<111>^In Monoclonal Antimyosin Antibody Imaging : Imaging of Myocardial Infarction and Myocarditis : 53th Annual Scientific Session of the Japanese Circulation Society

概要

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A new scintigraphic method to detect myocardial necrosis has been developed using antimyosin monoclonal antibody Fab labeled with indium-111. Using this method, we studied 35 patients with myocardial infarction, 5 patients with myocarditis and 3 patients with angina pectoris. ^<111>In antimyosin Fab was administered intravenously and antimyosin images were recorded by planar and single photon emission computed tomography (SPECT) 48 hours after injection. Planar images showed discrete localization ^<111>In antimyosin in 25 of 26 patients within 14 days after the onset of acute myocardial infarction. In 14 of these patients creatine kinase, glutamic oxaloacetic transaminase and lactic dehydrogenase had already normalized. Positive scans were also obtained in 6 of 12 patients between the third week to the ninth year after the onset of the disease. Three patients with acute myocarditis has positive scans 2 and 4 weeks after the onset of the disease. Thus,^<111>In antimyosin imaging may be a useful noninvasive method for the diagnosis of coronary diseases and myocarditis. Although the mechanism of persistent positive antimyosin images in the chronic stage remains to be clarified, ^<111>In antimyosin scintigraphy holds potential promise as a noninvasive method for the detection of myocardial injury in the subacute to chronic stage as well as in the acute stage.
社団法人日本循環器学会の論文
1990-03-20