Gender and Age Effects on Ventricular Repolarization Abnormality in Japanese General Carriers of a G643S Common Single Nucleotide Polymorphism for the KCNQ1 Gene(Clinical Investigation)

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概要

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• Background The KCNQ1 single nucleotide polymorphism (SNP), G643S, is known to be associated with secondary long QT syndrome (LQTS) and to cause a mild reduction in KCNQ1 current. However, the precise incidence and its association with QT intervals remain unknown in the greater cohort of the population in Japan. Methods and Results The genotype was screened at codon 643 of KCNQ1 in 992 residents of a farming community. Eighty-eight individuals (female/male=52/36, 8.9%) were found to have a heterozygous G643S SNP. Matching both gender and age, we randomly selected 243 control (G643G) cases and compared the electrocardiogram parameters in both groups; QT, QTf (QT corrected by Fridericia's formula) intervals, the peak and the end of the T wave (Tpe) interval, and the Tpe/QT ratio. The latter 2 reflect the transmural dispersion of ventricular repolarization (TDR). In G643S carriers, both Tpe and Tpe/QT were significantly longer than in noncarriers, without significant QT prolongation. Both genders showed a tendency for an increase in QTf with aging. In females, both Tpe and Tpe/QT showed a similar significant increase with age, which was not observed in males. Conclusions In elderly females, G643S might be an independent risk factor for secondary LQTS by causing a greater TDR.

• 社団法人日本循環器学会の論文
• 2006-05-20

著者

• HORIE Minoru

  Department of Cardiovascular and Respiratory Medicine, Shiga University of Medical Science

• Ueshima Hirotsugu

  Department of Health Science, Shiga University of Medical Science

• Okamura Tomonori

  Department of Preventive Cardiology, National Cardiovascular center

• Ito Masahiro

  新潟大学 医歯学総合研究科循環器学

• Aiba Takeshi

  Department Of Cardiovascular And Respiratory Medicine Shiga University Of Medical Science

• Ashihara Takashi

  Department Of Cardiovascular And Respiratory Medicine Heart Rhythm Center Shiga University Of Medica

• ITO Makoto

  Department of Cardiovascular Medicine, Shiga University of Medical Science

• KITA Yoshikuni

  Department of Health Science, Shiga University of Medical Science

• TAMAKI Shinji

  Department of Medicine, Kohka Public Hospital

• Ozawa Tomoya

  Department of Cardiology, Toyohashi Heart Center

• Arafune Tatsuhiko

  National Inst. Of Advanced Industrial Sci. And Technol.

• Arafune T

  Graduate School Of Frontier Sciences The University Of Tokyo

• Arafune Tatsuhiko

  Inst. For Human Sci. & Biomed. Eng. National Inst. Of Advanced Industrial Science And Tech.

• Arafune Tatsuhiko

  名古屋大学環境医学研究所

• Takishita Shuichi

  ハートライフ病院 循環器科

• Katanosaka Yuki

  国立循環器病センター

• Yao Takenori

  Department of Cardiovascular and Respiratory Medicine, Shiga University of Medical Science

• Takagi Shuichi

  国立循環器病センター

• Tamaki Shinji

  Division Of Cardiology Department Of Medicine Kohka Public Hospital

• Kita Yoshikuni

  Department Of Health Science Shiga University Of Medical Science

• Yao Takenori

  Department Of Cardiovascular And Respiratory Medicine Shiga University Of Medical Science

• Takishita Shuichi

  Department Of Molecular Cardiology Osaka University Graduate School Of Medicine

• Saruta Takao

  Fukuoka University School Of Medicine

• Ozawa Tomoya

  Department Of Cardiovascular And Respiratory Medicine Shiga University Of Medical Science

• Ozawa Tomoya

  Department Of Cardiology Shiga University Of Medical Science

• Ozawa Tomoya

  Division Of Cardiology Department Of Internal Medicine Shiga University Of Medical Science

• Ito Makoto

  Department Of Cardiovascular And Respiratory Medicine Shiga University Of Medical Science

• Takiuchi Shin

  Division Of Hypertension And Nephrology National Cardiovascular Center

• Ueshima Hirotsugu

  Department Of Health Sceicne Shiga University Of Medical Science

• Takashima Seiji

  Department Of Molecular Cardiology Osaka University Graduate School Of Medicine

• Horie Minoru

  Department Of Cardiac Physiology National Cardiovascular Center Research Institute

• Okamura Tomonori

  Department Of Cardiology National Cardiovascular Center

• Sano Toshio

  2nd Department Of Internal Medicine School Of Medicine Yokohama City University

• Takiuchi Shin

  Department Of Molecular Cardiology Osaka University Graduate School Of Medicine

• Yao Takennori

  Heart Rhytm Center Department Of Cardiovascular Medicine Shiga University Of Medical Science

• Tamaki Shinji

  Department Of Cardiology Shiga University Of Medical Science

• Ito Makoto

  Department Of Bioscience And Biotechnology Graduate School Of Bioresource And Bioenvironmental Scien

• Ito Makoto

  Department Of Cardiovascular Medicine Shiga University Of Medical Science

• Aiba Takeshi

  Department Of Cardiovasculardynamics National Cardiovascular Center

• ITO Makoto

  Department of Bioresources, Faculty of Agriculture, Ehime University

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