Protective Mechanism of Adenosine to the Rat Arterial Endothelial Dysfunction Induced by Hydrogen Peroxide(Pharmacology)

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概要

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• This study was designed to examine the in vitro effects of adenosine (Ado) on hydrogen peroxide-induced endothelial dysfunction in rats. Endothelial dysfunction was induced by exposing isolated rat mesenteric arteries to hydrogen peroxide (0.5mM) for 12 h using an organ culture system. The protective effects of adenosine were tested by exposing isolated mesenteric arteries to adenosine (3×10^<-7>mol/l, 10^<-6>mol/l, 3×10^<-6>mol/l)+hydrogen peroxide (0.5mM) for 12 h. This exposure to hydrogen peroxide induced a significant concentration-dependent inhibition of endothelium-dependent relaxation (EDR). Coculture of segments of mesenteric artery with adenosine (3×10^<-7>,10^<-6>, and 3×10^<-6>mol/l) attenuated the hydrogen peroxide-induced impairment of vasorelaxation. This impairment was accompanied by a reduction in nitrite/nitrate, nitric oxide (NO) synthase (NOS), superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) activities and an increasing in malondislehyde (MDA) and lactate dehydrogenase (LDH) activities in the aorta. These results indicate that adenosine can be used to attenuate hydrogen peroxide-induced endothelial dysfunction, an effect that may be related to antioxidation, thus enhancing NO production by preventing the decrease in NOS.

• 社団法人日本薬学会の論文
• 2007-07-01

著者

• HORIE Minoru

  Department of Cardiovascular and Respiratory Medicine, Shiga University of Medical Science

• Lu Jun

  Department Of Chemistry University Of Science And Technology Of China

• Lu Jun

  Department Of Pharmacology School Of Medicine Xi'an Jiaotong University

• Wu Jie

  Department of Cardiovascular and Respiratory Medicine, Shiga University of Medical Science

• Horie Minoru

  Department Of Cardiovascular And Respiratory Medicine Shiga University Of Medical Science

• Wu Jie

  Department Of Applied Physics The University Of Tokyo

• Wu Jie

  Department Of Pharmacology School Of Medicine Xi'an Jiaotong University:department Of Cardiovas

• Luo Hong-li

  Department Of Pharmacology School Of Medicine Xi'an Jiaotong University

• Sun Lei

  Department of Pharmacology, School of Life Science and Technology, Xi’an Jiaotong University, China

• Yu Xiao-Jiang

  Department of Pharmacology, School of Life Science and Technology, Xi’an Jiaotong University, China

• Xu Xiao-Li

  Department of Pharmacology, School of Life Science and Technology, Xi’an Jiaotong University, China

• Zang Wei-Jin

  Department of Pharmacology, School of Life Science and Technology, Xi’an Jiaotong University, China

• Zhu Shu-ming

  Department Of Pharmacology School Of Medicine Xi'an Jiaotong University:key Laboratory Of Envir

• WANG Sheng-Peng

  Department of Pharmacology, School of Medicine, Xi'an Jiaotong University

• KONG Shan-Shan

  Department of Pharmacology, School of Medicine, Xi'an Jiaotong University

• Yu Xiao-jiang

  Department Of Pharmacology School Of Medicine Xi'an Jiaotong University

• Zang Wei-jin

  Department Of Pharmacology School Of Medicine Xi'an Jiaotong University:key Laboratory Of Envir

• Xu Xiao-li

  Department Of Pharmacology School Of Medicine Xi'an Jiaotong University

• Horie Minoru

  Department Of Cardiac Physiology National Cardiovascular Center Research Institute

• Lu Jun

  Department Of Aquatic Biosciences Faculty Of Fisheries Tokyo University Of Fisheries

• Sun Lei

  Department Of Chemistry Rutgers The State University Of New Jersey

• Kong Shan-shan

  Department Of Pharmacology School Of Medicine Xi'an Jiaotong University

• Wang Sheng-peng

  Department Of Pharmacology School Of Medicine Xi'an Jiaotong University

• Sun Lei

  Department Of Cardiology Northern People's Hospital Medical College Of Yangzhou University

• Yu Xiao-jiang

  Department Of Pharmacology School Of Life Science And Technology Xi'an Jiaotong University

• Xu Xiao-li

  Department Of Pharmacology School Of Life Science And Technology Xi'an Jiaotong University

• Zang Wei-jin

  Department Of Pharmacology School Of Life Science And Technology Xi'an Jiaotong University

• Sun Lei

  Department Of Pharmacology School Of Life Science And Technology Xi'an Jiaotong University

• Liu Jian-kang

  Institute Of Mitochondrial Biology & Medicine School Of Life Science And Technology Xi'an J

• Liu Jian-kang

  Institute Of Mitochondrial Biology & Medicine School Of Life Science And Technology Xi'an Jiaotong University

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