Prognostic Value of 1-Day Stress/Rest Electrocardiogram-Gated Single-Photon Emission Computed Tomography Using Tc-99m-Labeled Methoxy-Isobutyl Isonitrile

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To evaluate the prognostic value of the simultaneous assessment of perfusion and left ventricular wall motion, exercise non-gated/rest electrocardiogram(ECG)-gated ^<99m>Tc methoxy-isbutyl isonitrile(MIBI)single-photon emission computed tomography(SPECT)was performed in 182 patients suspected of having coronary artery disease.After injection of 250 MBq of ^<99m>Tc-MIBI at peak exercise, stress perfusion images were classified into 3 groups:normal, equivocal, and abnormal.Normal subjects completed the 1-day protocol but not the resting study, whereas patients with abnormal or equivocal perfusion images underwent ECG-gated SPECT study with injection of 750 MBq of ^<99m>Tc-MIBI 3 h later.Patients with normal perfusion during this protocol had a benign prognosis.Only 4 soft events occurred in the normal group(4.8%).In contrast, patients with both myocardial infarction and abnormal wall motion at rest experienced more cardiac events(7 cardiac events including 1 cardiac death among a total of 45 patients;15.6%, p<0.05 compared with normal subjects).In addition, ischemic patients also experienced more cardiac events(7 events including 2 cardiac deaths among a total of 25 subjects;28.0%, p<0.01 compared with normal patients).Our data suggest that the simultaneous assessment of perfusion and wall motion by stress/rest ECG-gated ^<99m>Tc-MIBI SPECT is a reliable indicator of prognosis in patients suspected of having coronary artery disease.
社団法人日本循環器学会の論文
1998-05-20

Prognostic Value of 1-Day Stress/Rest Electrocardiogram-Gated Single-Photon Emission Computed Tomography Using Tc-99m-Labeled Methoxy-Isobutyl Isonitrile

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