Classification Method for Predicting the Development of Myocardial Infarction by Using the Interaction between Genetic and Environmental Factors

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概要

• 論文の詳細を見る

• Multifactorial diseases, such as lifestyle-related diseases, for example, cancer, diabetes mellitus, and myocardial infarction, are believed to be caused by the complex interactions between various environmental factors on a polygenic basis. In addition, it is believed that genetic risk factors for the same disease differ on an individual basis according to their susceptible environmental factors. In the present study, to predict the development of myocardial infarction (MI) and classify the subjects into personally optimum development patterns, we have extracted risk factor candidates (RFCs) that comprised a state that is a derivative form of polymorphisms and environmental factors using a statistical test. We then selected the risk factors using a criterion for detecting personal group (CDPG), which is defined in the present study. By using CDPG, we could predict the development of MI in blinded subjects with an accuracy greater than 75%. In addition, the risk percentage for MI was higher with an increase in the number of selected risk factors in the blinded data. Since sensitivity using the CDPG was high, it can be an effective and useful tool in preventive medicine and its use may provide a high quality of life and reduce medical costs.

• 一般社団法人情報処理学会の論文
• 2006-11-15

著者

• Honda Hiroyuki

  Department of Biotechnology, School of Engineering, Nagoya University

• Abe Hiroshi

  Department Of Cardiology National Cardiovascular Center

• Yokota M

  Department Of Genome Science School Of Dentistry Aichi-gakuin University

• Asano Hiroyuki

  Department of Cardiology, Nagoya University Graduate School of Medicine

• Tomita Yasuyuki

  Department of Biotechnology, School of Engineering, Nagoya University

• Abe Hiroshi

  Cardiovascular Division Osaka Minami Medical Center

• Yokota Mitsuhiro

  Department Of Genome Science School Of Dentistry Aichi-gakuin University

• Yokota Mitsuhiro

  Department Of Clinical Pathophysiology Nagoya University Graduate School Of Medicine

• Izawa Hideo

  Division Of Cardiology Fujita Health University Hospital

• Izawa Hideo

  Department Of Cardiology Nagoya University Graduate School Of Medicine

• Asanuma Hiroshi

  Departments Of Cardiology Chubu Rosai Hospital

• Asano Hiroyuki

  Departments Of Cardiology Chubu Rosai Hospital

• Asano Hiroyuki

  Department Of Cardiology Nagoya University Graduate School Of Medicine

• Honda Hiroyuki

  Department Of Bioengineering Tokyo Institute Of Technology

• Hirashiki Akihiro

  Nagoya University Graduate School Of Medicine

• Tamura Yasuaki

  Department Of Pathology School Of Medicine Sapporo Medical University

• Tomita Yasuyuki

  名古屋大学 工学部生物機能工学分野

• Tomita Yasuyuki

  Department Of Biotechnology School Of Engineering Nagoya University

• Kobayashi Takeshi

  School of Bioscience and Biotechnology, Chubu University

• Izawa Hideo

  Department Of Cardiology

• Ando Hirohiko

  Departments Of Cardiology Chubu Rosai Hospital

• Tomita Yasuyuki

  Department Of Pathology School Of Medicine Sapporo Medical University

• Okada Mitsuhiro

  Department Of Genome Science School Of Dentistry Aichi-gakuin University

• Yokota Mitsuhiro

  Division Of Cardiology Gifu Social-insurance Hospital

• Abe H

  Institute Of Symbiotic Science And Technology Tokyo University Of Agriculture And Technology

• Yokota Mitsuhiro

  Department Clinical Laboratory Nagoya University Hospital

• Izawa Hideo

  Department Of Cardiovascular Medicine Nagoya University Graduate School Of Medicine

• Yokota Mitsuhiro

  Graduate School Of Medicine Nagoya University

• Yokota Mitsuhiro

  Nagoya University College Of Medical Technology Cardiovascular Section Department Of Clinical Labora

• Honda Hiroyuki

  Department Of Anesthesia Niigata City General Hospital

• Kobayashi Takeshi

  School Of Bioscience And Biotechnology Chubu University

• Asano Hiroyuki

  Department Of Cardiology Chiousha Iwakura Hospital

• Asano Hiroyuki

  Department of Advanced Medicine in Cardiopulmonary Disease, Nagoya University Graduate School of Medicine

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