In Vivo ^<31>P Nuclear Magnetic Resonance Spectroscopy in Patients with Old Myocardial Infarction : ADVANCES IN IMAGING TECHNIQUES FOR DIAGNOSIS OF CARDIOVASCULAR DISEASES

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To assess the usefulness of in vivo ^<31>P nuclear magnetic resonance (NMR) spectroscopy, we investigated spectra from the myocardium in 6 patients with old Q-wave infarction (QMI), 6 with old non-Q-wave infarction (NQMI) and 9 con-trols by ECG-gated depth-resolved surface-coil spectroscopy. External hex-amethylphosphoric triamide (HMPT) was used to quantify the signal intensities. Left ventricular weight in the region of interest (LVW) was estimated from IH magnetic resonance images. The extent score by ^<201>T1 scintigraphy was deter-mined in 3 QMI and 4 NQMI patients. No significant differences were found among the 3 groups in peak area ratios of ^<31>P NMR spectra to phosphocreatine (PCr) or adenosine triphosphate (ATP). Compared with controls, significant reductions were observed in values for the peak areas of PCr normalized by the standard HMPT (PCr/HMPT) or by both HMPT and LVW (PCr/HMPT/LVW) for QMI patients (p<0.05), and in ATP/HMPT and ATP/HMPT/LVW for QMI and NQMI patients (p<0.01). There was a significant negative correla-tion between ATP/HMPT and the ^<201>T1 scintigraphy extent score (p<0.05). These findings suggest that in vivo ^<31>P NMR spectroscopy can detect high-energy phosphate reduction in the infarcted myocardium and may be useful in evaluating myocardial viability.
社団法人日本循環器学会の論文
1992-06-20