Screening of Epithelial Cell-Adhesive Peptides from Fibronectin Loop Region and Its Cell Specificity

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概要

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• Using a peptide array-based cell system, screening of cell adhesive peptides has been investigated against two epithelial-type cells, such as mouse lung epithelial cell (mLEC) and mouse glomerular epithelial cell (mGEC), and one endothelial cell such as human umbilical vein endothelial cell (HUVEC). When 63 pentamer peptide sequences of human fibronectin type III domain were synthesized on the cellulose membrane assayed, GSKST (No. 124) and GLKPG (No. 126) showed high adhesion activity against all three type cells. The adhesion pattern of mGEC using the library was different from mLEC. Eight adhesive peptides were found for mGEC as peptides with higher adhesion activity compared with HUVEC. It was found that the adhesion pattern of mLEC was similar to that of human mesenchymal stem cell (MSC), not HUVEC. The results suggest that a tissue specific adhesion peptides can be designed, which has the potential for the development of a tissue specific molecular tag.

• 社団法人 化学工学会の論文
• 2009-07-01

著者

• 永井 敦

  日本大学

• Honda Hiroyuki

  Department of Biotechnology, School of Engineering, Nagoya University

• 本多 裕之

  名大院・工・生物機能

• Okochi Mina

  Department of Biotechnology, School of Engineering, Nagoya University

• 本多 裕之

  名大院工・生物機能

• Suzuki K

  Department Of Urology Gunma University Graduate School Of Medicine

• 本多 裕之

  Department Of Biotechnology Graduate School Of Engineering Nagoya University:mext Innovative Researc

• 本多 裕之

  Department Of Biotechnology School Of Engineering Nagoya University

• KAGA Chiaki

  Department of Biotechnology, School of Engineering, Nagoya University

• NOMURA Shigeyuki

  Department of Biotechnology, School of Engineering, Nagoya University

• NOZU Tomoko

  National Institute of Infectious Diseases

• NAGAO Tomokazu

  National Institute of Infectious Diseases

• NAGAI Atsushi

  Department of Internal Medicine-1, Tokyo Women's Medical University

• NAKAYAMA Toshinori

  Department of Immunology, Graduate School of Medicine, Chiba University

• SUZUKI Kazuo

  National Institute of Infectious Diseases

• Nagai Atsushi

  Liberal Arts And Basic Sciences College Of Industrial Technology Nihon University

• Suzuki Keita

  Environmental Health Sciences Tohoku University Graduate School Of Medicine

• Suzuki Maki

  東北大学 医系研究 障害科学 専攻 高次機能障害学 分野

• Nagai Atsushi

  Department Of Legal Medicine Gifu University School Of Medicine

• Honda Hiroyuki

  Department Of Bioengineering Tokyo Institute Of Technology

• Honda Hiroyuki

  Department Of Biotechnology Graduate School Of Engineering Nagoya University

• Nakayama T

  Department Of Immunology Graduate School Of Medicine Chiba University

• Nakayama Toshinori

  Department Of Immunology Graduate School Of Medicine Chiba University

• Nakayama Toshinori

  Department Of Molecular Immunology Graduate School Of Medicine Chiba University

• Nakayama Toshinori

  Crest (core Research For Evolutional Science And Technology) Project And Department Of Molecular Imm

• Nakayama Toshinori

  Crest (core Research For Evolutional Science And Technology) Project Jst

• Kaga Chiaki

  Department Of Biotechnology School Of Engineering Nagoya University

• Okochi Mina

  Department Of Biotechnology School Of Engineering Nagoya University

• Hosokawa Hiroyuki

  Department Of Biotechnology Graduate School Of Engineering Nagoya University:mext Innovative Researc

• Honda Hiroyuki

  Department Of Quantum Engineering Nagoya University

• Honda Hiroyuki

  Graduate School Of Engineering Nagoya University

• Hosokawa Hiroyuki

  Department Of Immunology Graduate School Of Medicine Chiba University

• Honda Hiroyuki

  Department Of Chemical Engineering Faculty Of Engineering Nagoya University

• Nomura Shigeyuki

  Department Of Biotechnology School Of Engineering Nagoya University

• Nohara Takahiro

  Department Of Integrative Cancer Therapy And Urology Kanazawa University Graduate School Of Medical

• Suyama Kazuho

  Department Of Urology Kitasato University School Of Medicine

• Suyama Kazuho

  Departments Of Urology Kitasato University School Of Medicine

• Hamada Hirobumi

  Department Of Molecular Medicine Sapporo Medical University School Of Medicine

• Suyama Kazuho

  Department Of Urology Shintoshi Clinic

• Okochi Mina

  Department Of Biotechnology Nagoya University

• Hamada Hirobumi

  Department Of Biotechnology School Of Engineering Nagoya University

• Sentani Kazuhiro

  Department Of Molecular Pathology Hiroshima University Graduate School Of Biomedical Sciences

• Honda Hiroyuki

  Department Of Anesthesia Niigata City General Hospital

• Nagai Atsushi

  Department Of Neurology Hematology & Rheumatology Shimane University Faculty Of Medicine

• Nagai Atsushi

  First Department Of Medicine Tokyo Women's Medical University School Of Medicine

• Nagai Atsushi

  Department Of Laboratory Medicine Shimane University Faculty Of Medicine

• Nagai Atsushi

  Department Of Internal Medicine-1 Tokyo Women's Medical University

• Suzuki Kazuo

  National Aerospace Laboratory

• Suzuki Kazuo

  Gunma University

• Okochi Mina

  Department Of Biotechnology Graduate School Of Engineering Nagoya University

• Nagai Atsushi

  Department of Innovative and Engineered Materials, Tokyo Institute of Technology, J2-43, 4259 Nagatsuta-cho, Midori-ku, Yokohama 226-8502, Japan

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