Improvement in Fatty Acid Utilization in Relation to a Change in Left Ventricular Hypertrophy in Spontaneously Hypertensive Rats

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概要

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• Although fatty acid metabolism is reportedly impaired in myocardial hypertrophy, it is unclear whether the antihypertensive drugs are associated with improved fatty acid metabolism. In order to evaluate the effects of antihypertensive drugs on fatty acid metabolism and myocardial perfusion, the simultaneous uptake of iodine-125(^<125>I)-15-(p-iodophenyl)-3-(R,S)-methylpentadecanoic acid (BMIPP) and thallium-201 (Tl) were measured in 3 groups of rats: (1) spontaneously hypertensive rats (SHR) without treatment (SHR-N), (2) SHR chronically treated with captopril (SHR-C), and (3) SHR chronically treated with hydralazine (SHR-H). Captopril and hydralazine were administered to their respective groups for 3 weeks from 12 weeks of age. The hearts were removed 10 min after simultaneous intravenous injections of BMIPP and Tl and the ^<125>I and ^<201>Tl counts were measured to calculate the uptake ratio. The systolic blood pressure(SBP) in SHR-N was 222±10 mmHg, whereas the SHR-C and SHR-H groups showed significant SBP reduction (156±11, and 158±10 mmHg, respectively) (p<0.01 each). The heart/bodyweight ratio was significantly lower in SHR-C (2.48±0.09) than in SHR-N (2.74±0.11) (p<0.05). However, there was no significant difference in the heart/bodyweight ratio between SHR-N and SHR-H (2.65±0.09). The ratio of BMIPP uptake to Tl uptake (BMIPP/Tl) was significantly higher in SHR-C (0.71±0.13) than in SHR-N (0.50±0.09) (p<0.05). However, BMIPP/Tl in SHR-H (0.53±0.09) was similar to that in SHR-N. These results suggest that captopril improves fatty acid metabolism in the hypertrophied ventricle in SHR. The metabolic alterations may improve with left ventricular hypertrophy regression but are not effected by the reduction of blood pressure only.

• 社団法人日本循環器学会の論文
• 2000-01-20

著者

• ITOH Kazuo

  Department of Clinical Cariology, Showa University School of Dentistry

• Kitabatake Akira

  Department of Cardiovascular Medicine, Graduate School of Medicine, Hokkaido University

• Tamaki Nagara

  Department of Nuclear Medicine, Graduate School of Medicine, Hokkaido University

• Itoh K

  Radiology Jr Sapporo General Hospital

• Nakata Tomoaki

  Second Department Of Internal Medicine Sapporo Medicine University

• Kohya Tetsuro

  NTT East Japan Sapporo Hospital

• Kohya Tetsuro

  Department of Cardiovascular Medicine, Hokkaido University Graduate School of Medicine

• Tomita Fumishi

  Department of Cardiovascular Medicine, Hokkaido University, Graduate School of Medicine

• Itoh Yoshinori

  Department of Cardiovascular Medicine, Hokkaido University, Graduate School of Medicine

• Iwadou Yasuyoshi

  Departments Of Cardiovascular Medicine Graduate School Of Medicine Hokkaido University

• Itoh Yoshinori

  Department Of Cardiovascular Medicine Hokkaidou University Graduate School Of Medicine

• TSUKAMOTO Eriko

  Department of Nuclear Medicine, Hokkaido University Graduate School of Medicine

• Tamaki Nagara

  Hokkaido University School Of Medicine Department Of Tracer Kinetics And Department Of Nuclear Medic

• Tsukamoto Eriko

  Department Of Nuclear Medicine Hokkaido University Graduate School Of Medicine

• Tsukamoto Eriko

  Department Of Nuclear Medicine Hokkaido Unversity Graduate School Of Medicine

• Tsukamoto Eriko

  Department Of Nuclear Medicine Graduate School Of Medicine Hokkaido University

• MOCHIZUKI Takafumi

  Department of Nuclear Medicine, Hokkaido University, School of Medicine

• ONO Tomohide

  Department of Cardiovascular Medicine, Hokkaido University, School of Medicine

• Ono Tomohide

  Departments Of Cardiovascular Medicine Hokkaido University School Of Medicine

• Kitabatake Akira

  Department Of Cardicvascular Medicine Hokkaidou University

• Mochizuki Takafumi

  Departments Of Nuclear Medicine Hokkaido University School Of Medicine

• Kohya Tetsuro

  Department Of Cardiovascular Medicine Hokkaido University Graduate School Of Medicine

• Tamaki Nagara

  Department Of Cardiology Shiga Prefecture Medical Center For Adult

• Itoh Kiyotaka

  Department Of Surgical Oncology Division Of Cancer Medicine Hokkaido University Graduate School Of M

• Tomita Fumishi

  Department Of Cardiovascular Medicine Hokkaido University Graduate School Of Medicine

• Tamaki Nagara

  Hokkaido University Nuclear Medicine

• Kitabatake Akira

  Departments Of Cardiovascular Medicine Hokkaido University School Of Medicine

• Ito Kiyotaka

  Second Department Of Surgery Hokkaido University Hospital

• Itoh Yoshinori

  Department Of Cardiovascular Medicine Hokkaido University Graduate School Of Medicine

• Itoh Kazuo

  Department Of Cardiovascular Surgery Aomori General Hospital

• Iwado Yasuyoshi

  Department Of Cardiorenal And Cerebrovascular Medicine Kagawa University

• Itoh Yoshinori

  Department Of Cardiorenal And Cerebrovascular Medicine Kagawa University

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