Relationship between Metabolic Syndrome and Trp64Arg Polymorphism of the β3-Adrenergic Receptor Gene in a General Sample : The Shigaraki Study

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概要

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• Objective: Simplified sleep polysomnography was performed in 207 adult men to examine the relationship between the frequency of sleep-disordered breathing (SDB) and lifestyle-related illness. Methods: Each subject was checked for SDB using a simplified sleep polysomnograph (Auto-Set Portable; Teijin Limited, Tokyo, Japan). Apnea and hypopnea were detected with a nasal cannula type airflow sensor. Hypoxemia was checked with a percutaneous oxygen saturation (SpO2) monitor. We analyzed the relationships between SDB and body mass index (BMI) and hypertension, hyperlipidemia, liver dysfunction, fatty liver, and abnormal glucose metabolism. Results: Fifty-nine subjects (29%) showed SDB with apnea hypopnea index (AHI) over 15 times/h. The frequency of obesity (BMI≥25), hypertension, hypercholesterolemia, fasting blood glucose level, and HbA1c were significantly higher in patients with SDB than in normal individuals (AHI<5 times/h). The frequencies of hypertension, hyperlipidemia, and abnormal glucose metabolism were compared between the obesity-free normal AHI group and the SDB group, and only that of hypertension was significantly different between the two groups. Conclusions: The present study revealed a high frequency of SDB among Japanese individuals. The results also suggest that as SDB becomes severe, it becomes more closely linked to the onset of lifestyle-related illnesses, such as hypertension, hypercholesterolemia and abnormal glucose metabolism.

• 社団法人　日本内科学会の論文
• 2006-11-01

著者

• HORIE Minoru

  Department of Cardiovascular and Respiratory Medicine, Shiga University of Medical Science

• Ueshima Hirotsugu

  Department of Health Science, Shiga University of Medical Science

• MIKI Tetsuro

  Department of Geriatric Medicine, Ehime University Graduate School of Medicine

• Nakamura Yasuyuki

  Cardiovascular Epidemiology, Kyoto Women’s University

• Okamura Tomonori

  Department of Preventive Cardiology, National Cardiovascular center

• Kadowaki Takashi

  Department of Health Science, Shiga University of Medical Science

• Mochizuki T

  Division Of Anti-aging And Genomics Ehime Proteo-medicine Research Center

• Mochizuki T

  Department Of Radiology Ehime University School Of Medicine Shitsukawa

• Tsujita Yasuyuki

  Department Of Geriatric Medicine Osaka University Graduate School Of Medicine

• Tabara Yasuharu

  国立循環器病センター研究所 疫学部

• Tabara Yasuharu

  自治医科大学 循環器内科

• Ueshima Hirotsugu

  滋賀大学 医学部健康科学科

• Tsubakimoto Yoshinori

  Department Of Cardiolgy Kyoto Prefectural University Of Medicine

• TSUKAMOTO Yusuke

  Syuwa General Hospital

• Tabara Yasuharu

  Department Of Basic Medical Research And Education Ehime University Graduate School Of Medicine

• TAMAKI Shinji

  Division of Cardiology, Department of Medicine, Kohka Public Hospital

• TABARA Yasuharu

  Division of EcoGenetics, Department of Environmental Health and Social Medicine, Ehime University Sc

• KITA Yoshikuni

  Department of Health Science, Shiga University of Medical Science

• Tarutani Yasuhiro

  Division Of Cardiology Department Of Medicine Kohka Public Hospital

• Mochizuki Teruhito

  Department Of Radiology Ehime University School Of Medicine Shitsukawa

• Tamakoshi Akiko

  Department Of Epidemiology National Institute For Longevity Sciences

• Kondo Takaaki

  Department Of Internal Medicine Division Of Cardio-vascular Medicine

• Takishita Shuichi

  ハートライフ病院 循環器科

• Kadowaki Takashi

  滋賀大学 医学部健康科学科

• Katanosaka Yuki

  国立循環器病センター

• Tsujita Yasuyuki

  Department Of Basic Medical Research And Education Ehime University Graduate School Of Medicine

• Kadowaki Takashi

  Department Of Cardiovascular Medicine Graduate School Of Medicine University Of Tokyo

• Takagi Shuichi

  国立循環器病センター

• Tamaki Shinji

  Division Of Cardiology Department Of Medicine Kohka Public Hospital

• Kita Yoshikuni

  Department Of Health Science Shiga University Of Medical Science

• Tomino Yasuhiko

  Department Of Medicine Juntendo University School Of Medicine

• Takishita Shuichi

  Department Of Molecular Cardiology Osaka University Graduate School Of Medicine

• Nishino Y

  Jichi Medical School

• Takagi Kenzo

  Third Division Of The Research Laboratory For Development Of Medicine School Of Pharmacy Hokuriku Un

• Saruta Takao

  Fukuoka University School Of Medicine

• Takiuchi Shin

  Division Of Hypertension And Nephrology National Cardiovascular Center

• Ueshima Hirotsugu

  Department Of Health Sceicne Shiga University Of Medical Science

• Tarutani Yasuhiro

  Department Of Cardiology Kohka Public Hospital

• Takashima Seiji

  Department Of Molecular Cardiology Osaka University Graduate School Of Medicine

• Miki Tetsuro

  Department Of Geriatric Medicine Ehime University Graduate School Of Medicine

• Ueshima Hirotsugu

  京都女子大学 循環器疫学

• Nakamura Yasuyuki

  Department Of Health Science Shiga University Of Medical Science

• Taniyama Yoshihiro

  Division Of Nephrology Sendai Social Insurance Hospital

• Horie Minoru

  Department Of Cardiac Physiology National Cardiovascular Center Research Institute

• Okamura Tomonori

  Department Of Cardiology National Cardiovascular Center

• Nakamura Yosikazu

  Division Of Epidemiology Miyagi Cancer Center Research Institute

• Sano Toshio

  2nd Department Of Internal Medicine School Of Medicine Yokohama City University

• Takiuchi Shin

  Department Of Molecular Cardiology Osaka University Graduate School Of Medicine

• Matayoshi Tetsutaro

  Division Of Hypertension And Nephrology National Cardiovascular Center

• Tamaki Shinji

  Department Of Cardiology Shiga University Of Medical Science

• Yoshida Toshiharu

  Department Of Nephrology Sendai Shakaihoken Hospital

• Tabara Yasuharu

  Division Of Ecogenetics Department Of Environmental Health And Social Medicine Ehime University Scho

• Kondo Takaaki

  Department Of Medical Technology Nagoya University School Of Health Science

• Taguma Yoshio

  Department Of Nephrology Sendai Shakaihoken Hospital

• Tsukamoto Yusuke

  Division Of Nephrology Department Of Internal Medicine Juntendo University School Of Medicine

• Niwa Yoshimitsu

  自治医科大学 公衆衛生学

• TAGUMA Yoshio

  Sendai Shakaihoken Hospital

• Takemura Yukihiro

  Department Of Geriatric Medicine And Nephrology Osaka University Graduate School Of Medicine

• Nakamura Yasuyuki

  Cardiovascular Epidemiology Kyoto Women's University

• Nakamura Yasuyuki

  滋賀医科大学 循環器内科

• Kawamura Takashi

  Department Of Preventive Medicine Nagoya University School Of Medicine

• Miki Tetsuro

  Department Of Diagnostic And Therapeutic Radiology Ehime University Graduate School Of Medicine

• Kadowaki Takashi

  Department Of Cardiology Kawasaki Medical School

• Nakamura Yasuyuki

  Cardiovascular Epidemiology Faculty Of Home Economics Kyoto Women's University

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