Diagnostic Value of ^<123>I-Betamethyl-p-Iodophenyl-Pentadecanoic Acid (BMIPP) Single Photon Emission Computed Tomography (SPECT) in Patients With Chest Pain : Comparison With Rest-Stress ^<99m>Tc-Tetrofosmin SPECT and Coronary Angiography
スポンサーリンク
概要
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Background Basic and clinical studies have indicated that 15-(p-[^<123>I] iodophenyl)-3-(R, S) methyrpentadecanoic acid (BMIPP) single photon emission computed tomography (SPECT) can identify ischemic myocardium without evidence of myocardial infarction by the regional decline of tracer uptake. The present study compared BMIPP SPECT with rest-stress myocardial perfusion imaging (MPI) findings and coronary angiography (CAG) in 150 patients with acute chest pain. Methods and Results Patients with acute chest pain who underwent all of the following tests were selected: MPI at rest-stress, BMIPP SPECT at rest and CAG. Organic coronary artery stenosis (≥75%) was observed in 46 patients, 27 patients had total or subtotal coronary occlusion by spasm in the spasm provocation test on CAG and the remaining 77 patients had no significant coronary artery stenosis or spasm. The sensitivity of BMIPP at rest to detect organic stenosis was significantly higher (54%) than that of rest-MPI (33%, p<0.005), but lower than that of stress-MPI (76%, p=0.05). The sensitivity of BMIPP at rest to detect spasm was significantly higher (63%) than that of both rest-MPI (15%; p<0.001) and stress-MPI (19%; p<0.001). Overall, the sensitivity of BMIPP at rest to detect both organic stenosis and spasm was significantly higher (58%) than that of rest-MPI (26%; p<0.001), despite having no significance with that of stress-MPI (55%). The specificity was not significantly different among the three imaging techniques. Conclusion Resting BMIPP SPECT is an alternative method to stress MPI for identifying patients with not only organic stenosis but also spasm without the need for a stress examination.
- 社団法人日本循環器学会の論文
- 2004-05-20
著者
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MORITA Koichi
Department of Virology, Institute of Tropical Medicine, Nagasaki University, and Core Research for E
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Tamaki Nagara
Department of Nuclear Medicine, Graduate School of Medicine, Hokkaido University
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Sakurai Masayuki
Department of Cardiology, Hokko Memorial Hospital
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Morita Koichi
台湾
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Morita Koichi
Department Of Nuclear Medicine Hokkaido University Graduate School Of Medicine
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Nakata Tomoaki
Second Department Of Internal Medicine Sapporo Medicine University
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Tamaki Nagara
Hokkaido University School Of Medicine Department Of Tracer Kinetics And Department Of Nuclear Medic
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Sakurai Masayuki
Department Of Cardiovascular Medicine Hokkaido University Graduate School Of Medicine
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Sakurai Masayuki
Department Of Cardiovascular Medicine Hokkaido University School Of Medicine Sapporo Japan
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Kawai Yuko
Department of Cardiovascular Medicine, Hokko Memorial Hospital
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Nozaki Yoichi
Department of Cardiovascular Medicine, Hokko Memorial Hospital
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Ohkusa Takanori
Department of Cardiovascular Medicine, Hokko Memorial Hospital
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Kawai Yuko
Hokko Memorial Hospital
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Nozaki Yoichi
Hokko Memorial Hospital
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Ohkusa Takanori
Hokko Memorial Hospital
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Morita Koichi
Department Of Forest And Forest Products Science Faculty Of Agriculture Kyushu University
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Kawai Yuko
Department Of Cardiology Hokkou Memorial Hospital
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Tamaki Nagara
Department Of Cardiology Shiga Prefecture Medical Center For Adult
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Tamaki Nagara
Hokkaido University Nuclear Medicine
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Sakurai Masayuki
Department Of Cardiovascular Medicine Hokko Memorial Hospital
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