Effects of Intracoronary Thrombolysis on Infarct Size and Left Ventricular Function in Patients with Anterior Myocardial Infarction : Enzymatic, Electrocardiographic,Radionuclide and Hemodynamic Evaluations : PANEL DISCUSSION ONINTRACORONARY THROMBOLYSIS
スポンサーリンク
概要
- 論文の詳細を見る
The influence of the duration of ischemia on infarct size and left ventricular function (LV) was assessed in 30 patients with a first anterior myocardial infarction (MI) and intracoronary thrombolysis (ICTL) on admission. The occlusion time of the left anterior descending coronary artery (LAD) was 4 hours or less in 11 patients (group I), 4-10 hours in 11 (group II) and 10 hours or more in eight (group III). Serial measurements of serum creatine kinase-MB were carried out during the acute phase. Four weeks after the procedure, electrocardiographic pathological Q waves on 34-lead precordial mapping were scored, viable left ventricular myocardial volume and the ratio of infarcted to total left ventricular myocardial volume was estimated by myocardial emission computed tomography (ECT) with thallium-201. In the acute phase enzymatic estimation of infarct size showed a significant difference between group I and the other two groups but not between groups II and III; there were no significant differences in the degree of left ventricular asynergy among the three groups. In the chronic phase infarct sizes evaluated by both Q wave mapping and ECT were smaller in group I than those in group II, which were smaller than those in group III; there were significant differences in the degree of LV asynergy among the three groups (group I II III). LV function was nearly normal in group I, moderately impaired in group II, but severely depressed in group III 4 weeks later. The present study indicates that infarct size extends and LV function deteriorates with the duration of occlusion of the LAD and that not only early (⩽ 4 hours) but also later (4-10 hours) reperfusion is beneficial to prevent the extension of MI and deterioration of LV function in patients with anterior MI.
- 社団法人日本循環器学会の論文
- 1985-06-20
著者
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Kambara Hirofumi
The Kyoto And Shiga Myocardial Infarction (kysmi) Study Group:cardiovascular Center Osaka Red Cross
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Kambara Hirofumi
大阪赤十字病院
-
Kohagura Kentaro
琉球大学 第三内科
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Kohagura Kentaro
琉球大学医学部附属病院 血液浄化療法部
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KAMBARA Hirofumi
Osaka Red Cross Hospital
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TAMAKI Shunichi
Takeda Hospital
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MURAKAMI TOMOYUKI
The Third Division, Department of lnternal Medicine, Kyoto University Hospital
-
Tamaki Shunichi
Cardiology Division Takeda Hospital
-
KAWAI Chuichi
Takeda General Hospital
-
Kishimoto Chiharu
Third Division Of Internal Medicine Kyoto Univercity Hospital.
-
Kambara Hirofumi
The 3rd Division Department Of Internal Medicine Faculty Of Medicine Kyoto University
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Kishimoto C
Department Of Cardiovascular Medicine Graduate School Of Medicine Kyoto University
-
Takatsu Yoshiki
Third Division Department Of Internal Medicine Faculty Of Medicine Kyoto University
-
Kadota Kazunori
Takeda Hospital
-
Kadota Kazunori
Osaka Police Hospital
-
Kodama Kazuhisa
Internal Medicine Nephrology And Hypertension St. Marianna University School Of Medicine
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MURAKAMI TOMOYUKI
Takeda Hospital and Third Division, Department of Internal Medicine, Kyoto University Hospital
-
KAMBARA HIROFUMI
Takeda Hospital and Third Division, Department of Internal Medicine, Kyoto University Hospital
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NAKAMURA YASUYUKI
Takeda Hospital and Third Division, Department of Internal Medicine, Kyoto University Hospital
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KISHIMOTO CHIHARU
Takeda Hospital and Third Division, Department of Internal Medicine, Kyoto University Hospital
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NOHARA RYUJI
Takeda Hospital and Third Division, Department of Internal Medicine, Kyoto University Hospital
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HATTORI RYUICHI
Takeda Hospital and Third Division, Department of Internal Medicine, Kyoto University Hospital
-
TAKATSU YOSHIKI
Takeda Hospital and Third Division, Department of Internal Medicine, Kyoto University Hospital
-
Kambara Hirofumi
The Third Division Department Of Internal Medicine Kyoto University
-
Murakami Tomoyuki
The Third Division Department Of Lnternal Medicine Kyoto University Hospital
-
Kanatsu Kazuro
Department Of Internal Medicine Hyogo Hospital
-
Mukai Takao
Dept. Of Radiology And Nuclear Medicine Kyoto University School Of Medicine
-
Kadota K
Department Of Internal Medicine Hyogo Hospital
-
Murakami Tomoyuki
Dept. Of Radiology And Nuclear Medicne And Internal Medicine Kyoto University
-
Kanatsu Kazuro
Third Division Department Of Internal Medicine Faculty Of Medicine Kyoto University
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Kamabara Hirofumi
Osaka Red Cross Hospital
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Kanatsu Kazuro
3rd Div. Dept. Of Intern. Med. Kyoto Univ. Hosp.
-
Hattori Ryuichi
Takeda Hospital And Third Division Department Of Internal Medicine Kyoto University Hospital
-
Kohagura Kentaro
Department Of Cardiovascular Medicine Nephrology And Neurology Faculty Of Medicine And Dialysis Unit
-
Nakamura Yasuyuki
Takeda Hospital And Third Division Department Of Internal Medicine Kyoto University Hospital
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Kambara H
Kyoto University
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Nohara Ryuji
Kyoto Univ. Hospital
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