Effects of Cardiac Sympathetic Nervous System on the Stunned Myocardium Experimental Study with ^<123>I-metaiodobenzylguanidine : 54th Annual Scientific Session of the Japanese Circulation Society

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^<123>I-Metaiodobenzylguanidine (^<123>I-MIBG) uptake in the stunned myocardium was investigated in open chest dogs. ^<123>I-MIBG is a tracer taken up in presynaptic adrenergic vesicles and reflects the function of the myocardial sympathetic nervous system. This study revealed that in the stunned myocardium without infarct , ^<123>I-MIBG uptake was normal up to 40 minutes of ischemia and that exogenous noradrenaline improved deteriolated regional wall motion with increased uptake of ^<123>I-MIBG. However, uptake of ^<123>I-MIBG per flow decreased with infarct in ischemic areas, and it showed a linear relation with regional wall motion. Thus, in the absence of infarction ^<123>I-MIBG is a tracer to differentiate stunning from more severe ischemia with persistent wall motion abnormality. Normal uptake and storage of ^<123>I-MIBG in the stunned condition suggests that catecholamine release or second effector mechanism may replate to the mechanism.
社団法人日本循環器学会の論文
1991-09-20