Prognostic Predictor with Multiple Fuzzy Neural Models Using Expression Profiles from DNA Microarray for Metastases of Breast Cancer(BIOINFORMATICS)
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概要
- 論文の詳細を見る
Gene expression profiling data from DNA microarray were analyzed using the fuzzy neural network (FNN) modeling method for predicting the distant metastases of breast cancer. The best model consisting of five genes was able to predict metastases of breast cancer with 94% accuracy. Furthermore, 100% accuracy was achieved by majoritarian decision using only 25 genes from five noninferior models which were constructed independently. From the constructed model, gene expression rules, which may cause distant metastases, were explicitly extracted and 60% of the metastases cases could be explained by this rule. The FNN modeling method described in this paper enables precise extraction of significant biological markers affecting prognosis without prior knowledge.
- 社団法人日本生物工学会の論文
- 2004-09-25
著者
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Honda Hiroyuki
Department of Biotechnology, School of Engineering, Nagoya University
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本多 裕之
名大院工・生物機能
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Kobayashi T
School Of Bioscience And Biotechnology Chubu University
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TAKAHASHI Hiro
Department of Biological Chemistry, College of Bioscience and Biotechnology, Chubu University
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高橋 広夫
中部大・応生・応生化
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KOBAYASHI Takeshi
Department of Electrical Engineering, Faculty of Engineering Science, Osaka University
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Kobayasi T
School Of Bioscience And Biotechnology Chubu University
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Honda Hiroyuki
Department Of Bioengineering Tokyo Institute Of Technology
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Kobayashi T
Graduate School Of Marine Science And Technology Tokyo University Of Marine Science And Technology
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ANDO Tatsuya
Department of Biotechnology, School of Engineering, Nagoya University
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MASUDA KAYOKO
Department of Biotechnology, School of Engineering, Nagoya University
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Kobayashi Takeshi
Department Of Biological Chemistry College Of Bioscience And Biotechnology Chubu University
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Kobayashi T
Dep. Of Biological Mechanisms And Functions Graduate School Of Bioagricultural Sciences Nagoya Univ.
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Takahashi Hiro
Department Of Biotechnology School Of Engineering Nagoya University
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Takahashi Hiro
Department Of Biological Chemistry College Of Bioscience And Biotechnology Chubu University
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Takahashi Hiro
Department Of Biotechnology School Of Engineering Nagoya University:(present Office)college Of Biosc
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Takahashi Hiro
Research Fellow Of The Japan Society For The Promotion Of Science (jsps):department Of Biotechnology
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Ando Tatsuya
Department Of Biotechnology School Of Engineering Nagoya University
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Masuda Kayoko
Department Of Biotechnology School Of Engineering Nagoya University
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高橋 広夫
中部大学応用生物学部植物バイオ研究センター
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高橋 広夫
Department Of Biological Chemistry College Of Bioscience And Biotechnology Chubu University
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Kobayashi T
Graduate School Of Engineering Science Osaka University
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Honda Hiroyuki
Department Of Anesthesia Niigata City General Hospital
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Takahashi Hiro
Department Of Advanced Bioscience Faculty Of Agriculture Kinki University
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Takahashi Hiro
Plant Biology Research Center Chubu University
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