukuoka 819-0395

• IMADA Keisuke

  Department of Biochemistry and Molecular Biology, School of Pharmacy, Tokyo University of Pharmacy a

• TANIMOTO Akihide

  Second Department of Pathology University of Occupational and Environmental Health, School of Medici

• SASAGURI Yasuyuki

  Second Department of Pathology University of Occupational and Environmental Health, School of Medici

• Sasaguri Y

  Univ. Occupational And Environmental Health Kitakyushu Jpn

• Sasaguri Yasuyuki

  The Second Department Of Pathology School Of Health Science University Of Occupational And Environme

• Hashizume K

  Laboratory Of Reproductive Biology And Technology National Institute Of Agrobiological Sciences

• Hashizume Kazuyoshi

  Laboratory Of Animal Reproduction Faculty Of Agriculture Tohoku University

• Ito Akira

  Dep. Of Biochemistry And Molecular Biology Tokyo Univ. Of Pharmacy And Life Sciences School Of Pharm

• Ito A

  Kyorin Pharmaceutical Co. Ltd.

• Ito Akira

  Department Of Biochemistry And Molecular Biology School Of Pharmacy Tokyo University Of Pharmacy And

• Ito Akira

  Department Of Biochemistry School Of Pharmacy Tokyo University Of Pharmacy And Life Science

• Tanimoto Akihide

  Second Department Of Pathology University Of Occupational And Environmental Health Japan School Of M

• Sasaguri Yasuyuki

  Second Department Of Pathology University Of Occupational And Environmental Health School Of Medicin

• Sato Takashi

  Department Of Internal Medicine And Clinical Immunology Yokohama City University School Of Medicine

• Hashizume Kazuyoshi

  Reproductive Biology And Technology Laboratory Developmental Biology Department National Institute O

• Sato Takashi

  Department Of Communications And Computer Engineering Kyoto University

• Sato Takashi

  Department Of Applied Biochemistry And Food Science Saga University

• Imada Keisuke

  Department of Biochemistry and Molecular Biology, School of Pharmacy, Tokyo University of Pharmacy and Life Science

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