EVALUATION AND CLINICAL USE OF EARLY WASHOUT RATIO OF THALLIUM-201 IN NORMAL AND ISCHEMIC MYOCARDIUM AFTER DIPYRIDAMOLE-INDUCED VASODILATION USING RING-TYPE EMISSION COMPUTED TOMOGRAPHY

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概要

• 論文の詳細を見る

• Using newly developed ring-type emission computed tomography (SPECT), we investigated the washout ratio (WR) of Tl-201 in the myocardium quantitatively with fast dynamic scanning after infusion of dipyridamole (0.57mg/kg), and assessed the feasibility of early WR as a marker to detect coronary artery disease. Twenty-three patients with and 8 patients without coronary aryery disease had serial SPECT images obtained every 5 min for 45 min and at 180 min after dipyridamole and subsequent Tl-201 injection. The best appropriate transaxial slice was selected for WR analysis. Most appropriate diagnostic time was 25 min after infusion of Tl-201 (WR-25). Normal WR-25 was 7.1±4.0%. 5.9±3. 1% and 7.1±2.3%, at the septum, anterior and lateral wall, respectively. Sensitivity, specificity and accuracy to identify coronary stenosis > 50% with a usage of abnormal WR-25, defined as WR-25 < (mean of normals - 1 SD) in each region of inferest of the left ventricle (LV), were 96%. 100% and 97%. respectively. These results were better than those achieved by visual analysis (sensitivity 78%, specificity 100%, accuracy 84%). In patients with single as well as multivessel disease, the regional accuracy in assessing stenosis of more than 50% in the left anterior descending artery (LAD) and left circumflex artery (LCX) by WR-25 was 940/c and 83%, respectively, which was significant-ly better than using visual methods (LAD 72% and LCX 50%; p<0.05). Thus, evaluation of early washout ratios (WR-25) after dipyridamole injection is a valuable method to increase sensitivity in assessing regional myocardial perfu-sion abnormality and is helpful in detection of ischemic heart disease, even with multivessel disease.

• 社団法人日本循環器学会の論文
• 1991-03-20

著者

• Takahashi N

  Department Of Cardiology Shiga Prefecture Medical Center For Adult

• Takahashi N

  Department Of Radiology Fukui Medical University

• Kambara Hirofumi

  The Kyoto And Shiga Myocardial Infarction (kysmi) Study Group:cardiovascular Center Osaka Red Cross

• Kambara Hirofumi

  大阪赤十字病院

• KAMBARA HIROFUMI

  Third Division, Department of Internal Medicine Faculty of Medicine, Kyoto University

• NOHARA RYUJI

  Third Division, Department of Internal Medicine Faculty of Medicine, Kyoto University

• KAWAI CHUICHI

  Third Division, Department of Internal Medicine Faculty of Medicine, Kyoto University

• KAMBARA Hirofumi

  Osaka Red Cross Hospital

• KAMBARA HIROFUMI

  College of Medical Technology and Research Center for Biomedical Engineering

• FUDO TETSURO

  Cardiac Service of Takeda Hospital

• HAYASHI MASATAKA

  Third Division, Department of Internal Medicine, and Department of Nuclear Medicine

• FUDO TETSURO

  Third Division, Department of Internal Medicine, and Department of Nuclear Medicine

• HASHIMOTO TETSUO

  Third Division, Department of Internal Medicine, and Department of Nuclear Medicine

• TAMAKI NAGARA

  Kyoto University Hospital

• YONEKURA YOSHIHARU

  Kyoto University Hospital

• KONISHI JUNJI

  Third Division, Department of Internal Medicine, and Department of Nuclear Medicine

• Kambara Hirofumi

  Kyoto University

• Fujita Toru

  Cardiac Service Of Takeda Hospital

• Kawai Chuichi

  The Japan Multicenter Investigation For Cardiovascular Diseases-b (jmic-b) Study Group

• Kawai Chuichi

  京都大学 第3内科

• Kawai Chuichi

  京都大学 医学研究科循環器内科学

• Hayashi Masataka

  Third Division Department Of Internal Medicine And Department Of Nuclear Medicine

• Kawai C

  The Japan Multicenter Investigation For Cardiovascular Diseases-b (jmic-b) Study Group

• Tamaki Nagara

  公立高島総合病院

• Hashimoto Tetsuo

  康生会武田病院 循環器科

• Hashimoto Tetsuo

  Division Of Cardiology Kyoto Takeda Hospital

• Hata Tatsuhiko

  京都大学 医研究 循環病態

• Kawai Chuichi

  Third Division Department Of Internal Medicine Faculty Of Medicine Kyoto University

• Tamaki N

  Hokkaido Univ.

• Takahashi Norio

  Department Of Radiology Fukui Medical University

• Tamaki Nagara

  Kyoto University School Of Medicine

• Konishi Junji

  京都大学 医学研究科心臓血管外科学

• NAGATA Tamotsu

  Shiga University of Medical Science

• Fudo Tetsuro

  Kyoto University School of Medicine

• Nohara Ryuji

  Third Division Department Of Internal Medicine Faculty Of Medicine Kyoto University

• Tamaki Nagara

  The Third Division Department Of Nuclear Medicine Kyoto University Hospital

• Takahashi Norio

  Departments Of Radiology Fukui Medical University

• Kambara Hirofumi

  The 3rd Division Department Of Internal Medicine Faculty Of Medicine Kyoto University

• Nohara Ryuji

  Third Division Department Of Internal Medicine Kyoto University Faculty Of Medicine

• Tamaki Nagara

  Department Of Radiology Fukui Medical University

• Tamaki Nagara

  Faculty Of Medicine Kyoto University

• Fudo Tetsuro

  Third Div. Dept. Of Internal Medicine Kyoto University Hospital

• Nakamura Takuji

  Department Of Cardiology Shiga Prefecture Medical Center For Adult

• Hashimoto Tetsuo

  Kyoto Japan

• Kambara Hirofumi

  The Third Division Department Of Internal Medicine Kyoto University

• Kawai Chuichi

  3rd Div. Dept Of Intern Med. Kyoto Univ

• Hoshino Tsuneo

  The 3rd Dept. Of Internal Medicine Kyoto Univ. Hospital

• Nakamura Takuji

  Department Of Cardiovascular Medicine Shiga Medical Center For Adults

• Kambara Hirofumi

  Third Division Department Of Internal Medicine Faculty Of Medicine Kyoto University

• Kamabara Hirofumi

  Osaka Red Cross Hospital

• Kawai Chuichi

  Third Department Of Internal Medicine Kyoto University Faculty Of Medicine

• Hashimoto Tetsuo

  Department Of Cardiovascular Medicine Graduate School Of Medicine

• Hirai Taku

  Division Of Cardiovascular Medicine Kyoto University

• Kambara H

  Kyoto University

• Nohara Ryuji

  Kyoto Univ. Hospital

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