Prognostic Determinants of Hypertrophic Cardiomyopathy : The Results of the Shiga Cardiomyopathy Study

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概要

• 論文の詳細を見る

• Previous studies have reported that patients with hypertrophic cardiomyopathy (HCM) are prone to sudden death. In this study, we retrospectively assessed the prognosis and any influencing factors in 83 patients (66 male, 17 female) with HCM. Twenty-two patients were obstructive, 40 were non-obstructive, 18 were apical HCM and 3 were unclassified. Four of the 83 cases progressed to left ventricular dilatation and dysfunction during the follow-up period. The mean age was 51.2 years (range 16 to 73) and the mean duration of follow-up was 6.7 years (range 0.3 to 15.1). The 5- and 10-year survival rates were 98% and 89%, respectively. Five patients died; 3 from cardiac events (two sudden deaths and one due to congestive heart failure) and 2 from malignant diseases. The lack of a family history of sudden death and the amplitude of the S wave in lead V_1 (less than 2.0 mV) were associated with a favorable prognosis. None of the patients who were diagnosed before age 50 died, but this observation was not statistically significant. None of the patients with apical HCM died, but the classification of HCM was not significantly associated with the prognosis. None of the patients without medication died and medical treatment did not influence the prognosis. Sex, family history of HCM, the patient's symptoms and physical signs, NYHA classification of cardiovascular disability, thickness of the septum and the posterior wall of the left ventricle, dimension of the left atrium, and the left and right ventricles in echocardiogram, amplitude of the R wave in lead V_5, the depth of the negative T wave and atrial fibrillation did not influence the prognosis.

• 社団法人日本循環器学会の論文
• 1995-10-20

著者

• Kinoshita Masahiko

  First Department of Internal Medicine, Shiga University of Medical Science

• Kinoshita Masahiko

  Division Of Cardiology Department Of Medicine Shiga University Of Medical Science

• Nakamura Yasuyuki

  First Department of Internal Medicine, Shiga University of Medical Science

• Yoshida Michiaki

  First Department of Internal Medicine, Shiga University of Medical Science

• Higashikawa Masahito

  First Department of Internal Medicine, Shiga University of Medical Science

• Fukuhara Takehisa

  Fukuhara Clinic

• Nakamura Yasuyuki

  Heart Rhythm Center Department Of Cardiovascular Medicine Shiga University Of Medical Science

• Yoshida Michiaki

  Department Of Health Science Shgia University Of Medical Science

• Murakami Yoshitaka

  Department Of Health Science Shiga University Of Medical Science

• Fukuhara Takehisa

  Division Of Cardiology Department Of Medicine Shiga University Of Medical Science

• Kinoshita Masahiko

  First Department Of Internal Medicine

• Okada Mamoru

  First Department Of Internal Medicine Shiga University Of Medical Science

• Fukuhara Takehisa

  First Department of Internal Medicine, Shiga University of Medical Science

• Shichiri Gensho

  First Department of Internal Medicine, Shiga University of Medical Science

• Shichiri Gensho

  First Department Of Internal Medicine Shiga University Of Medical Science

• Murakami Yoshitaka

  Faculty Of Healthcare Kiryu University

• Murakami Yoshitaka

  Fac. Of Healthcare Kiryu Univ.

• Klnoshita Masahiko

  First Department Of Internal Medicine Shiga University Of Medical Science

• Higashikawa Masahito

  Department Of Cardiology Kohoku General Hospital:first Department Of Internal Medicine Shiga Univers

• Nakamura Yasuyuki

  First Department Of Internal Medicine Shiga University Of Medical Science

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