EVALUATION OF 99mTc-ALBUMIN DILUTION CURVE WITH SIMULTANEOUS INJECTION OF 99mTc-AND131I-ALBUMINS

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A critical comparison of radiocardiograms with ^<99m>Tc-and ^<131>I-albumins was made to determine whether or not ^<99m>Tc-albumin can be used as a tracer for measuring blood volume (BV) and cardiac output (CO). Simultaneous injection of both isotopes was given to twenty-two patients to obtain radiocardiograms for each by means of a single scintillation counter with two pulse height analyzers. Such method allows for the determination of the energy levels for both ^<99m>Tc and ^<131>I. The radiocardiographic pattern was somewhat different between ^<99m>Tc-and ^<131>I-radiocardiograms : The ratio of left to right peak height was 16% on the average lower in the ^<99m>Tc-radiocardiogram than in the ^<131>I-one. The reason for the lower ratio is explained by greater absorption of ^<99m>Tc-radioactivity within the soft tissue interposing between the scintillation probe and heart. The values for ^<99m>Tc-derived blood volume were 7.4% on the average larger than those for ^<131>I-derived blood volume (p less than 0.01), although the correlation was excellent (r= 0.98, p less than 0.01). There was no systemic difference between cardiac output determined by ^<99m>Tc- and ^<131>I-albumins since the overestimation of blood volume can compensate for the underestimation of CO/BV by ^<99m>Tc-study. In view of its rapid extravasation, ^<99m>Tc-albumin is not so appropriate tracer for accurate measurements of BV and CO/BV, although it may be used for measurement of cardiac output.
社団法人日本循環器学会の論文
1979-04-20

EVALUATION OF 99mTc-ALBUMIN DILUTION CURVE WITH SIMULTANEOUS INJECTION OF 99mTc-AND131I-ALBUMINS

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