Effects of H_2-Receptor Antagonists on Matrix Metalloproteinases in Rat Gastric Tissues with Acetic Acid-Induced Ulcer
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概要
- 論文の詳細を見る
To investigate the destructive process of connective tissues in gastric ulcer, both collagenolytic and gelatinolytic activities were examined in the homogenates of rat acetic acid-induced gastric ulcer, a typical model of chronic ulcer. Gelatinolytic activity in the ulcerous lesion was significantly higher than that in the normal tissue. However, collagenase was not detected in both normal and ulcerated tissues either by the enzyme assay or by the immunoblotting. By gelatin-gel-zymographic analyses, the gelatinolytic activity was found to be composed of a number of species, mainly 60-, 72-and 92-kDa, all of which were inhibited by ethylenediaminetetraacetic acid. Among the induced matrix metalloproteinases, one crossreacted with a sheep anti-(rabbit prostromelysin) antibody. Thus, in chronic gastric ulcer, it is likely that several metalloproteinases participate in degradation of connective tissue matrices including components of basement membranes. The elevated levels of gelatinolytic activities in the ulcerous tissues and ulcer index were significantly suppressed by treating the animals with famotidine or a new H_2-receptor antagonist, 3-amino-4-[4-[4-(1-piperidinomethyl)-2-pyridyloxy]-cis-2-butenylamino]-3-cyclobutene-1,2-dione hydrochloride (IT-066).
- 公益社団法人日本薬学会の論文
著者
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ITO Akira
Department of Physics, The Cancer Institute, Japanese Foundation for Cancer Research
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Nagase Hideaki
Department Of Biochemistry And Molecular Biology University Of Kansas Medical Center
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Ito Akira
Dep. Of Biochemistry And Molecular Biology Tokyo Univ. Of Pharmacy And Life Sciences School Of Pharm
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Ito Akira
Department Of Biochemistry And Molecular Biology School Of Pharmacy Tokyo University Of Pharmacy And
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MORI YO
Department of Biochemistry, Tokyo College of Pharmacy
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Mori Y
Department Of Biochemistry Tokyo College Of Pharmacy
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Mori Yo
Department Of Biochemistry Tokyo College Of Pharmacy
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KAKIZAKI Mikiko
Department of Biochemistry, Tokyo College of Pharmacy
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MURAKAMI Sigeru
Department of Biochemistry, Tokyo College of Pharmacy
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YAMADA Hisaharu
Department of Biochemistry, Tokyo College of Pharmacy
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Kakizaki Mikiko
Department Of Biochemistry Tokyo College Of Pharmacy:department Of Biochemistry And Molecular Biolog
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Murakami Sigeru
Department Of Biochemistry Tokyo College Of Pharmacy:department Of Biochemistry And Molecular Biolog
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Yamada Hisaharu
Department Of Biochemistry Tokyo College Of Pharmacy:department Of Biochemistry And Molecular Biolog
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