Myocardial Creatine Concentration in Various Nonischemic Heart Diseases Assessed by ^1H Magnetic Resonance Spectroscopy

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• Background Previous ^<31>P magnetic resonance spectroscopy (MRS) studies demonstrated that the myocardial phosphocreatine-to-ATP ratio offered important information concerning the degree of dysfunction and prognosis in patients with cardiomyopathy. In the present study, we investigated total creatine (CR) levels in various diseased hearts using ^1H MRS. Methods and Results Fourteeen patients with the following conditions were examined: cardiac amyloidosis (n=2); hypertensive heart disease (4); valvular disease (2); hypertrophic cardiomyopathy (2); dilated cardiomyopathy (2); restrictive cardiomyopathy (1); and post-operative atrial septal defect (1). Myocardial CR was measured using ^1H MRS with point-resolved spectroscopy localization. Overall, myocardial CR levels in diseased hearts were significantly lower than those in the control group [16.5±6.0 (n=14) vs 27.1±3.2μmol/g (n=10), p<0.001]. There was a positive correlation between myocardial CR and left ventricular ejection fraction (42.9±13.8%, range 19.5-69.1%) despite the different mechanisms of cardiac dysfunction (r=0.60, p<0.05). Myocardial CR levels in patients who were hospitalized due to heart failure within 1 year were significantly lower than those in other patients [11.3±1.0 (n=4) vs 18.6±5.9μmol/g (n=10), p<0.05]. Conclusions Noninvasive measurement of myocardial CR using ^1H MRS may be valuable in the assessment of disease severity and prediction of clinical course in various forms of heart disease.

• 社団法人日本循環器学会の論文
• 2005-05-20

著者

• TSUTAMOTO Takayoshi

  Department of Cardiovascular and Respiratory Medicine, Shiga University of Medical Science

• HORIE Minoru

  Department of Cardiovascular and Respiratory Medicine, Shiga University of Medical Science

• KOHNO Masakazu

  Kagawa University

• Kimura Takeshi

  神戸市立医療センター中央市民病院 循環器内科

• Matsuo Shinro

  Department of Nuclear Medicine, Kanazawa University Hospital

• 村田 喜代史

  滋賀医科大学 放射線医学講座

• Katoh Takao

  日本医科大学 内科学第一講座

• Nakae Ichiro

  Department of Cardiovascular and Respiratory Medicine, Shiga University of Medical Science

• Nagaoka Iori

  Department Of Cardiovascular And Respiratory Medicine Shiga University Of Medical Science

• Matsuo S

  Department Of Nuclear Medicine Kanazawa University Hospital

• Matsuo Shinro

  滋賀医科大学 内科学第一

• Matsuo Shinro

  滋賀医科大学 呼吸循環器内科

• Matsuo Shinro

  Department Of Cardiovascular And Respiratory Medicine Shiga University Of Medical Science

• Matsuo Shinro

  日本大学 医学部循環器内科部門

• Takenaka Kotoe

  京都大学 院循環器内科

• Tamita Koichi

  先端医療振興財団先端医療センター病院

• Tamita Koichi

  高木循環器科診療所 循環器科

• Tamita Kouichi

  神戸市立中央市民病院

• 三ツ浪 健一

  滋賀医科大学総合診療部

• 三ツ浪 健一

  滋賀医科大医学部附属病院総合診療部

• Kimura Takshi

  京都大学 院放射線学

• MORIKAWA Shigehiro

  Molecular Neuroscience Research Center

• INUBUSHI Toshiro

  Molecular Neuroscience Research Center

• 三ツ浪 健一

  滋賀医科大学 第1内科

• Morikawa Shigehiro

  Molecular Neuroscience Research Center Shiga University Of Medical Science

• Morikawa Shigehiro

  Molecular Neurobiology Research Center Shiga University Of Medical Science

• Nakae Ichiro

  Department Of Cardiovascular And Respiratory Medicine Shiga University Of Medical Science

• KOH Terue

  Department of Cardiovascular and Respiratory Medicine, Shiga University of Medical Science

• MITSUNAMI Kenichi

  Department of Family Medicine, Shiga University of Medical Science

• MITSUNAMI KENICHI

  The First Department of Internal Medicine

• Inubushi Toshiro

  Molecular Neuroscience Research Center Shiga University Of Medical Science

• Inubushi Toshiro

  Molecular Neurobiology Research Center Shiga University Of Medical Science

• Nakae Ichiro

  Department Of Internal Medicine Shiga University Of Medical Science

• Tsutamoto Takayoshi

  Department Of Cardiovascular And Respiratory Medicine

• Horie Minoru

  Department Of Cardiac Physiology National Cardiovascular Center Research Institute

• Mitsunami Kenichi

  Department Of Family Medicine Shiga University Of Medical Science

• Nakae Ichiro

  Division Of Cardiology Internal Medicine Shiga University Of Medical Science

• Koh Terue

  Department Of Cardiovascular And Respiratory Medicine Shiga University Of Medical Science

• Kinoshita Masahiko

  Division Of Cardiology Tenri Hospital

• Konoshita Masahiko

  First Department Of Internal Medicine Shiga University Of Medical Science

• Mitsunami K

  滋賀医科大学

• Murata Kiyoshi

  Dep. Of Pathology Shiga Univ. Of Medical Sci.

• Mitsunami K

  First Department Of Internal Medicine Shiga University Of Medical Science

• Klnoshita Masahiko

  The 1st Department Of Internal Medicine Shiga University Of Medical Science

• Inubushi Toshiro

  Molecular Neuroscience Research Center, Shiga University of Medical Science

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