Prognostic Value of Repeated ^<123>I-Metaiodobenzylguanidine Imaging in Patients With Dilated Cardiomyopathy With Congestive Heart Failure Before and After Optimized Treatments-Comparison With Neurohumoral Factors

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概要

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• The present study was undertaken to assess whether repeated measurement of cardiac ^<123>I-Metaiodobenzylguanidine (MIBG) imaging parameters before and after optimized treatments is useful for predicting the prognosis of patients with congestive heart failure (CHF) resulting from dilated cardiomyopathy (DCM). The subjects were 85 consecutive patients with DCM who had a left ventricular ejection fraction (LVEF) of less than 45%. The MIBG and the concentrations of neurohumoral factors were measured at baseline and after 6 months of optimized treatments. Cox proportional hazards analysis was performed to assess the various parameters before and after treatment. Twenty-three patients had a cardiac event (12 died; 11 hospitalized) during a mean follow-up period of 2 years. Although there was no difference between the baseline heart to mediastinum (H/M) ratio measured by MIBG between survivors and nonsurvivors, the HIM ratio was significantly decreased in nonsurvivors after 6 months. Multivariate analysis revealed that a high plasma concentration of brain natriuretic peptide level after 6 months (p=0.0049) and absolute changes in the H/M ratio (p=0.0046) were independent predictors of mortality. Comparison of the H/NI ratio on MIBG imaging before and after optimized additional treatment provided useful information for predicting mortality and was independent of clinical and neurohumoral factors previously shown to be associated with poor prognosis in patients with DCM.

• 社団法人日本循環器学会の論文
• 2002-05-20

著者

• Maeda Keiko

  First Department Of Internal Medicine Shiga University Of Medical Science

• Kinoshita Masahiko

  Division Of Cardiology Department Of Medicine Shiga University Of Medical Science

• MATSUI Toshiki

  First Department of internal Medicine, Shiga University of Medical Science

• Tsutamoto Takayoshi

  First Department of Internal Medicine, Shiga University of Medical Science

• Kusukawa Junya

  First Department of Internal Medicine, Shiga University of Medical Science

• Kinoshita Masashiko

  First Department of Internal Medicine, Shiga University of Medical Science

• Tsutamoto Takayoshi

  Department Of Cardiovascular And Respiratory Medicine Shiga University Of Medical Science

• Kinoshita Masahiko

  Yabase Central Hospital

• Kusukawa Junya

  First Department Of Internal Medicine Shiga University Of Medical Science

• Kinoshita Masahiko

  The First Department Of Internal Medicine Shiga University Of Medical Science

• Kinoshita Masahiko

  First Department Of Internal Medicine Shiga University Of Medical Science

• Mitsunami Kenichi

  Department Of Family Medicine Shiga University Of Medical Science

• Tsutamoto Takayoshi

  First Department Of Internal Medicine Shiga University Of Medical Science

• Matsui Toshiki

  First Department Of Internal Medicine Shiga University Of Medical Science

• Konoshita Masahiko

  First Department Of Internal Medicine Shiga University Of Medical Science

• Mitsunami K

  滋賀医科大学

• Klnoshita Masahiko

  First Department Of Internal Medicine Shiga University Of Medical Science

• Murata Kiyoshi

  Dep. Of Pathology Shiga Univ. Of Medical Sci.

• Mitsunami K

  First Department Of Internal Medicine Shiga University Of Medical Science

• Mitsunami Kenichi

  Dep. Of Radiology Shiga Univ. Of Medical Sci.

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