Association Study between Apolipoprotein L and Schizophrenia by Exhaustive and Rule-Based Combination Analysis for Identification of Multilocus Interactions(BIOINFORMATICS)

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概要

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• Several single marker association and haplotypic analyses have been performed to identify susceptible genes for various common diseases, but these approaches using candidate genes did not provide accurate and consistent evidence in each analysis. This inconsistency is partly due to the fact that the common diseases are caused by complex interactions among various genetic factors. Therefore, in this study, to evaluate exhaustive genotype or allele combinations, we applied the binomial and random permutation test(BRP) proposed by Tomita et al. [IPSJ Digital Courier, 2, 691-709 (2006)] for the association analysis between an Apolipoprotein L gene cluster and schizophrenia. Using the seven selected representative single nucleotide polymorphisms(SNPs) based on the results of linkage disequilibrium evaluation, we analyzed 845 schizophrenic patients and 707 healthy controls, and investigated the validation of risk and protective factors with two randomly divided data sets. A comparative study of a method for analyzing the interactions was performed by conventional methods. Even if all the tested methods were used for analysis, the risk factor with a high significance was not commonly selected from both independent data sets. How- ever, the significant interactions for the protective factor against disease development were commonly obtained from both data sets by BRP analysis. In conclusion, although it is considered that the causality of schizophrenia is too complex to identify a susceptible interaction using a small sample size, it was suggested that the healthy controls tend to have the same combination of certain alleles or genotypes for protection from disease development when BRP as a new exhaustive combination analytical method was used.

• 社団法人日本生物工学会の論文
• 2007-04-25

著者

• Honda Hiroyuki

  Department of Biotechnology, School of Engineering, Nagoya University

• 本多 裕之

  名大院・工・生物機能

• 本多 裕之

  名大院工・生物機能

• Honda Hiroyuki

  Department Of Biotechnology Graduate School Of Engineering Nagoya University:mext Innovative Researc

• 本多 裕之

  Department Of Biotechnology School Of Engineering Nagoya University

• Tomita Yasuyuki

  Department of Biotechnology, School of Engineering, Nagoya University

• Mutoh Hironori

  Department of Biotechnology, School of Engineering, Nagoya University

• Ikeda Masashi

  Department Of Psychiatry Graduate School Of Medicine Fujita Health University

• Mutoh Hironori

  Department Of Biotechnology School Of Engineering Nagoya University

• Honda Hiroyuki

  Department Of Bioengineering Tokyo Institute Of Technology

• Honda Hiroyuki

  Department Of Biotechnology Graduate School Of Engineering Nagoya University

• Tamura Yasuaki

  Department Of Pathology School Of Medicine Sapporo Medical University

• Tomita Yasuyuki

  名古屋大学 工学部生物機能工学分野

• Tomita Yasuyuki

  Department Of Biotechnology School Of Engineering Nagoya University

• OZAKI Norio

  Department of Psychiatry, Nagoya University Graduate School of Medicine

• Tomita Yasuyuki

  Department Of Pathology School Of Medicine Sapporo Medical University

• Ozaki Norio

  Department Of Psychiatry Graduate School Of Medicine Nagoya University

• Ozaki Norio

  Department Of Psychiatry For Parents And Children Nagoya University Graduate School Of Medicine

• Hosokawa Hiroyuki

  Department Of Immunology Graduate School Of Medicine Chiba University

• Honda Hiroyuki

  Department Of Chemical Engineering Faculty Of Engineering Nagoya University

• Inada Toshiya

  Department of Psychiatry, Teikyo University School of Medicine Ichihara Hospital

• Iwata Nakao

  Department of Psychiatry, Fujita Health University School of Medicine

• Iwata Nakao

  Department Of Psychiatry Graduate School Of Medicine Fujita Health University

• Iwata Nakao

  Department Of Pharmacology Nagoya University School Of Medicine

• Inada Toshiya

  Department Of Psychiatry And Psychobiology Nagoya University Graduate School Of Medicine

• Inada Toshiya

  Seiwa Hospital Institute Of Neuropsychiatry

• Hamada Hirobumi

  Department Of Biotechnology School Of Engineering Nagoya University

• Honda Hiroyuki

  Department Of Anesthesia Niigata City General Hospital

• Ozaki Norio

  Department Of Developmental Neurobiology Tohoku University Graduate School Of Medicine

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