Role of Hydrogen Peroxide in Cyclosporine-Induced Renal Tubular Cell (LLC-PK1) Injury
スポンサーリンク
概要
- 論文の詳細を見る
We examined the role of hydrogen peroxide production in cyclosporine A (CsA)-induced LLC-PK1 injury. After exposure to CsA (0.1 μM – 100 μM), cytotoxicity assessed by lactate dehydrogenase release to the media increased dose-dependently. LLC-PK1 cells produced hydrogen peroxide, visualized by 2,7-dichlorodihydrofluorescein assay by the treatment with 100 μM CsA, that was blocked by the treatment with catalase. The cytotoxicity of CsA significantly decreased either by the treatment with catalase, mannitol, or deferoxamine, but not with superoxide dismutase. These results suggest the role of hydrogen peroxide as the source of hydroxyl radical, which mainly contributes to CsA-induced LLC-PK1 injury.
- 社団法人 日本薬理学会の論文
- 2003-03-01
著者
-
OGAWA Hiroshi
Department of Pathology, Seirei Mikatahara General Hospital
-
Hamaoka Kenji
Division of Pediatrics, Children's Research Hospital, Kyoto Prefectural University of Medicine
-
Ogawa Hiroshi
Department Of Anatomy And Neurobiology Kyoto Prefectural University Of Medicine
-
Hamaoka Kenji
Division Of Pediatrics Children's Research Hospital Kyoto Prefectural University Of Medicine
-
NISHIDA Masashi
Division of Pediatrics, Children's Research Hospital, Kyoto Prefectural University of Medicine
-
TAMAI Megumi
Department of Pediatrics, Kyoto Prefectural University of Medicine
-
Nishida Masashi
Division Of Pediatrics Children's Research Hospital Kyoto Prefectural University Of Medicine
-
Nishida Masashi
Department Of Applied Chemistry Kumamoto Institute Of Technology
-
Tamai Megumi
Department Of Pediatrics Kyoto Prefectural University Of Medicine
-
Ogawa H
Department Of Pediatrics Kyoto Prefectural University Of Medicine
-
ISHIWARI Kohei
Departments of Pediatrics, Kyoto Prefectural University of Medicine
-
HAMAOKA Kenji
Division of Pediatric Medicine, Children's Research Hospital, Kyoto Prefectural University of Medicine
-
Ishiwari Kohhei
Division of Pediatrics, Children's Research Hospital, Kyoto Prefectural University of Medicine
関連論文
- Linkage of expression of chemokine receptors (CXCR3 and CCR4) and cytotoxic molecules in peripheral T cell lymphoma, not otherwise specified and ALK-negative anaplastic large cell lymphoma
- Evaluation of Left Atrial Function by the Functional Volume Change Curve Derived From Doppler Flow Spectra
- The Response to Drug Therapy in Unstable Angina on the Basis of Coronary Angiography Findings : PATHOGENESIS AND MANAGEMENT OF IMPENDING MYOCARDIAL INFARCTION
- FRS-112 Influence of the Early Ticlopidine Discontinuation on Clinical Outcomes following Sirolimmus-Eluting Stent Implantation(FRS23,Clinical Evidence of DES Era (1) (IHD),Featured Research Session (English),The 73rd Annual Scientific Meeting of The Japa
- 2 Prognostic Factors in Patients with Coronary Artery Disease Treated with Sirolimus-eluting Stent : The HIJ-DES registry(Current Status and Future Perspective of Drug-Eluting Stents,Plenary Session 1 (PL-1) (A),The 73rd Annual Scientific Meeting of The J
- 6 Long-term management of Japanese patients with coronary artery disease in the recent coronary revascularization era for prevention of ACS(Plenary Session 1 (PL1) (IHD) : ACS : Prevention to Treatment)(Special Program)
- 2 Prognostic Factors in Patients with Coronary Artery Disease Treated with Sirolimus-eluting Stent : The HIJ-DES registry(Current Status and Future Perspective of Drug-Eluting Stents,Plenary Session 1 (PL-1) (A),The 73rd Annual Scientific Meeting of The J
- PJ-255 Clinical Background and Consequences of PCI Failure in Patients with Acute Myocardial Infarction : From HIJAMI Registry(PJ043,ACS/AMI (Clinical/Treatment) 2 (IHD),Poster Session (Japanese),The 73rd Annual Scientific Meeting of The Japanese Circulat
- OJ-063 Prognostic Impact of Right Ventricular Infarction in Patients with Acute Myocardial Infarction (AMI) : From the HIJAMI Registry(OJ11,ACS/AMI (Clinical/Diagnosis) (IHD),Oral Presentation (Japanese),The 73rd Annual Scientific Meeting of The Japanese
- PE-048 Insulin Treatments Overweigh the Beneficial Effect of Sirolimus Eluting Stent(PE008,Coronary Revascularization, PCI (DES) 1 (IHD),Poster Session (English),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
- PJ-761 Glycated Hemoglobin and Risk of Cardiovascular Events in Patients without Diabetes in the Heart Institute of Japan Acute Myocardial Infarction(Acute myocardial infarction, clinical(diagnosis / treatment)(12)(IHD),Poster Session(Japanese),The 72nd A
- OJ-022 Percutaneous Coronary Intervention versus Medical Therapy for Stable Effort Angina(Coronary revascularizaion, PCI(06)(IHD),Oral Presentation(Japanese),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
- 6 Prognostic Factors in Patients with Coronary Artery Disease in the Revascularization Era : Challenges of the HIJC Study Group(Symposium 18 (SY-18) (H) How can we Make the Best Use of Japanese Evidences for Future Guidelines,Special Program,The 72nd Annu
- Assignment of the Ground-State Spin-Parity for ^17C through g-Factor Measurement
- Assignment of the Ground-State Spin-Parity for ^C through g-Factor Measurement
- OE-318 Inositol 1,4,5-Trisphosphate 3-Kinase C Polymorphism Associated with Disease Severity and Coronary Artery Lesions in Kawasaki Disease(OE54,Congenital Heart Disease/Kawasaki's Disease (M),Oral Presentation (English),The 73rd Annual Scientific Meetin
- OE-414 How TNFα Receptor Polyorphism Affect the State of Kawasaki Disease?(Congenital heart disease/Kawasaki's disease(01)(M),Oral Presentation(English),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
- Fc Gamma IIIa Receptor 158V/F Polymorphism and Kawasaki Disease(Congenital Heart Disease/Kawasaki's Disease 1 (M), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- Clinical Characteristics and Outcome of Hospitalized Patients With Congestive Heart Failure : Results of the HIJC-HF Registry
- Primary Percutaneous Coronary Intervention vs Conservative Treatment for Acute ST Elevation Myocardial Infarction : Short- and Long-Term Follow-up According to Disease Severity
- P069 RELATION BETWEEN MYOCARDIAL VIABILITY AND CHANGES IN CARDIAC OUTPUT DURING PTCA
- P2-06 GFP imaging analysis of subcellular localization of androgen receptor and estrogen receptor in a single living cell
- Intracellular dynamics of steroid hormone receptor
- A case of occupational contact dermatitis due to 2, 2'-azobis-(2-amidinopropane) dihydrochloride
- STUDY OF THE LEFT VENTRICULAR PERFORMANCE. : EVALUATION OF THE ENDSYSTOLIC PRESSURE-VOLUME LINE OBTAINED BY CHANGING AFTERLOAD : Cardiac Performance : Ist Auditorium : Proceedings of the 43rd Annual Meeting of the Japanese Circulation Society, Tokyo, 1979
- Nonfunctional Paraganglioma of the Pancreas : Report of a Case
- Nuclear Targeting of Akt Enhances Kinase Activity and Survival of Cardiomyocytes
- Role of Hydrogen Peroxide in Cyclosporine-Induced Renal Tubular Cell (LLC-PK1) Injury
- Intima-media thickening of radial artery after transradial intervention (The examination by IVUS)
- Disruption of focal adhesion kinase (FAK) by microelectroporation with FAK-related non-kinase domain induces ballooning of looping heart tube
- Diagnostic Value of SPIO-mediated Breath-hold, Black-blood Fluid-attenuated, Inversion Recovery (BH-BB-FLAIR) Imaging in Patients with Hepatocellular Carcinomas
- Serum Creatinine on Admission Predicts Long-Term Mortality in Acute Myocardial Infarction Patients Undergoing Successful Primary Angioplasty : Data From the Heart Institute of Japan Acute Myocardial Infarction (HIJAMI) Registry
- PE-110 The Elevation of Both Serum Creatinine and CRP Predicts Short- and Long-term Mortality in Patients with ST-elevation Acute Myocardial Infarction(Acute coronary syndrome, basic/clinical-5 (IHD) PE19,Poster Session (English),The 70th Anniversary Annu
- OJ-097 Impact of Percutaneous Coronary Intervention on Short- and long-term Prognosis in High-risk Patients with Myocardial Infarction(Coronary revascularization, PCI-5 (IHD) OJ17,Oral Presentation (Japanese),The 70th Anniversary Annual Scientific Meeting
- Serum Creatinine Predicts the Prognosis of Acute Myocardial Infarction Patients Undergoing Successful Primary Angioplasty : From the HIJAMI Registry(Acute Myocardial Infarction, Clinical (Diagnosis/Treatment) 4 (IHD), The 69th Annual Scientific Meeting of
- Dynamic Determinants of Left Ventricular Early Diastolic Filling in Old Myocardial Infarction : CLINICAL EVALUATION OF CARDIAC PERFORMANCE
- GLOBAL AND REGIONAL DIASTOLIC FILLING DYNAMICS IN COMPENSATED DILATED CARDIOMYOPATHY : The 53th Annual Scientific Session of the Japanese Circulation Society
- PJ-337 Radial artery spasm is an important factor for the radial artery injury after transradial intervention (TRI) : An IVUS study(Peripheral Circulation/Vascular Disease 2(H) : PJ56)(Poster Session (Japanese))
- OJ-110 Chronic Kidney Disease and Long-term Outcomes of Myocardial Infarction(Kidney/Renal circulation(02)(H),Oral Presentation(Japanese),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
- OE-245 The Impact of Chronic Kidney Disease on the Long-term Outcomes of Chronic Coronary Artery Disease(Chronic coronary heart disease/Remodeling(01)(IHD),Oral Presentation(English),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
- Association of Glomerular Filtration Rate With Unsuccessful Primary Percutaneous Coronary Intervention and Subsequent Mortality in Patients With Acute Myocardial Infarction : From the HIJAMI Registry
- Determinant Effecting Intimal Thickening of Radial Artery in Patients with Coronary Artery Disease : An IVUS Study
- Predictors of Intima-Media Thickening in the Radial Artery after Transradial Intervention : An IVUS Study
- Determining the Optimum Dose for the Intravenous Administration of Nicardipine in the Treatment of Acute Heart Failure : A Multicenter Study
- OJ-201 Clinical Implication of Q-Wave Formation in Patients with ST-Segment Elevation Myocardial Infarction(STEMI) in Early-Reperfusion Era(from HIJAMI Registry)(Acute myocardial infarction, clinical (diagnosis / treatment)(04)(IHD),Oral Presentation (Jap
- OE-053 Clinical Characteristics and Prognosis of Acute Myocardial Infarction with Left Main Trunk Insufficiency in Japan : from HIJAMI Registry(Atherosclerosis, clinical(01)(IHD),Oral Presentation(English),The 72nd Annual Scientific Meeting of the Japanes
- FRS-119 Clinical Features and Long-Term Prognosis of Non-ST-segment Elevation Myocardial Infarction (from HIJAMI Registry)(Novel Aspects for Acute Coronary Syndrome(IHD),Featured Research Session,The 72nd Annual Scientific Meeting of the Japanese Circulat
- Structural and Optical Properties of ZnMgO Films Grown by Metal Organic Decomposition
- Strong Room-Temperature UV Luminescence from ZnO Grown by Metal Organic Decomposition
- Recovery from Dry Etching Damage in ZnTe by Thermal Annealing
- Selective Dry Etching of Zinc Telluride Using Aluminum Mask
- Cathodoluminescence Study of Highly Ordered Arrays of InGaAs Quantum Dots
- Effects of Dry Processing on Optical Properties of Zinc Telluride
- Fabrication of ZnTe Nanohole Arrays by Reactive Ion Etching Using Anodic Alumina Templates : Semiconductors
- Growth of AlInN on (111)GaAs Substrates
- Reactive Ion Etching of Indium Nitride Using CH_4 and H_2 Gases
- Low-Temperature Growth of InN Films on (111)GaAs Substrates
- Growth of Tungsten Films on Tool Steel Substrates by rf Magnetron Sputtering
- Crystal Structure and Orientation of Al_xIn_N Epitaxial Layers Grown on (0001) α-Al_2O_3 Substrates
- Growth of Low-Resistivity n-Type ZnTe by Metalorganic Vapor Phase Epitaxy
- Genetic Alterations of Mixed Hyperplastic Adenomatous Polyps in the Colon and Rectum
- -0780-CHARACTERISTICS OF CORONARY HEMODYNAMICS IN CHILDHOOD
- 5 Sex Differences in Long-term Prognosis of Japanese Patients with Acute Myocardial Infarction(New Evidence of Coronary Artery Disease-Pathogenesis, Diagnosis and Therapy, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- Synchrotron-Radiation-Assisted Surface Processes of Diethylzinc on GaAs(100)
- Synchrotron-Radiation-Excited Growth of ZnTe by Alternating Gas Supply Using Metalorganic Sources
- IMPROVEMENT OF REGIONAL WALL MOTION IN MEDICALLY TREATED MYOCARDIAL INFARCTION WITH SINGLIE-VESSEL CORONARY ARTERY DISEASE
- Contrast-enhanced MR Imaging of Metastatic Brain Tumor at 3 Tesla : Utility of T_1-weighted SPACE Compared with 2D Spin Echo and 3D Gradient Echo Sequence
- -1049- USEFULNESS OF SIMULTANEOUS FUNCTION AND PERFUSION IMAGING ON Tc-TETROFOSMIN MYOCARDIAL SCINTIGRAPHY.(PROCEEDINGS OF THE 59th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY)
- PJ-515 Contemporary Practice Use of Sirolimus-eiuting Stents in Dialysis Patients : The Results from HIJC DES Registry(Coronary revascularization, PCI-18 (IHD) PJ87,Poster Session (Japanese),The 70th Anniversary Annual Scientific Meeting of the Japanese C
- Distribution of P300 and SRC-1 in the Rat Brain
- Real-Time Imaging of Corticosteroid Receptor Dynamics in Living Cells with a Green Fluorescent Protein and its Spectral Variants
- The Cyanation of Vinyl Halides with Alkali Cyanides Catalyzed by Nickel(0)-Phosphine Complexes Generated In Situ : Synthetic and Stereochemical Aspects
- Multiple Brain Abscesses in Neonate Caused by Edwardsiella Tarda
- Impact of anticoagulant therapy with dual antiplatelet therapy on prognosis after treatment with drug-eluting coronary stents
- A Rare Case of Serous Cystadenoma of the Pancreas Presenting with Left-Sided Portal Hypertension
- Preparation of Polyoxetane Resins Anchoring Pendant Oligo(oxyethylene) Chains and Uses as Polymer Solvents for Alkali Metal Ions
- Preparation and Characterization of Polyoxetane Resins Anchoring the Pendant Spacer-Separated Hydroxamic Acid Residue
- Side-Chain Liquid-Crystalline Polyoxetanes with a Spacer-Separated Azobenzene Moiety. III.^ Preparation and Characterization of Polyoxetanes Anchoring the Mesogen Cores of a p-Spacer-Substituted Phenyl 4-(4-Alkoxyphenylazo)benzoate in the Side Chain
- Side-Chain Liquid-Crystalline Polyoxetanes with a Spacer-Separated Azobenzene Moiety. II. Preparation and Characterization of Polyoxetanes Derived from 4-(4-Alkoxyphenylazo)phenyl 4-[7-(3-Methyl-3-oxetanyl)-1,6-dioxaheptyl]-benzoates
- THE FALSE POSITIVE EXERCISE TEST : USEFULNESS OF SUBLINGUAL NITROGLYCERIN EXERCISE TEST AND CARDIAC SCINTIGRAPHY FOR DIFFERENTIATING FROM PATIENTS WITH CORONARY ARTERY DISEASE
- -31-THE EFFECT OF SMOKING ON ACUTE MYOCARDIAL INFARCTION
- Enhanced Light Output from ZnTe Light Emitting Diodes by Utilizing Thin Film Structure
- Effect of growth hormone on estrogen receptor binding properties in the chick oviduct in vivo
- Results of patch testing with topical non steroidal anti-inflammatory drugs (NSAIDs) in patients with atopic dermatitis
- Clinical evaluation of hypo-irritant products containing 0.005% nonanoic acid vanillylamide (NVA) on the itching sensation of the patients under dialysis
- Study on the skin function of dialysis patients
- Fabrication of Indium Nitride Nanodots Using Anodic Alumina Templates
- Fabrication of ZnTe Light-Emitting Diodes Using Bridgman-Grown Substrates
- Optical Bandgap Energy of Wurtzite In-Rich AlInN Alloys
- Eight cases of contact dermatitis syndrome
- Identification of cDNA for the HSPA2, HSPA5 and HSPA8 orthologs of the heat shock protein 70 family from guinea fowl (Numida meleagris)
- Absolute Rate Constants of Cr_2(X ^1Σ_g^+) with O_2 NH_3 and C_2H_4 in the Gas Phase at Room Temperature
- A case of contact dermatitis due to Primula obconica
- Neuroendocrine tumor in the breast
- A-39. Radiation Necrosis : Pathological Investigation in 84 Autopsy Cases of Intracranial Tumors
- Amylase Activity in Gallbladder Bile in Patients with Surgical BiliaryTract Disorders: A Preliminary Report from a High Risk Area for BiliaryTract Cancer
- Retrograded Tapioca Starch Prevents Ovarian Hormone Deficiency-Induced Hypercholesterolemia
- Digital Watermarking Technique for Motion Pictures Based on Quantization(Special Section on Cryptography and Information Security)
- Improved Digital Watermark Robustness against Translation and / or Cropping of an Image Area(Special Section on Cryptography and Information Security)
- Changes in Calcium, Magnesium and Phosphorus Contents of Eggshell during Stay in Oviduct Uterus in the Guineafowl and the Chicken