Assessment of Myocardial Creatine Concentration in Dysfunctional Human Heart by Proton Magnetic Resonance Spectroscopy

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概要

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• Creatine depletion in the non-viable infarcted human heart was previously demonstrated with proton magnetic resonance (MR) spectroscopy (1H MRS). In the present study, we assessed total creatine (CR) in human hearts with non-ischemic dysfunctions such as cardiomyopathy. Using cardiac-gated 1H MRS with MR image-guided PRESS localization, we measured septal CR in healthy and diseased human hearts. Fifteen patients with chronic heart failure (CHF, left ventricular ejection fraction <45%) and 14 age-matched normal subjects were examined. Myocardial CR was significantly (p<0.001) lower in failing hearts (15.1±SD 5.0 μmol/g wet weight, range 8.0-22.9) than in normal hearts (27.6±4.1 μmol/g wet weight, range 20.8-36.2). Myocardial CR concentrations in six heart failure patients with plasma B-type natriuretic peptide (BNP) levels of >200 pg/ml (11.5±0.9 μmol/g wet weight, range 9.9-12.3) were significantly lower than those in four heart failure patients with plasma BNP levels of <200 pg/ml (19.8±2.5 μmol/g wet weight, range 17.7-22.9, p<0.001). Thus, our study showed that myocardial CR was decreased in non-ischemic dysfunctional hearts. Noninvasive measurements of myocardial CR by 1H MRS may be useful in the assessment of the severity of heart failure.

• 日本磁気共鳴医学会の論文
• 2004-04-01

著者

• HORIE Minoru

  Department of Cardiovascular and Respiratory Medicine, Shiga University of Medical Science

• Kimura Takeshi

  神戸市立医療センター中央市民病院 循環器内科

• Matsuo Shinro

  Department of Nuclear Medicine, Kanazawa University Hospital

• Katoh Takao

  日本医科大学 内科学第一講座

• Matsumoto Tetsuya

  Department of Cardiovascular and Respiratory Medicine, Shiga University of Medical Science

• Nakae Ichiro

  Department of Cardiovascular and Respiratory Medicine, Shiga University of Medical Science

• Matsuo Shinro

  滋賀医科大学 内科学第一

• Matsuo Shinro

  滋賀医科大学 呼吸循環器内科

• Matsuo Shinro

  Department Of Cardiovascular And Respiratory Medicine Shiga University Of Medical Science

• Matsuo Shinro

  日本大学 医学部循環器内科部門

• Takenaka Kotoe

  京都大学 院循環器内科

• Tamita Koichi

  先端医療振興財団先端医療センター病院

• Tamita Koichi

  高木循環器科診療所 循環器科

• Tamita Kouichi

  神戸市立中央市民病院

• 三ツ浪 健一

  滋賀医科大学総合診療部

• Kimura Takshi

  京都大学 院放射線学

• MORIKAWA Shigehiro

  Molecular Neuroscience Research Center

• INUBUSHI Toshiro

  Molecular Neuroscience Research Center

• Kinoshita Masahiko

  Division Of Cardiology Department Of Medicine Shiga University Of Medical Science

• Mori H

  Department Of Cardiovascular And Respiratory Medicine Shiga University Of Medical Science

• Morikawa Shigehiro

  Molecular Neuroscience Research Center Shiga University Of Medical Science

• Morikawa Shigehiro

  Molecular Neurobiology Research Center Shiga University Of Medical Science

• Matsumoto Tetsuya

  Department Of Cardiovascular And Respiratory Medicine Shiga University Of Medical Science

• Nakae Ichiro

  Department Of Cardiovascular And Respiratory Medicine Shiga University Of Medical Science

• KOH Terue

  Department of Cardiovascular and Respiratory Medicine, Shiga University of Medical Science

• MITSUNAMI Kenichi

  Department of Family Medicine, Shiga University of Medical Science

• Inubushi Toshiro

  Molecular Neuroscience Research Center Shiga University Of Medical Science

• Inubushi Toshiro

  Molecular Neurobiology Research Center Shiga University Of Medical Science

• Horie Minoru

  Department Of Cardiac Physiology National Cardiovascular Center Research Institute

• Mitsunami Kenichi

  Department Of Family Medicine Shiga University Of Medical Science

• Nakae Ichiro

  Division Of Cardiology Internal Medicine Shiga University Of Medical Science

• Koh Terue

  Department Of Cardiovascular And Respiratory Medicine Shiga University Of Medical Science

• Matsui Toshiki

  First Department Of Internal Medicine Shiga University Of Medical Science

• Konoshita Masahiko

  First Department Of Internal Medicine Shiga University Of Medical Science

• Mitsunami K

  滋賀医科大学

• Murata Kiyoshi

  Dep. Of Pathology Shiga Univ. Of Medical Sci.

• Matsumoto Tetsuya

  Department Of Cardiovascular And Respiratory Medicine

• Mitsunami K

  First Department Of Internal Medicine Shiga University Of Medical Science

• Takahashi Masayuki

  First Department Of Medicine Shiga University Of Medical Science

• Mitsunami Kenichi

  Dep. Of Radiology Shiga Univ. Of Medical Sci.

• Inubushi Toshiro

  Molecular Neuroscience Research Center, Shiga University of Medical Science

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