PROTECTION OF CORONARY REPERFUSION INJURY BY A CALCIUM ANTAGONIST

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概要

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• The anterior descending branch of the left coronary artery (LAD) of the dog was ligated for 2 hours and thereafter reperfusion was continued for 1 hour. The regional myocardial blood flow (RMBF) during reperfusion was measured by a radioactive microsphere method. Whether a decrease in RMBF in the reperfused region could be prevented by injection of a calcium antagonist "diltiazem hydrochloride (diltiazem)" to LAD during reperfusion was simultaneously studied. RMBFs in ischemic epicardial (Epi) and endocardial (End) layers and End/Epi ratio 5 minutes after reperfusion were 1.87 ml/min/g, l.75 ml/min/g and 1.06 respectively, showing an increase in all values compared to the values in normal region. RMBFs in the Epi and End and End/Epi ratio 60 minutes after reperfusion were 0.99 ml/min/g, 0.91 ml/min/g and 1.05 respectively, showing a decrease in all values without occurrence of transmural flow gradient. The decrease in RMBFs in the Epi and End 60 minutes after reperfusion could be prevented by diltiazem to show 1.68 ml/min/g and 1.42 ml/min/g respectively which were within normal limits. RMBFs in normal Epi which could be perfused by diltiazem were 1.31 and 1.70 ml/min/g before and after injection of diltiazem while those in normal End before and after injection of the drug were 1.27 and 1.46 ml/min/g respectively; RMBFs in both layers could be increased by diltiazem, with the significant increase in RMBF of normal Epi to show a decrease in the End/Epi ratio after injection of the drug. The conclusions are as follows: (1) Diltiazem increases RMBF in normal myocardium. (2) The gradual decrease in RMBF after reperfusion can be inhibited by the drug so that myocardial injury may be reduced. (3) A possibility exists that clinically the drug is a promising agent for early revascularization.

• 社団法人日本循環器学会の論文
• 1980-07-20

著者

• Kato Shotaro

  The First Department Of Internal Medicine Shiga University Of Medical Science

• Kato Shotaro

  The 1st Department Of Internal Medicine Shiga University Of Medical Science

• Takayama Yukio

  Department Of Internal Medicine Hikone Municipal Hospital

• Miyazaki Mizuo

  Department Of Pharmacology Shiga University Of Medical Sciences

• MOTOMURA MASAKAZU

  The 1st Division of Internal Medicine, Shiga University of Medical Science

• KINOSHITA MASAHIKO

  The 1st Division of Internal Medicine, Shiga University of Medical Science

• Mori Atsumi

  2nd Dept.of Surgerty Shiga University Of Medical Science

• Kawakita Seiichi

  The 1st Department Of Internal Medicine Shiga University Of Medical Science

• SONO Jun

  2nd Dept.of Surgerty,Shiga University of Medical Science

• TAKAYAMA Yuki

  1st Dept.of Internal Mwdicine

• MIYAZAKI MIZUO

  The Department of Pharmacology, Shiga University of Medical Science

• OKUNISHI HIDEKI

  The Department of Pharmacology, Shiga University of Medical Science

• TODA NOBORU

  The Department of Pharmacology, Shiga University of Medical Science

• Mori Atsumi

  The 2nd surgical Division, Kyoto University School of Medicine, Kyoto

• Motomura Masakazu

  First Department Of Internal Medicine Shiga University Of Medical Science

• Kawakita Seiichi

  The First Department Of Internal Medicine Shiga University Of Medical Science

• Motomura Masakazu

  The First Department Of Internal Medicine Shiga University Of Medical Science

• Mashiro Iwao

  Second Okamoto General Hospital

• Mashiro I

  Daini Okamoto General Hospital

• Iwao Mashiro

  Department Of Medicine Shiga University Of Medical Science And Ohtsu Municipal Hospital

• Kawakita Seiichi

  The 1st Department Of Internal Medicine School Of Medicine Shiga University Of Medical Science

• TAKAYAMA YUKIO

  The 1st Division of Internal Medicine, Shiga University of Medical Science

• MASHIRO IWAO

  The 1st Division of Internal Medicine, Shiga University of Medical Science

• MITSUNAMI KENICHI

  The 1st Division of Internal Medicine, Shiga University of Medical Science

• SONO JUN

  The 2nd Division of Surgery, Shiga University of Medical Science

• OKADA YOSHIO

  The 2nd Division of Surgery, Shiga University of Medical Science

• Sono Jun

  2nd Dept.of Surgerty Shiga University Of Medical Science

• Okunishi H

  Shimane Medical Univ. Shimane Jpn

• Okunishi Hideki

  Department Of Pharmacology Shiga University Of Medical Sciences

• Toda Noboru

  Department Of Pharmacology Shiga University Of Medical Sciences

• Okada Yoshio

  2nd Dept.of Surgerty Shiga University Of Medical Science

• Klnoshita Masahiko

  First Department Of Internal Medicine Shiga University Of Medical Science

• Toda Noboru

  The Department Of Pharmacology Shiga University Of Medical Science

• Kinoshita Masahiko

  The 1st Division Of Internal Medicine Shiga University Of Medical Science

• Motomura Masakazu

  Department Of Medicine Shiga University Of Medical Science And Ohtsu Municipal Hospital

• Kawakita S

  The 1st Department Of Internal Medicine Shiga University Of Medical Science

• Kinoshita Masahiko

  The 1st Department Of Internal Medicine Shiga University Of Medical Science

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