THE EFFECT OF MOLSIDOMINE ON INTRAMYOCARDIAL PRESSURE AND REGIONAL MYOCARDIAL BLOOD FLOW IN THE CANINE ISCHEMIC MYOCARDIUM
スポンサーリンク
概要
- 論文の詳細を見る
Molsidomine was administered intraduodenally to anesthetized dogs which were instrumented for measurements of aortic and left ventricular (LV) pressures, coronary perfusion pressure, intramyocardial pressure in the subendocardium, and subendocardial and subepicardial myocardial blood flow in the ischemic and non-ischemic regions. The dogs were divided into two groups: group M (n=9) was administered molsidomine (0.2 mg/kg), group S (n=10), saline only. Maximum LV systolic pressure decline was 20% in group M and 3% in group S (p<0.05). Maximum LV end-diastolic pressure decline was 63% and 35% in groups M and S, respectively (p<0.05). There was no difference between mean aortic pressure and coronary perfusion pressure between the two groups. The subepicardial blood flow in the ischemic region was decreased (-23% in group M vs 5% in group S; p<0.05), but subendocardial blood flow in the ischemic region increased only slightly in group M. The ratio of subendocardial to subepicardial blood flow increased at 15 and 30 min after administration of molsidomine in the ischemic area (67% in group M vs -10% in group S; p<0.050. but did not show any change in the non-ischemic region. Intramyocardial pressure at systole did not show any change but it decreased at end-diastole, (-32% in group M vs -7% in group S; p<0.05). Thus molsidomine redistributed the myocardial blood flow from the subepicardium to the subendocardium and from the non-ischemic to the ischemic region. This redistribution was associated with a reduction in both LV end-diastolic pressure and intramyocardial pressure at end-diastole.
- 社団法人日本循環器学会の論文
- 1985-05-20
著者
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BITO Keizo
Cardiovascular Division of Shiga Prefectural Medical Center for Adult Diseases
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Kinoshita Masahiko
The First Department of Internal Medicine, Shiga University of Medical Science
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KAWAKITA SEIICHI
The First Department of Internal Medicine, Shiga University of Medical Science
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MITSUNAMI KENICHI
The First Department of Internal Medicine
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MOTOMURA MASAKAZU
The First Department of Internal Medicine, Shiga University of Medical Science
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FUKUHARA TAKEHISA
The First Department of Internal Medicine, Shiga University of Medical Science
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KAWAKITA SEIICHI
Tenri Hospital
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Motomura Masakazu
First Department Of Internal Medicine Shiga University Of Medical Science
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Motomura Masakazu
The First Department Of Intental Medicine Shiga Medical College
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Kinoshita Masahiko
The First Department Of Internal Medicine Shiga Medical College
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Bito Keizo
The First Dept. of Internal Medicine Shiga University of Medical Science
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MASHIRO IWAO
The First Department of internal Medicine, Shiga University of Medical Science
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Kawakita Seiichi
The First Department Of Internal Medicine Shiga University Of Medical Science
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Bito Keizo
First Department Of Internal Medicine Shiga University Of Medical Science
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Bito Keizo
The Third Division Department Of Internal Medicine Faculty Of Medicine Kyoto University
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Furukawa Takami
The First Department Of Internal Medicine Shiga University Of Medical Science
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Fukuhara Takehisa
1st Department Of Medicine Shiga University Of Medical Science
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Fukuhara Takehisa
The First Department Of Internal Medicine Shiga Medical College
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Fukuhara Takehisa
The First Department Of Internal Medicine Shiga University Of Medical Science
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Motomura Masakazu
The First Department Of Internal Medicine Shiga University Of Medical Science
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Mashiro Iwao
Second Okamoto General Hospital
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Mashiro I
Daini Okamoto General Hospital
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Iwao Mashiro
Department Of Medicine Shiga University Of Medical Science And Ohtsu Municipal Hospital
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Kawakita Seiichi
Department Of Cardiology Tenri Hospital
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Bito Keizo
The First Department Of Internal Medicine Shiga University Of Medical Science
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Kawakita S
Shiga Univ. Medical Science
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Klnoshita Masahiko
First Department Of Internal Medicine Shiga University Of Medical Science
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Bito K
滋賀医科大学 第1内科
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Kinoshita Masahiko
The First Department Of Internal Medicine
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Motomura Masakazu
Department Of Medicine Shiga University Of Medical Science And Ohtsu Municipal Hospital
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Bito Keizo
The First Department Of Inteernal Medicine Shiga University Of Medical Science
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Kawakita S
The 1st Department Of Internal Medicine Shiga University Of Medical Science
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