Technetium-99m-labeled Recombinant Tissue Plasminogen Activator for the lmaging of Emboli In Vivo

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概要

• 論文の詳細を見る

• Tissue-type plasminogen activator (t-PA) effectively lyses active thrombus by direct action. Recombinant t-PA (rt-PA) was labeled with technetium-99m (^<99m>Tc) to investigate the in vivo binding to fibrin clots in a feline cerebral embolism model created by insertion of an artificial fibrin clot within the carotid artery. ^<99m>Tc-rt-PA administered intravenously provided clearer imaging of clots after priming with cold rt-PA, with uptake peaking 5-10 minutes after the injection. ^<99m>Tc-labeled human serum albumin was not retained at clot sites. Systemically administered ^<99m>Tc-rt-PA binds to fibrin clots within carotid arteries in our feline model. Our results suggest that the interaction of intrinsic plasminogen activator inhibitors with extrinsically administered rt-PA may regulate the demonstration of a clot, although the precise mechanism is unclear.

• 日本脳神経外科学会の論文
• 1993-07-15

著者

• KAMIYAMA Hiroyasu

  Department of Neurosurgery, Asahikawa Red Cross Hospital

• ITOH Kazuo

  Department of Clinical Cariology, Showa University School of Dentistry

• Abe Hiroshi

  Department Of Cardiology National Cardiovascular Center

• Takahashi Akihiro

  Department of Internal Medicine, Kobe University School of Medicine

• Itoh K

  Radiology Jr Sapporo General Hospital

• Abe Hiroshi

  Department Of Neurosurgery Hokkaido University Graduate School Of Medicine

• TSUKAMOTO Eriko

  Department of Nuclear Medicine, Hokkaido University Graduate School of Medicine

• Tsukamoto Eriko

  Department Of Nuclear Medicine Hokkaido University Graduate School Of Medicine

• Tsukamoto Eriko

  Department Of Nuclear Medicine Hokkaido Unversity Graduate School Of Medicine

• Tsukamoto Eriko

  Department Of Nuclear Medicine Graduate School Of Medicine Hokkaido University

• FURUDATE Masayori

  Department of Nuclear Medicine, Hokkaido University School of Medicine

• Furudate Masayori

  Department Of Nuclear Medicine Hokkaido University School Of Medicine

• Takahashi Akihiro

  Department Of Neurosurgery University Of Hokkaido School Of Medicine:(present Address)department Of

• Abe Hiroshi

  Department Of Neurosurgery University Of Hokkaido School Of Medicine

• Itoh Kiyotaka

  Department Of Surgical Oncology Division Of Cancer Medicine Hokkaido University Graduate School Of M

• Abe Hiroshi

  Department Of Neurosurgery Hokkaido University School Of Medicine

• Abe Hiroshi

  Department Of Anatomy Akita University School Of Medicine

• Kamiyama Hiroyasu

  Department Of Neurosurgery University Of Hokkaido School Of Medicine

• Kamiyama Hiroyasu

  Department Of Neurosurgery Asahikawa Red Cross Hospital

• Ito Kiyotaka

  Second Department Of Surgery Hokkaido University Hospital

• Itoh Kazuo

  Department Of Cardiovascular Surgery Aomori General Hospital

• Abe Hiroshi

  Department Of Neurosurgery Hokkaido University School Of Medicine And Sapporo Azabu Neurosurgical Ho

• Abe Hiroshi

  Department Of Agricultural Chemistry Faculty Of Agriculture Tohoku University

• Kamiyama Hiroyasu

  Department Of Neurosurgery Asahiakawa Red Cross Hospital

• Takahashi Akihiro

  Department Of Chemistry Faculty Of Fisheries Hokkaido University

• Furudate Masayori

  Department Of Human Health Sciences Graduate School Of Medicine Kyoto University

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