Hypoadiponectinemia is Associated With Impaired Glucose Tolerance and Coronary Artery Disease in Non-Diabetic Men
スポンサーリンク
概要
- 論文の詳細を見る
Background Impaired glucose tolerance (IGT) is a significant risk factor for cardiovascular disease, but is not always recognized in the clinical setting. An anti-atherogenic adipocytokine, adiponectin, is decreased in type 2 diabetes mellitus, but its role in non-diabetic subjects has not been clarified. The hypothesis investigated in the present study was that plasma adiponectin levels correlate with IGT and coronary artery disease (CAD) in non-diabetic men. Methods and Results Glucose intolerance was evaluated by an oral glucose tolerance test and plasma adiponectin levels were measured in 232 non-diabetic men who underwent coronary angiography. Patients with IGT (n=102) had significantly lower adiponectin levels than those with normal glucose tolerance (n=130) (4.47 [3.23-6.39] vs 5.85 [3.99-8.65]μg/ml, p=0.003). Plasma adiponectin levels were associated with IGT in multiple logistic regression analysis (odds ratio (OR) 0.623, 95% confidence interval (CI) 0.397-0.980; p=0.041). Non-diabetic patients with CAD (n=122) had lower adiponectin levels than those without CAD (n=110) (4.60 [3.32-6.38] vs 6.08 [4.10-9.88]μg/ml, p<0.001). Multiple logistic regression analysis demonstrated adiponectin independently correlated with the presence of CAD (OR 0.432, 95% CI 0.256-0.728; p=0.002). Conclusions Hypoadiponectinemia is associated with IGT and CAD in non-diabetic men, suggesting that the adiponectin level can provide valuable information regarding the risk of CAD even in non-diabetic subjects. (Circ J 2007; 71: 1703-1709)
- 社団法人日本循環器学会の論文
- 2007-10-20
著者
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Ogawa Hisao
Department of Cardiology, Kumamoto University
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Yoshimura Michihiro
Department of Caldiology Jikei University School of Medisine
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Yasujima Minoru
Kobe University
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Maruyoshi Hidetomo
Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University
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Kojima Sunao
Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University
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Sakamoto Tomohiro
Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University
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KIMURA Kazuo
Division of Cardiology, Yokohama City University Medical Center
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UMEMURA Satoshi
Yokohama City University
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Yoshimura Michihiro
Division Of Cardiology Kumamoto University School Of Medicine
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Maruyoshi Hidetomo
Department Of Cardiovascular Medicine Graduate School Of Medical Sciences Kumamoto University
-
Sugiyama Seigo
Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University
-
Funahashi Tohru
Division Of Cardiovascular Surgery Department Of Surgery Osaka University Graduate School Of Medicin
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Funahashi Tohru
Department of Metabolic Medicine, Graduate School of Medicine
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Otsuka Fumiyuki
Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University
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Umemura Satoshi
Division of Cardiology, Yokohama City University Medical Center
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Sugiyama Seigo
Department Of Cardiovascular Medicine Graduate School Of Medical Science Kumamoto University
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Yasujima Minoru
東北大学 医系研究内部障害学分野
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Yasujima M
Department Of Laboratory Medicine Hirosaki University Graduate School Of Medicine
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Otsuka Fumiyuki
Department Of Cardiovascular Medicine Graduate School Of Medical Sciences Kumamoto University
-
Kamide Kei
Department Of Geriatric Medicine Ehime University Graduate School Of Medicine
-
Kojima Sunao
Department Of Cardiovascular Medicine Graduate School Of Medical Sciences Kumamoto Uinversity
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Funahashi Tohru
理化学研究所ゲノム医科学研究センター 内分泌･代謝疾患チーム
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Funatsu Toshihiro
Division Of Cardiovascular Surgery Department Of Surgery Osaka University Graduate School Of Medicin
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Ohtsuka Fumiyuki
Department Of Cardiovascular Medicine Graduate School Of Medical Sciences Kumamoto Uinversity
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Kohagura Kentaro
琉球大学 第三内科
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Sakamoto Tomohiro
Keio University School Of Medicine
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Sato Takahiro
Division Of Cardiology Saiseikai Kumamoto Hospital Cardiovascular Center
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Ootsuka Fumiyuki
Division Of Cardiology Yokohama City University Medical Center
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Fujisawa Toshio
Division Of Gastroenterology Yokohama City University School Of Medicine
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Yasujima M
Division Of Cardiology Department Of Internal Medicine The Jikei University School Of Medicine
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Funahashi Tohru
Department Of Internal Medicine And Molecular Science Graduate School Of Medicine
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Fujisato Toshiya
Department Of Organ Transplantation Cardiovascular Surgery National Cardiovascular Center
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Kimura Kazuo
Division Of Cardiology Yokohama City University Medical Center
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Umemura Satoshi
Division Of Cardiology Yokohama City University Medical Center
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Funahashi Tohru
Department Of Internal Medicine And Molecular Science Osaka University Graduate School Of Medicine
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Yoshimura Michihiro
Department Of Cardiovascular Medicine Graduate School Of Medical Sciences Kumamoto University
-
Morigami Yasuhiro
Department Of Atherosclerosis And Diabetes National Cardiovascular Center
-
Satoh Toru
Division Of Cardiology Saiseikai Kumamoto Hospital Cardiovascular Center
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Yasujima Minoru
Division Of Cardiology Department Of Internal Medicine The Jikei University School Of Medicine
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Ogawa Hisao
Department Cardiovascular Medicine Kumamoto University:division Of Intensive Care Unit Kumamoto Univ
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Umemura S
Department Of Second Internal Medicine Yokohama City University School Of Medicine
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Maruyoshi Hidetomo
Department Of Bioscience Department Of Cardiovascular Surgery
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Funahashi Tohru
Department Of Cardiovascular Surgery National Cerebral And Cardiovascular Center
-
Sakamoto Tomohiro
Cardiopulmonary Division School Of Medicine Keio University
-
Fukunaga Takashi
熊本大学 医学教育部循環器病態学
-
Maruyama Hideki
Division Of Cardiology Minamata City Hospital And Medical Center
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SAKAMOTO Tomohiro
Department of Cardiovascular Medicine, Graduate School of Medical Sciences Kumamoto University
-
Sakamoto Tomohiro
Department of Cardiology, Saiseikai Kumamoto Hospital, Japan
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