Identification of HLA-A24-Restricted Epitopes with High Affinities to Hsp70 Using Peptide Arrays(METHODS)
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概要
- 論文の詳細を見る
Heat shock protein 70(Hsp70) family members are known as facilitators of immune responses by interacting with receptors on antigen-presenting cells leading to Hsp70-peptide uptake and antigen cross priming. Here, identification of human leukocyte antigen (HLA)-A24-restricted epitopes was achieved using peptide arrays for evaluation of their affinities to Hsp70 and HLA-A24 binding prediction tools. Using Hsp70 as the model antigen, the GYPVTNAVI and VFQHGKVEI peptides were identified as antigens. These peptides actually bound to HLA-A24 in the stabilization assay using T2-A^*2402 cells, and induced a strong peptide-reactive cytotoxic T lymphocyte response in HLA-A24 transgenic mice after vaccination.
- 社団法人日本生物工学会の論文
- 2008-03-25
著者
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ITO Akira
Department of Physics, The Cancer Institute, Japanese Foundation for Cancer Research
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Honda Hiroyuki
Department of Biotechnology, School of Engineering, Nagoya University
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本多 裕之
名大院・工・生物機能
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Okochi Mina
Department of Biotechnology, School of Engineering, Nagoya University
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Kato Ryuji
Department of Biotechnology, School of Engineering, Nagoya University
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本多 裕之
名大院工・生物機能
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Kato Ryuji
Department Of Biotechnology Graduate School Of Engineering Nagoya University
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本多 裕之
Department Of Biotechnology Graduate School Of Engineering Nagoya University:mext Innovative Researc
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Kato Ryuji
Department Of Biotechnology School Of Engineering Nagoya University
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本多 裕之
Department Of Biotechnology School Of Engineering Nagoya University
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Hayashi Hiroki
Department Of Geriatric Medicine And Nephrology Osaka University Graduate School Of Medicine
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SATO Noriyuki
Department of Pathology (Section 1), Sapporo Medical University School of Medicine
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TAMURA Yasuaki
Department of Pathology, Sapporo Medical University School of Medicine
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Sato Noriyuki
Department Of Orthopedic Surgery Sapporo Medical University School Of Medicine
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Ito A
The Department Of Computer Science And Systems Engineering Faculty Of Engineering Yamaguchi Universi
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Honda Hiroyuki
Department Of Bioengineering Tokyo Institute Of Technology
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Honda Hiroyuki
Department Of Biotechnology Graduate School Of Engineering Nagoya University
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Tamura Yasuaki
Department Of Pathology School Of Medicine Sapporo Medical University
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Tomita Yasuyuki
名古屋大学 工学部生物機能工学分野
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Sato Noriyuki
Department Of Pathology Sapporo Medical University
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Tomita Yasuyuki
Department Of Pathology School Of Medicine Sapporo Medical University
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Tamura Yasuaki
Department Of Gastroenterology Sapporo Medical University
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Okochi Mina
Department Of Biotechnology School Of Engineering Nagoya University
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Hosokawa Hiroyuki
Department Of Biotechnology Graduate School Of Engineering Nagoya University:mext Innovative Researc
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Ito Akira
Dep. Of Biochemistry And Molecular Biology Tokyo Univ. Of Pharmacy And Life Sciences School Of Pharm
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Ito A
Kyorin Pharmaceutical Co. Ltd.
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Ito Akira
Department Of Biochemistry And Molecular Biology School Of Pharmacy Tokyo University Of Pharmacy And
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Ito Akira
1st Laboratory Of Soil And Fertilizer Environment Division Chugoku National Agricultural Experiment
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Honda Hiroyuki
Graduate School Of Engineering Nagoya University
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Honda Hiroyuki
Department Of Chemical Engineering Faculty Of Engineering Nagoya University
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Kato Ryuji
名古屋大学 工学研究科バイオテクノロジー講座
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Okochi Mina
Department Of Biotechnology Nagoya University
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Hamada Hirobumi
Department Of Biotechnology School Of Engineering Nagoya University
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Honda Hiroyuki
Department Of Anesthesia Niigata City General Hospital
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Ito Akira
Department Of Chemical Engineering Faculty Of Engineering Kyusyu University
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Hayashi Hiroki
Department Of Biomolecular Engineering Graduate School Of Engineering Tohoku University
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Sato Noriyuki
Department Of Biological Chemistry Faculty Of Agriculture Yamaguchi University
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Okochi Mina
Department Of Biotechnology Graduate School Of Engineering Nagoya University
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Ito Akira
Department of Chemical Engineering, Faculty of Engineering, Kyusyu University
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