LONG-TERM EFFECTS OF MOLSIDOMINE ON EXERCISE TOLERANCE IN PATIENTS WITH EXERTIONAL ANGINA PECTORIS

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概要

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• Molsidomine is a derivative of the sydnonimines and is a long-acting vasodilator that may be effective in the treatment of chronic stable angina pectoris. To evaluate the therapeutic efficacy and drug tolerance, eight men with stable angina pectoris performed a symptom-limited maximal exercise test on a computer-assisted treadmill. After ingesting either placebo or molsidomine administered treadmill. After ingesting either placebo or molsidomine administered in single blind fashion 90 min before the exercise test on the first day of treatment, molsidomine decreased the average systolic blood pressure response from 154 ± 3 (SEM) to 135 ± 4 mmHg (p < 0.01). However it did not significantly change the average heart rate response (117 ± 7 to 124 ± 8 beats/min) and the rate-pressure product (18.1 ± 1.2 × 10^3 to 16.8 ± 1.1 × 10^3). The average time up to the onset of ischemia at which significant ST-segment deviation (0.1 mV) first appeared was increased from 9.0 ± 1.7 to 12.8 ± 1.2 min (p < 0.001) after molsidomine. At peak exercise after molsidomine, the mean value of ST-segment deviation in V5 or aVF was decreased (p < 0.001). This result was obtained even though the average exercise duration was increased from 11.4 ± 1.7 to 13.6 ± 1.2 min (p < 0.001). The treadmill score according to Hollenberg was also improved from -47 ± 24 to 1 ± 14 after molsidomine administration. After six weeks of continued therapy with molsidomine the favorable effect on exercise tolerance was significantly decreased in terms of exercise duration, the time up to the onset of ischemia, and the treadmill score. The discontinuation of molsidomine treatment after six months' therapy did not deteriorate the exercise tolerance. Thus, molsidomine is effective in treating stable angina pectoris, but appears to possess a drug tolerance on long-term treatment.

• 社団法人日本循環器学会の論文
• 1983-12-20

著者

• KAWAGUCHI Yoshihiro

  Department of Surgical Oncology, Gifu University

• Takayama Yukio

  Department of Cardiology, Kokura Memorial Hospital

• Kinoshita Masahiko

  The First Department of Internal Medicine, Shiga University of Medical Science

• Takayama Yukio

  Department Of Internal Medicine Hikone Municipal Hospital

• Kawaguchi Yoshihiro

  The St Department Of Internal Medicine Shiga University Of Medical Science

• TAKAYAMA Yuki

  1st Dept.of Internal Mwdicine

• KAWAKITA SEIICHI

  The First Department of Internal Medicine, Shiga University of Medical Science

• SAWAMURA MATSUHIKO

  The First Department of Internal Medicine, Shiga University of Medical Science

• MOTOMURA MASAKAZU

  The First Department of Internal Medicine, Shiga University of Medical Science

• KAWAKITA SEIICHI

  Tenri Hospital

• Motomura Masakazu

  First Department Of Internal Medicine Shiga University Of Medical Science

• Motomura Masakazu

  The First Department Of Intental Medicine Shiga Medical College

• Kinoshita Masahiko

  The First Department Of Internal Medicine Shiga Medical College

• Kawakita Seiichi

  The First Department Of Internal Medicine Shiga University Of Medical Science

• Sawamura Matsuhiko

  The First Department Of Internal Medicine Shiga University Of Medical Science

• Kawaguchi Yoshihiro

  Department Of Electrical Eng. Faculty Of Eng. Kokushikan University

• Motomura Masakazu

  The First Department Of Internal Medicine Shiga University Of Medical Science

• Kawakita Seiichi

  Department Of Cardiology Tenri Hospital

• Kawakita S

  Shiga Univ. Medical Science

• Klnoshita Masahiko

  First Department Of Internal Medicine Shiga University Of Medical Science

• Kinoshita Masahiko

  The 3rd Division Department Of Internal Medicine School Of Medicine Kyoto University

• Kinoshita Masahiko

  The First Department Of Internal Medicine

• Motomura Masakazu

  Department Of Medicine Shiga University Of Medical Science And Ohtsu Municipal Hospital

• Kawakita S

  The 1st Department Of Internal Medicine Shiga University Of Medical Science

• Kawaguchi Yoshihiro

  Department of Applied Chemistry, Faculty of Engineering, Osaka University

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