Novel Estrogenic Microsomal Metabolites from Phthalate Esters

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概要

• 論文の詳細を見る

• Many researchers have found evidence of the estrogenic effects of phthalate esters (PEs), but the disruption mechanism is not fully elucidated. Once PEs are hydroxylated at the ring 4-position, the resulting compounds exhibit unequivocal binding affinity for human estrogen receptors. In this study, we first succeeded to demonstrate the generation of potent estrogenic metabolite from PEs. We used rat liver microsomes and dimethyl phthalate (DMP) as a representative for the metabolism of PEs. Among the metabolites detected by HPLC, one of them was consistent with an authentic compound, 4-hydroxylated DMP (DMP-4OH) on their HPLC profiles. Together with the UV (λmax = 257 nm) and MS (m/z 210) data, the metabolite was concluded to be DMP-4OH. We propose that this ring-hydroxylated metabolite could be a key active species in the endocrine disrupting processes of PEs.

• 公益社団法人日本薬学会の論文
• 2004-10-01

著者

• ITOH Kazuo

  Department of Clinical Cariology, Showa University School of Dentistry

• Itoh K

  Department Of Clinical Cariology Showa University School Of Dentistry

• Ueda Koji

  Faculty of Pharmacy, Meijo University

• Itoh Kazuo

  Faculty of Pharmacy, Meijo University

• Okamoto Yoshinori

  Faculty of Pharmacy, Meijo University

• Kojima Nakao

  Faculty of Pharmacy, Meijo University

• Hoshino K

  The Research Institute Of Environmental Medicine Nagoya University

• Toda Chitose

  Faculty of Pharmacy, Meijo University

• Toda Chitose

  Faculty Of Pharmacy Meijo University

• Kojima Nakao

  Exploratory Medicinal Sciences Pfizer Global Research And Development(pgrd)-nagoya Laboratories Pfiz

• Kojima Nakao

  Faculty Of Pharmacy Meijo University

• Kojima Nakao

  Central Research Division Pfizer Pharmaceuticals Inc.

• Okajima Kana

  Faculty of Pharmacy, Meijo University

• Hashizume Kiyomatsu

  Faculty of Pharmacy, Meijo University

• Okajima Kana

  Faculty Of Pharmacy Meijo University

• Hashizume Kiyomatsu

  Faculty Of Pharmacy Meijo University

• Hoshino K

  Univ. Tsukuba Tsukuba‐shi Jpn

• Okamoto Yoshinori

  Fac. Of Pharmacy Meijo Univ.

• Toda Chitose

  The Research Institute Of Environmental Medicine Nagoya University

• UEDA Koji

  Faculty of Agriculture, Yamagata University

• Kojima Nakao

  Faculty of Pharmaceutical Sciences, Kyoto University

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