POTENTIATION OF TOXICITY AND POSITIVE INOTROPIC EFFECT OF OUABAIN BY FUROSEMIDE IN GUINEA PIG HEART

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概要

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• The present study was undertaken to elucidate the potentiation by furosemide of toxicity and positive inotropic effect of ouabain in guinea pigs. Arrhythmogenic responses to ouabain as well as the lowering of its lethal dose were potentiated by pretreatment with furosemide in guinea pigs. The potentiation of ouabain toxicity after furosemide administration was inhibited by pretreatment with potassium sparing diuretic, prorenoate. Furosemide-induced potentiations of contractile force and arrhythmogenic effect of ouabain were also observed in isolated guinea pig papillary muscle. However after pretreatment with furosemide, ouabain produced arrhythmias without any significant changes in either left ventricular or subcellular fractions binding of ^3H-ouabain in guinea pigs. These findings suggest that furosemide-induced potentiation of ouabain toxicity is at least in part associated with the decreased intracellular potassium content of guinea pig heart. It was also demonstrated that the positive inotropic action induced by subtoxic dose of ouabain was potentiated by furosemide in guinea pig papillary muscle preparation.

• 日本トキシコロジー学会の論文
• 1982-02-25

著者

• 小林 毅

  社会保険北海道健康保健管理センター

• MIYAMOTO Atsushi

  Department of Computer and Mathematical Sciences, Graduate School of Information Sciences, Tohoku Un

• Minami Masaru

  Department Of Pharmacology Faculty Of Pharmaceutical Sciences Health Sciences University Of Hokkaido

• Sakurai Masayuki

  Department of Cardiology, Hokko Memorial Hospital

• KOBAYASHI Takeshi

  Department of Electrical Engineering, Faculty of Engineering Science, Osaka University

• Togashi Hiroko

  Department of Pharmacology, Hokkaido University Graduate School of Medicine

• YASUDA HISAKAZU

  Department of Cardiovascular Medicine, Hokkaido University School of Medicine

• Togashi Hiroko

  Department Of Pharmacology Hokkaido University Graduate School Of Medicine

• Sakurai Masayuki

  Department Of Cardiovascular Medicine Hokkaido University School Of Medicine Sapporo Japan

• Saito Hideya

  Dept. Basic Sci. Jpn. Red Cross Hokkaido College Nursing:dept Pharmacol. Heallth Sci. Univ.

• Saito Hideya

  Department Of Cardiovascular Medicine And Pharmacology. Hokkaido University

• Satoh H

  Environmental Health Science Tohoku University Graduate School Of Medicine

• Saito Hideya

  Department Of Basic Sciences Japanese Red Cross Hokkaido College Of Nursing

• Saito Hideya

  Dept. Of Pharm. School Of Med. Hokkaido Univ.

• Yasuda Hisakazu

  Department Of Cardiology Hokkaido University School Of Medicine Sapporo

• MIYAMOTO Atushi

  Division of Cardiovascular Medicine. Hokkaido university School of Medicine

• Kanamori Katsushi

  Department of Cardiovascular Medicine, School of Medicine, Hokkaido University

• Miyamoto Atsushi

  Department Of Cardiovascular Medicine School Of Medicine Hokkaido University

• Kanamori Katsushi

  Dept. of cardiovascular med, Hokkaido univ.

• Kobayashi Takeshi

  Department Of Biological Chemistry College Of Bioscience And Biotechnology Chubu University

• Kobayashi Takeshi

  Department Of Cardiovascular Medicine Hokkaido University School Of Medicine

• Togashi Hiroko

  Department Of Cardiovascular Medicine Hokkaido University Graduate School Of Medicine

• Saito H

  Tohoku Univ. Sendai

• Kanamori Katsushi

  Department Of Cardiovascular Medicine School Of Medicine Hokkaido University

• Kanamori Katsushi

  Department Of Cardiovascuiar Medicine Hokkaido University Schooi Of Medicine Hokkaido University

• Yasuda Hisakazu

  Department Of Cardiovascular Medicine Hokkaido Univcrsity

• Minami Masaru

  Department Of Cardiovascular Medicine Hokkaido University School Of Medicine

• Minami Masaru

  Department Of Cardiovascular Medicine Hokkaldo University School Of Medicine

• Togashi Hiroko

  1st Dept. Of Pharmacol. Hokkaido Univ. Sch. Of Med.

• Sakurai Masayuki

  Dept. Of Cardiovascular Med. And First Dept. Of Pharmacology

• Sakurai Masayuki

  Department Of Cardiovascular Medicine Hokko Memorial Hospital

• Makita Masaaki

  Dept. Of Cardiovascular Med Hokkaido Univ.

• Takahashi Kihito

  Department Of Cardiovascular Medicine Hokkaido University School Of Medicine

• Minami Masaru

  Dept. Of Pharm. School Of Med. Hokkaido Univ.

• Satoh Hiroshi

  Environmental Health Science Tohoku University Graduate School Of Medicine

• Yasuda Hisakazu

  Department Of Cardiology Hokkaido University School Of Medicine

• Yasuda Hisakazu

  Department O F Cardiovascular Medicine Hokkaido University School Of Medicine

• Minami Masaru

  Department Of Cardiovascular Medicine 1st Department Of Internal Medicine Hokkaido University School

• KOBAYASHI Takeshi

  Department of Cardiovascular Medicine, School of Medicine, Hokkaido University

• KOBAYASHI Takeshi

  Department of Cardiovascular Medicine, Hokkaido University, School of Medicine

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