Determining the Optimum Dose for the Intravenous Administration of Nicardipine in the Treatment of Acute Heart Failure : A Multicenter Study
スポンサーリンク
概要
- 論文の詳細を見る
Nicardipine is a potent arteriolar vasodilator with a negligible negative inotropic effect. Although intravenous administration of this drug has been reported to be effective in the treatment of heart failure, the optimal dose by this route is not clear. This study was designed to determine the optimum dose for the intravenous infusion of nicardipine in the treatment of heart failure. In Trial 1, nicardipine was administered intravenously at a dose of 0.5 μg/kg per min to 14 patients with acute heart failure. The dose was increased to 1.0 μg/kg per min in 13 cases with marked improvement at 2 h. In Trial 2, nicardipine was administered in a double-blind manner to 53 patients at 3 different rates of infusion for 2 h: 1.0 (Group 1, n=19), 2.0 (Group 2, n=15), and 3.0 (Group 3, n=19)μg/kg per min. Neither heart rate nor mean right atrial pressure changed in any of the 3 groups. Favorable hemodynamic effects were evident in all groups beginning 30 min after the start of infusion, with an increase in cardiac index (control vs 2 h after infusion, L/min per m^2)(Group 1: 2.2±0.4 vs 3.1±0.8, Group 2: 2.2±0.4 vs 2.9±0.5, Group 3: 2.3±0.3 vs 3.1±0.7, all p<0.01 compared to the control) and a decrease in diastolic pulmonary artery pressure (Group 1: 26±10 vs 19±7, Group 2: 27± 10 vs 20±8, Group 3: 26±7 vs 18±5 mmHg, all p<0.01). The decrease in systolic pressure was greatest in Group 3 (Group 1: 141±31 vs 119±18, Group 2: 149±25 vs 118±17, Group 3; 147±27 vs 107±14 mmHg, all p<0.01 compared to control, and p<0.05 between Groups 1 and 3). The intravenous drip infusion of nicardipine is effective in the treatment of heart failure by inducing an increase in cardiac output and a decrease in pulmonary artery wedge pressure. The optimal dose in this study was 1.0 μg/kg per min.
- 社団法人日本循環器学会の論文
- 1997-04-20
著者
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OGAWA Hiroshi
Department of Pathology, Seirei Mikatahara General Hospital
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Ogawa Hiroshi
Division Of Cardiology Tokuyama Central Hospital
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KUSUKAWA REIZO
Japanese Circulation Society(JCS)Task Force Committee on Chronic Myocarditis
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Kusukawa Reizo
Department Of Cardiology Tenri Hospital
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Kusukawa Reizo
The Department Of Cardiology Tenri Hospital
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OKUMURA Katsuhiko
Department of Hospital Pharmacy, Kobe University School of Medicine
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Kawamura Keishiro
Department Of Cardiology Sakakibara Heart Institute
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Kawamura Keishiro
The Third Division Department Of Internal Medicine Osaka Medical College
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Kawamura Keishiro
The Third Divisin Department Of Internal Medicine Osaka Medical College
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Kawai Chuichi
The Japan Multicenter Investigation For Cardiovascular Diseases-b (jmic-b) Study Group
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Kawai Chuichi
京都大学 第3内科
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Kawai Chuichi
京都大学 医学研究科循環器内科学
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Hirota Yuzo
The Third Division, Department of Internal Medicine, Osaka Medical College
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KUMADA TOSHIAKI
The Third Division, Department of Internal Medicine, Faculty of Medicine
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Kusukawa R.
Yamaguchi University School Of Medicine
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HORI Ryohei
Department of Pharmacy, Kyoto University Hospital
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Katayama Kazuhiro
Department Of Internal Medicine (iii) Osaka Medical College
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Kawai C
The Japan Multicenter Investigation For Cardiovascular Diseases-b (jmic-b) Study Group
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Kawai Chuichi
The Third Division Department Of Internal Medicine. Faculty Of Medicine Kyoto University
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Kinoshita Masahiko
The First Department of Internal Medicine, Shiga University of Medical Science
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KAWAMURA Keishiro
Kyoto Univ.
-
Kawai Chuichi
The Third Division Department Of Internal Medicine Kyoto University And Department Of Medicine Beth
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Ogawa Hiroshi
Department Of Anatomy And Neurobiology Kyoto Prefectural University Of Medicine
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Kawamura Keishiro
The Third Division Department Of Medicine Osaka Medical College
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Okumura K
Department Of Pharmacy Kobe University School Of Medicine
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Hori R
Kinki Univ. Osaka Jpn
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Hori Ryohei
Department Of Pharmacy Kyoto University Hospital
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Hori Ryohei
Department Of Pharmacy Kyoto University Hospital:product Development Laboratory Sankyo Co. Ltd.
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Kumada Toshiaki
The Third Department Of Internal Medicine Faculty Of Medicine Kyoto University
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Kusukawa R
Department Of Cardiology Tenri Hospital
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the Nicardipine
the Nicardipine Heart Failure Study Group
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Kawai Chuichi
The Third Division Department Of Internal Medicine Faculty Of Medicine Kyoto University
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Kumada Toshiaki
The 3rd Medical Clinic Kyoto University Hospital
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Okumura Katsuhiko
Department Of Clinical Evaluation Of Pharmacotherapy Kobe University Graduate School Of Medicine
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Kinoshita Masahiko
The First Department Of Internal Medicine Shiga University Of Medical Science
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Kinoshita Masahiko
The First Department Of Internal Medicine Shiga Medical College
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Hirota Yuzo
The Third Department Of Internal Medicine Osaka Medical College
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Kusukawa R
The 2nd Departmen Of Internal Medicine Yamaguchi University School Of Medicine
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Kawai Chuichi
The Third Department Of Internal Medicine Faculty Of Medicine Kyoto University
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Kawai C
Third Department Of Internal Medicine Kyoto University Faculty Of Medicine
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Kawai Chuichi
3rd Div. Dept Of Intern Med. Kyoto Univ
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Kaziwara Ko
Department Of Cardiology Tenri Hospital
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Hori Ryohei
Department Of Hospital Pharmacy School Of Medicine Kobe University : Department Of Pharmacy Kyoto Un
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Hirota Yuzo
The Third Division Department Of Medicine Osaka Medical College
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Kusukawa Reizo
The Second Department Of Internal Medicine Yamaguchi University School Of Medicine
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Kumada Toshiaki
The 2nd Department Of Internal Medicine Faculty Of Medicine Yamaguchi University
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Kumada Toshiaki
The Division Of Internal Medicine Yamaguchi University School Of Medicine
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Okumura K
Department Of Hospital Pharmacy School Of Medicine Kobe University
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Ogawa Hiroshi
Division Of Cardiovascular Medicine Department Of Medical Bioregulation Yamaguchi University School
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Kusukawa Reizo
Second Department Of Internal Medicine Yamaguchi University School Of Medicine:national Hamada Hospi
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Hori Ryohei
Kyoto University School Of Medicine Kyoto
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Kusukawa Reizo
Department Of Cardiology Tenri Hospilal
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Okumura Katsuhiko
Department Of Hospital Pharmacy School Of Medicine Kobe University : Department Of Pharmacy Kyoto Un
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Kawai Chuichi
Iii Div. Dept Of Intern. Med. Kyoto Univ.
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Kawai Chuichi
Third Department Of Internal Medicine Kyoto University Faculty Of Medicine
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Kajiwara Ko
3rd Div. Dept Of Intern. Med. And 2nd Div. Dept Of Surg. Kyoto Univ. Faculty Of Med.
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Kusukawa Reizo
Departmet Of Cardiology Tenri Hospital
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Kusukawa Reizo
Tenri Hosp. Div. Of Cardiol. Tenri. Nara Prfe
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Kusukawa Reizo
Central Lab. Kyoto Univ. Hosp.
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Kinoshita Masahiko
The First Department Of Internal Medicine
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Okumura Katsuhiko
Department Of Pharmacy Kyoto University Hospital Faculty Of Medicine Kyoto University
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Okumura Katsuhiko
Department Of Pharmacy Kyoto University Hospital Faculty Of Medicine Kyoto University:(present Addre
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Kawamura Keishiro
The 3rd Division Depertment Of Internal Medicine Osaka Medical College Takatsuki
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Kawamura Keishiro
The Third Department Of Internal Medicine Osaka Medical College
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Katayama Kazuhiro
2nd Dept. Of Internal Med. Yamaguchi University
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Hori Ryohei
Department Of Hospital Pharmacy School Of Medicine Kobe University : Department Of Pharmacy Kyoto Un
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Kawai Chuichi
Division Of Cardiology Takeda General Hospital
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