Refractory Gradient is Responsible for the Increase in Ventricular Vulnerability Under Sodium Channel Blockade
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概要
- 論文の詳細を見る
Background Previous studies have shown that sodium channel (I_<Na>) blockade increases ventricular vulnerability ; however, there were differences in the degree of the increase. Because the vulnerable window (VW) is altered by the type of preshock refractory gradient (RG), the hypothesis was that the differences in the arrhythmogenesis of I_<Na> blockade result from the different types of preshock RG employed. Methods and Results Simulations of regional electric shock following constant pacing stimuli in 2-dimensional bidomain myocardial sheets under I_<Na> blockade were conducted using 3 types of preshock RG : longitudinally tilted (LRG), transversely tilted (TRG), and non-tilted RG (NRG). The increase in the degree of I_<Na> blockade almost linearly decreased the conduction velocity. The action potential duration in the LRG and TRG cases was non-linearly shortened with the increase in I_<Na> blockade because of electrotonic influences, whereas in the case of NRG it was slightly prolonged. In both LRG and TRG cases, the VW for reentry induction by electric shock was considerably widened by the I_<Na> blockade ; however, this was not the case for NRG in which the VW was rather narrowed by the I_<Na> blockade. Conclusion The type of preshock RG alters the degree of the increase in ventricular vulnerability under I_<Na> blockade.
- 社団法人日本循環器学会の論文
- 2005-02-20
著者
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HORIE Minoru
Department of Cardiovascular and Respiratory Medicine, Shiga University of Medical Science
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Aiba Takeshi
Department Of Cardiovascular And Respiratory Medicine Shiga University Of Medical Science
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Ashihara Takashi
Department Of Cardiovascular And Respiratory Medicine Heart Rhythm Center Shiga University Of Medica
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ITO Makoto
Department of Cardiovascular Medicine, Shiga University of Medical Science
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Nakazawa Kazuo
Laboratory of Development and Evaluation of Biomedical Instruments and Systems, National Cardiovascu
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Arafune Tatsuhiko
National Inst. Of Advanced Industrial Sci. And Technol.
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Arafune T
Graduate School Of Frontier Sciences The University Of Tokyo
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Arafune Tatsuhiko
Inst. For Human Sci. & Biomed. Eng. National Inst. Of Advanced Industrial Science And Tech.
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Nakazawa Kazuo
Department Of Medical Technology Nagoya University School Of Health Sciences
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Yao Takenori
Department of Cardiovascular and Respiratory Medicine, Shiga University of Medical Science
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Yao Takenori
Department Of Cardiovascular And Respiratory Medicine Shiga University Of Medical Science
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Ito Makoto
Department Of Cardiovascular And Respiratory Medicine Shiga University Of Medical Science
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Horie Minoru
Department Of Cardiac Physiology National Cardiovascular Center Research Institute
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Yao Takennori
Heart Rhytm Center Department Of Cardiovascular Medicine Shiga University Of Medical Science
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Mori Hidezo
Department Of Cardiovascular And Respiratory Medicine Shiga University Of Medical Science
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Ito Makoto
Department Of Bioscience And Biotechnology Graduate School Of Bioresource And Bioenvironmental Scien
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Aiba Takeshi
Department Of Cardiovasculardynamics National Cardiovascular Center
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ITO Makoto
Department of Bioresources, Faculty of Agriculture, Ehime University
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