BENEFICIAL EFFECT OF DILTIAZEM ON ISCHEMIA-REPERFUSION INJURY IN THE DOG
スポンサーリンク
概要
- 論文の詳細を見る
We determined the effect of the calcium antagonistic agent, diltiazem hydrochloride upon ischemia-reperfusion injury in the dog. Ischemia was produced by occluding the left anterior descending artery for 40 min. Subsequent reperfusion was accomplished for 120 min by virtue of removal of the occlusion. Sixteen of the dogs studied were randomly assigned to diltiazem (D)-treated group (n=8) and saline (S)-treated group (n=8). D in saline was intravenously infused at a concentration of 3 mcq/kg/min starting 15 min after the occlusion. Myocardial blood flow (MBF) was measured using hydrogen gas clearance method. Infarct size was quantified as percent myocardium at risk by triphenyltetrazolium chloride staining. D administration caused a slight decline in mean aortic pressure, heart rate, and heart rate × systolic blood pressure throughout the periods of occlusion and reperfusion. However, there was no significant difference observed in both groups of dogs. MBF to ischemic myocardium was not significantly enhanced by D during ischemia. After 5 min of reperfusion subepicardial MBF was increased in group S, indicating a tendency towards reactive hyperemia. After 120 min of reperfusion there was a significant reduction in subendocardial MBF in group S and the transmural blood flow ratio was 1.230.59 in group D as compared with 0.530.39 in group S (p<0.05). The infarcted area as a percentage of the risk area was considerably smaller in group D than in group S (27.53.0 vs 47.06.5%, p<0.05). D markedly reduced the elevation of tissue calcium especially in the subendocardium. These findings suggest that D reduces the ultimate infarct size through the beneficial effect on ischemia-reperfusion injury.
- 社団法人日本循環器学会の論文
- 1985-02-20
著者
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BITO Keizo
Cardiovascular Division of Shiga Prefectural Medical Center for Adult Diseases
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Kinoshita Masahiko
The First Department of Internal Medicine, Shiga University of Medical Science
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KAWAKITA SEIICHI
The First Department of Internal Medicine, Shiga University of Medical Science
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MITSUNAMI KENICHI
The First Department of Internal Medicine
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FUKUHARA TAKEHISA
The First Department of Internal Medicine, Shiga University of Medical Science
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KAWAKITA SEIICHI
Tenri Hospital
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Kinoshita Masahiko
The First Department Of Internal Medicine Shiga Medical College
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Bito Keizo
The First Dept. of Internal Medicine Shiga University of Medical Science
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MASHIRO IWAO
The First Department of internal Medicine, Shiga University of Medical Science
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KAWAKETA SEIICHI
The First Department of Inteernal Medicine, Shiga University of Medical Science
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Kawakita Seiichi
The First Department Of Internal Medicine Shiga University Of Medical Science
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Bito Keizo
First Department Of Internal Medicine Shiga University Of Medical Science
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Bito Keizo
The Third Division Department Of Internal Medicine Faculty Of Medicine Kyoto University
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Furukawa Takami
The First Department Of Internal Medicine Shiga University Of Medical Science
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Fukuhara Takehisa
1st Department Of Medicine Shiga University Of Medical Science
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Fukuhara Takehisa
The First Department Of Internal Medicine Shiga Medical College
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Fukuhara Takehisa
The First Department Of Internal Medicine Shiga University Of Medical Science
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Mashiro Iwao
Second Okamoto General Hospital
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Mashiro I
Daini Okamoto General Hospital
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Iwao Mashiro
Department Of Medicine Shiga University Of Medical Science And Ohtsu Municipal Hospital
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Kawakita Seiichi
Department Of Cardiology Tenri Hospital
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Bito Keizo
The First Department Of Internal Medicine Shiga University Of Medical Science
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Kawakita S
Shiga Univ. Medical Science
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Klnoshita Masahiko
First Department Of Internal Medicine Shiga University Of Medical Science
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Bito K
滋賀医科大学 第1内科
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Kinoshita Masahiko
The 3rd Division Department Of Internal Medicine School Of Medicine Kyoto University
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Kinoshita Masahiko
The First Department Of Internal Medicine
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Bito Keizo
The First Department Of Inteernal Medicine Shiga University Of Medical Science
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Kawakita S
The 1st Department Of Internal Medicine Shiga University Of Medical Science
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