Colominic Acid Production from Escherichia coli in a Fed-Batch Culture under the Control of Ammonium Ions Using an FIA System
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概要
- 論文の詳細を見る
A fed-batch culture was applied for the producton of colominic acid from Esherichia coli. It was found that the copper ion, which is a trace element in medium and an essential element in N-acetylneuraminic acid synthase, affected the colominic acid production and the highest production was obtained using 1.6 mg/l CuCl_2.Ammonia formed from nitrogen source utilization greatly affected colominic acid production and only slightly affected the cell growth. A flow injection analysis (FIA) system was fabricated and applied to monitor and control the ammonia concentration in the culture broth. It was found that a concentration of 0.3 g/l of ammonia was optimal for colominic acid production where 1.9 g/l was obtained.
- 社団法人日本生物工学会の論文
- 1997-01-25
著者
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Honda Hiroyuki
Department of Biotechnology, School of Engineering, Nagoya University
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KOBAYASHI Takeshi
Department of Electrical Engineering, Faculty of Engineering Science, Osaka University
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Honda Hiroyuki
Department Of Bioengineering Tokyo Institute Of Technology
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Honda Hiroyuki
Department Of Biotechnology Graduate School Of Engineering Nagoya University
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KOBAYASHI TAKESHI
(Present address) Department of Chemical Engineering, Faculty of Engineering, Nagoya University
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NAKAZEKO TAKUO
Department of Biotechnology, Garaduate School of Engineering, Nagoya University
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OGISO KOJI
Deaprtment of Biotechnology, Graduate School of Engineering, Nagoya University
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KAWASE YUJI
Research & Development Division of Environmental Plant Business Group, NGK Insulators Ltd.
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AOKI NOBUHIRO
Research & Development Division of Environmental Plant Business Group, NGK Insulators Ltd.
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KAWASE MITSUO
Research & Development Division of Environmental Plant Business Group, NGK Insulators Ltd.
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Ogiso Koji
Deaprtment Of Biotechnology Graduate School Of Engineering Nagoya University
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Kawase Yuji
Research & Development Division Of Environmental Plant Business Group Ngk Insulators Ltd.
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Aoki Nobuhiro
Research & Development Division Of Environmental Plant Business Group Ngk Insulators Ltd.
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Kawase Mitsuo
Research & Development Division Of Environmental Plant Business Group Ngk Insulators Ltd.
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Nakazeko Takuo
Department Of Biotechnology Garaduate School Of Engineering Nagoya University
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Kobayashi Takeshi
Department Of Biological Chemistry College Of Bioscience And Biotechnology Chubu University
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Kobayashi T
Dep. Of Biological Mechanisms And Functions Graduate School Of Bioagricultural Sciences Nagoya Univ.
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Kobayashi T
Univ. Tsukuba Ibaraki Jpn
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Kobayashi Takeshi
Dept.of Chemical Engineering Nagoya University
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Honda Hiroyuki
Department Of Anesthesia Niigata City General Hospital
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Kobayashi Takeshi
Department Of Chemical Engineering Faculty Of Engineering Nagoya University
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Kobayashi Takeshi
Department Of Biotechnology Graduate School Of Engineering Nagoya University
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Kobayashi Takeshi
Department Of Biotechnology:faculty Of Engineering Nagoya University
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KOBAYASHI TAKESHI
Department of Chemical Engineering, Faculty of Engineering, Nagoya University
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KOBAYASHI TAKESHI
Department of Biotechnology, Faculty of Engineering, Nagoya University
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