Serum Level of Uric Acid, Partly Secreted From the Failing Heart, is a Prognostic Marker in Patients With Congestive Heart Failure
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概要
- 論文の詳細を見る
Background A recent study suggested that xanthine oxidase is activated in congestive heart failure (CHF). However, whether uric acid (UA) is secreted from the failing heart remains unknown, so it is currently unclear whether serum UA can provide prognostic information independent of brain natriuretic peptide (BNP). Methods and Results Serum UA was measured in the aortic root (AO) and the coronary sinus (CS) of 74 patients with CHF. The serum UA level was significantly higher in the CS than in the AO. The transcardiac gradient of UA (CS-AO) increased with the severity of CHF, inversely correlated with left ventricular ejection fraction (LVEF) and positively correlated with left ventricular end-diastolic volume index. The plasma levels of norepinephrine, BNP, UA, and LVEF were monitored prospectively in 150 CHF patients for a mean follow-up of 3 years. High plasma levels of UA (p<0.001) and BNP (p<0.001) were shown by multivariate stepwise analysis to be independent predictors of mortality. Conclusions High plasma UA level, partly secreted from the failing heart, is a prognostic predictor independent of BNP in patients with CHF. Monitoring a combination of BNP and UA may be useful for the management of patients with CHF.
- 社団法人日本循環器学会の論文
- 2006-07-20
著者
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TSUTAMOTO Takayoshi
Department of Cardiovascular and Respiratory Medicine, Shiga University of Medical Science
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HORIE Minoru
Department of Cardiovascular and Respiratory Medicine, Shiga University of Medical Science
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SAKAI Hiroshi
Department of Applied Mathematics and Physics, Graduate School of Informatics, Kyoto University
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Sakai Hiroshi
Cardiovascular And Respiratory Medicine Shiga University Of Medical Science
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Tanaka Toshinari
Department Of Cardiovascular And Respiratory Medicine Shiga University Of Medical Science
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Ishikawa Chitose
Department of Cardiovascular and Respiratory Medicine, Shiga University of Medical Science
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Tsutsui Takashi
Department of Cardiovascular Medicine, Shiga University of Medical Science
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Tsutamoto Takayoshi
Department Of Cardiovascular And Respiratory Medicine
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Horie Minoru
Department Of Cardiac Physiology National Cardiovascular Center Research Institute
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Sakai Hiroshi
Department Of Agricultural Chemistry The University Of Tokyo
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