EFFECT ON EXERCISE TOLERANCE AND PHARMACOKINETICS OF CONVENTIONAL AND SUSTAINED RELEASE PREPARATIONS OF PROPRANOLOL IN PATIENTS WITH ANGINA PECTORIS : A Double-blind Cross-over Study
スポンサーリンク
概要
- 論文の詳細を見る
Ten patients with effort angina were studied in a randomized double-blind cross-over trial in order to investigate the effect of sustained release propranolol (LA) and conventional propranolol (Prop) formulations on exercise tolerance. LA was given once daily and Prop three times daily. Treadmill exercise tests were performed using the Bruce protocol and the plasma propranolol levels were measured. The following results were obtained: 1) LA proved to have an anti-anginal effect similar to Prop. No adverse reactions were observed after administration of either of the drugs. 2) Similar suppressive effect of the heart rate, blood pressure and double product at rest and on exercise was seen after LA and Prop while the exercise capacity was increased. 3) The plasma level of propranolol was higher at 2 hours after Prop than LA administration, but there was no difference between LA and Prop at 4 and 24 hours after administration. 4) The plasma propranolol level at 4 hours after LA correlated with the percent reduction in exercise heart rate and with the percent reduction in the double product. Our study suggested that once-a-day administration of LA could improve patients' compliance and adds another choice to the list of clinically useful β-blockers for the treatment of angina pectoris on effort.
- 社団法人日本循環器学会の論文
- 1984-10-20
著者
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Kambara Hirofumi
The Kyoto And Shiga Myocardial Infarction (kysmi) Study Group:cardiovascular Center Osaka Red Cross
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Kambara Hirofumi
大阪赤十字病院
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Kohagura Kentaro
琉球大学 第三内科
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KAMBARA HIROFUMI
Third Division, Department of Internal Medicine Faculty of Medicine, Kyoto University
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KAMBARA Hirofumi
Osaka Red Cross Hospital
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Kawai Chuichi
Third Division Department Of Internal Medicine Faculty Of Medicine Kyoto University
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Kinoshita Masahiko
The First Department of Internal Medicine, Shiga University of Medical Science
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Kadota Kazunori
Third Division, Dept. of Internal Medicine, Kyoto Univ. Hospital
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Kambara Hirofumi
The 3rd Division Department Of Internal Medicine Faculty Of Medicine Kyoto University
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Kadota Kazunori
Osaka Police Hospital
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Kodama Kazuhisa
Internal Medicine Nephrology And Hypertension St. Marianna University School Of Medicine
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HIROTA YUZOU
The Third Department of Internal Medicine, Osaka Medical College
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SAWAMURA MATSUHIKO
The First Department of Internal Medicine, Shiga University of Medical Science
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SAITO TAKAHARA
The Third Department of Internal Medicine, Osaka Medical College
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Kinoshita Masahiko
The Kyoto And Shiga Myocardial Infarction (kysmi) Study Group:1st Division Of Internal Medicine Shig
-
Kinoshita Masahiko
The First Department Of Internal Medicine Shiga Medical College
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Kambara Hirofumi
The Third Division Department Of Internal Medicine Kyoto University
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Sawamura Matsuhiko
The First Department Of Internal Medicine Shiga University Of Medical Science
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Hirota Yuzo
The Third Department Of Internal Medicine Osaka Medical College
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Saito T
The Third Department Of Internal Medicine Osaka Medical College
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Kadota Kazunori
Third Division Department Of Internal Medicine Faculty Of Medicine Kyoto University
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Kadota K
Department Of Internal Medicine Hyogo Hospital
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Kambara Hirofumi
Third Division Department Of Internal Medicine Faculty Of Medicine Kyoto University
-
Kanatsu Kazuro
Third Division Department Of Internal Medicine Faculty Of Medicine Kyoto University
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Kamabara Hirofumi
Osaka Red Cross Hospital
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Kawai Chuichi
Third Department Of Internal Medicine Kyoto University Faculty Of Medicine
-
Kanatsu Kazuro
3rd Div. Dept. Of Intern. Med. Kyoto Univ. Hosp.
-
Kinoshita Masahiko
The First Department Of Internal Medicine
-
Kohagura Kentaro
Department Of Cardiovascular Medicine Nephrology And Neurology Faculty Of Medicine And Dialysis Unit
-
Kambara H
Kyoto University
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