Increased Uncoupling of β-, β1-and β2-Adrenoceptor to Myocardial Contraction in Failing Human Myocardium : CLINICAL EVALUATION OF CARDIAC PERFORMANCE
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概要
- 論文の詳細を見る
Coupling of myocardial β-, β1-, β2- and α -adrenoceptors (AR) to myocardial contraction was investigated in patients with various degrees of heart failure. With the use of ΔVcfc, a load independent parameter of myocardial contraction, AR mediated contraction was evaluated. β-AR mediated contraction,ΔVcfc by infusion of a β-AR agonist, isoproterenol, declined with the advancement of heart failure from 0.41 Circ/sec (NYHA I) to 0.31 (NYHA II), 0.22 (NYHA III) and 0.12 (NYHA IV). Dobutamine, a β 1-AR full agonist, mediatedΔVcfc was 92-97% of that of isoproterenol. On the other hand, terbutaline sulfate, a full agonist to β2-AR, increasedΔVcfc partially in comparison with isoproterenol; 51% in NYHA I, 52% in NYHA II, 36% in NYHA III and 17% in NYHA IV. An α 1-AR agonist, methoxamine had little effect on myocardial contractility β -AR and α-AR densities were analyzed by saturation binding isotherms of myocardial membrane fraction with ^<125>I-Iodocyanopindolol (ICYP) and ^3H-Bunazosin, respectively. β-1 and β2-ARs were separated by competition binding of ^<125>ICYP with a highly selective β1 AR antagonist, CGP20712A. There was a progressive down regulation of β , β1- and β2-ARs with the advancement of heart failure. A new index was used to examine coupling of ARs to myocardial contracton; Coupling Index. The index was slightly decreased in NYHA II in β - and β1-ARs. In β2-AR, the coupling index declined as heart failure advanced from NYHA I to NYHA IV. These results indicate some mechanism(s) of uncoupling takes place in mild heart failure in β and β1-AR, while in β 2-AR uncoupling progresses from NYHA II to IV. Down regulation of all β -ARs begins from NYHA III on-wards.
- 社団法人日本循環器学会の論文
- 1992-07-20
著者
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Kinoshita Masahiko
Division Of Cardiology Department Of Medicine Shiga University Of Medical Science
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Kinoshita Masahiko
The First Department of Internal Medicine, Shiga University of Medical Science
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Kinoshita Masahiko
Yabase Central Hospital
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Takahashi Masayuki
The First Department of Internal Medicine, Shiga University of Medical Science
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Kinoshita Masahiko
The First Department Of Internal Medicine Shiga University Of Medical Science
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Kinoshita Masahiko
The First Department Of Internal Medicine Shiga Medical College
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Kanamori Toshiyuki
The First Department Of Internal Medicine Shiga University Of Medical Science
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Kinoshita M
First Department Of Internal Medicine Shiga University Of Medical Science
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SHICHIRI GENSHOU
The First Department of Internal Medicine, Shiga University of Medical Science
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AMANO MOTOYA
The First Department of Internal Medicine, Shiga University of Medical Science
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Amano Motoya
The First Department Of Internal Medicine Shiga University Of Medical Science
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Klnoshita Masahiko
First Department Of Internal Medicine Shiga University Of Medical Science
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Shichiri Genshou
The First Department Of Internal Medicine Shiga University Of Medical Science
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Kinoshita M
The First Department Of Internal Medicine Shiga University Of Medical Science
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Kinoshita Masahiko
The 3rd Division Department Of Internal Medicine School Of Medicine Kyoto University
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Kinoshita Masahiko
The First Department Of Internal Medicine
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Takahashi Masayuki
The First Department Of Internal Medicine Shiga University Of Medical Science
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KANAMORI TOSHIYUKI
The First Department of Internal Medicine, Shiga University of Medical Science
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